Enhanced Nanomedicinal Composition for Breast Cancer Treatment
Legal Citation
Summary of the Inventive Concept
An advanced nanomedicinal composition with improved targeting, delivery, and efficacy for breast cancer treatment, overcoming limitations of existing compositions.
Background and Problem Solved
The original patent disclosed a nanomedicinal composition for breast cancer treatment, but it had limitations in terms of targeting, immunogenicity, and sustained release. The new inventive concept addresses these limitations by introducing functionalized porous silicate matrices, hierarchical structures, biocompatible coatings, and sustained release mechanisms.
Detailed Description of the Inventive Concept
The new inventive concept comprises a nanomedicinal composition with a porous silicate matrix functionalized with a targeting moiety, ensuring enhanced delivery to cancer cells. The matrix has a hierarchical structure, increasing its surface area for improved loading capacity. The composition is loaded with a pharmaceutical agent mixture and particles of a magnetic ferrite, and coated with a biocompatible polymer to reduce immunogenicity. The composition is designed to release the pharmaceutical agent mixture in a sustained manner over a period of at least 24 hours. Additionally, the composition can be labeled with a fluorescent marker for real-time tracking of its biodistribution.
Novelty and Inventive Step
The new claims introduce novel features such as functionalized porous silicate matrices, hierarchical structures, biocompatible coatings, and sustained release mechanisms, which are not present in the original patent. These features provide an inventive step by addressing the limitations of the original composition and improving its efficacy and safety.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include different types of targeting moieties, varying hierarchical structures, and diverse biocompatible coatings. Additionally, the composition could be adapted for treating other types of cancer or diseases.
Potential Commercial Applications and Market
The enhanced nanomedicinal composition has significant commercial potential in the breast cancer treatment market, with potential applications in other cancer types and diseases. The market for nanomedicinal compositions is growing, driven by the need for more effective and targeted treatments.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K47/6923 |
| A | A61 | A61K31/138 |
| A | A61 | A61K31/282 |
| A | A61 | A61K33/243 |
| A | A61 | A61K47/10 |
| A | A61 | A61K2121/00 |
| A | A61 | A61K2800/47 |
| B | B82 | B82Y5/00 |
| B | B82 | B82Y25/00 |
| B | B82 | B82Y30/00 |
| B | B82 | B82Y40/00 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Nanomedicine, pharmaceutical composition design, cancer treatment technologies, with expertise in nanocarrier development, drug delivery systems, and targeted therapeutic approaches
Person of Ordinary Skill (PHOSITA) Profile
A researcher with advanced degrees in materials science, chemical engineering, or pharmaceutical sciences, possessing knowledge of nanoparticle synthesis, drug delivery mechanisms, and cancer treatment strategies
Obviousness Rationale
A person having ordinary skill would recognize that the PTD's modifications represent predictable engineering variations to the source patent's nanomedicinal composition. The core technological framework remains consistent, with the PTD introducing incremental improvements in targeting, surface modification, and delivery mechanisms that would be apparent to a skilled practitioner seeking to optimize nanomedicine approaches.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,639 |
|---|---|
| Title | Method for treating breast cancer |
| Assignee(s) | Imam Abdulrahman Bin Faisal University |