Enhanced Nanomedicinal Compositions for Breast Cancer Treatment
Legal Citation
Summary of the Inventive Concept
This inventive concept improves the original nanomedicinal composition for breast cancer treatment by introducing functionalized nanocarriers, sustained release mechanisms, and immunomodulatory agents, enhancing selective uptake, efficacy, and safety.
Background and Problem Solved
The original patent disclosed a nanomedicinal composition for breast cancer treatment, but it had limitations in terms of selective uptake, efficacy, and toxicity. The new inventive concept addresses these limitations by incorporating advanced nanocarrier designs, controlled release mechanisms, and immunomodulatory agents.
Detailed Description of the Inventive Concept
The enhanced nanomedicinal composition comprises a nanocarrier with a porous silicate matrix and particles of a magnetic ferrite, functionalized with a targeting moiety to enhance selective uptake by cancer cells. The nanocarrier is designed to release the pharmaceutical agent mixture in a sustained manner over a prolonged period, ensuring optimal efficacy. Additionally, the composition includes an immunomodulatory agent to enhance the immune response against cancer cells. The system can also be adapted for monitoring the efficacy of the treatment and reducing toxicity in healthy tissues.
Novelty and Inventive Step
The new inventive concept introduces several novel features, including functionalized nanocarriers, sustained release mechanisms, and immunomodulatory agents, which are not present in the original patent. These advancements provide a significant improvement in selective uptake, efficacy, and safety, making the new inventive concept non-obvious and innovative.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept may include varying the type of targeting moiety, adjusting the sustained release profile, or incorporating different immunomodulatory agents. Additionally, the system could be adapted for treating other types of cancer or diseases.
Potential Commercial Applications and Market
The enhanced nanomedicinal composition has significant commercial potential in the breast cancer treatment market, with potential applications in personalized medicine, targeted therapies, and immunotherapy. The market for breast cancer treatment is projected to grow significantly in the coming years, and this inventive concept is well-positioned to capitalize on this trend.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K47/6923 |
| A | A61 | A61K31/138 |
| A | A61 | A61K31/282 |
| A | A61 | A61K33/243 |
| A | A61 | A61K47/10 |
| A | A61 | A61K2121/00 |
| A | A61 | A61K2800/47 |
| B | B82 | B82Y5/00 |
| B | B82 | B82Y25/00 |
| B | B82 | B82Y30/00 |
| B | B82 | B82Y40/00 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Nanomedicine and targeted drug delivery systems for cancer treatment, specifically focusing on nanocarrier design, pharmaceutical compositions, and cancer therapeutic strategies
Person of Ordinary Skill (PHOSITA) Profile
A skilled practitioner with expertise in nanotechnology, pharmaceutical sciences, and oncology, possessing advanced degrees in chemistry, materials science, or biomedical engineering, with knowledge of nanocarrier functionalization, drug delivery mechanisms, and cancer treatment approaches
Obviousness Rationale
A person having ordinary skill in the art would recognize that the PTD's variations represent predictable extensions of the source patent's nanomedicinal composition, utilizing standard techniques in nanocarrier design and cancer treatment to enhance selective targeting, sustained release, and therapeutic efficacy. The proposed modifications align with established strategies in nanomedicine for improving drug delivery and treatment outcomes. These variations would be considered routine optimization and combinatorial approaches well within the capabilities of a skilled practitioner in the field.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,639 |
|---|---|
| Title | Method for treating breast cancer |
| Assignee(s) | Imam Abdulrahman Bin Faisal University |