Adenovirus-based Vaccines and Therapies with Integrated AI, IoT, and Nanomaterials

Publication ID: 24-11857640_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Adenovirus-based Vaccines and Therapies with Integrated AI, IoT, and Nanomaterials,” Published Technical Disclosure No. 24-11857640_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857640_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,640.

Summary of the Inventive Concept

The present inventive concept integrates adenovirus vectors derived from chimpanzee adenovirus with advanced technologies such as AI, IoT, blockchain, and nanomaterials to create a new generation of vaccines and therapies with enhanced efficacy, personalization, and real-time monitoring capabilities.

Background and Problem Solved

Traditional vaccine development has been limited by the lack of effective vectors, inadequate personalization, and insufficient monitoring capabilities. The original patent disclosed adenovirus vectors derived from chimpanzee adenovirus, which have shown promise but still have limitations. The present inventive concept addresses these limitations by combining the adenovirus vectors with advanced technologies to create a more powerful system.

Detailed Description of the Inventive Concept

The inventive concept comprises adenovirus vectors derived from chimpanzee adenovirus, which are integrated with AI-powered genomics analysis tools for identifying optimal vaccine candidates, blockchain-secured genomic data for secure and transparent data management, IoT-enabled lab automation for streamlined vector production, and nanomaterial-based delivery systems for enhanced vaccine efficacy. The system enables real-time monitoring of vaccine efficacy through IoT-enabled sensor networks and provides personalized medicine through AI-driven molecular modeling and machine learning-based prediction of immunogenicity.

Novelty and Inventive Step

The integration of adenovirus vectors with AI, IoT, blockchain, and nanomaterials is novel and non-obvious compared to the original patent, which only disclosed adenovirus vectors. The inventive concept's synergistic combination of these technologies provides a new and innovative solution for vaccine development and therapy.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include the use of different adenovirus vectors, alternative AI algorithms, or various nanomaterials for delivery. Variations may also include the integration of additional technologies such as CRISPR gene editing or synthetic biology.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the vaccine and therapy markets, particularly in the areas of personalized medicine, infectious disease treatment, and cancer therapy. The integration of advanced technologies provides a competitive advantage and enables the development of more effective and targeted treatments.

CPC Classifications

SectionClassGroup
A A61 A61K48/00
C C12 C12N5/0606
C C12 C12N7/00
C C12 C12N15/86
C C12 C12N2710/10021
C C12 C12N2710/10042
C C12 C12N2710/10044
C C12 C12N2800/204

Field of Art

Biotechnology, virology, vaccine development, with expertise in adenoviral vector design, genomic engineering, and immunological technologies

Person of Ordinary Skill (PHOSITA) Profile

A skilled researcher with advanced degrees in molecular biology or bioengineering, familiar with viral vector technologies, genetic modification techniques, and emerging computational approaches in vaccine design

Obviousness Rationale

A person of ordinary skill would recognize that integrating computational technologies with existing adenoviral vector platforms represents a natural progression of vaccine development strategies. The source patent establishes a foundational adenovirus vector technology, which a skilled practitioner would readily see as amenable to enhancement through AI, IoT, and advanced delivery systems. The PTD's proposed variations represent predictable extensions of known vector engineering principles applied to emerging computational and materials technologies.

Obvious Combinations & Variations

Source Patent Element
Adenovirus vector with modified capsid proteins from chimpanzee AdY25
PTD Variation
AI-powered genomics analysis for optimizing vector design and immunogenicity prediction
Obviousness Reasoning
Computational optimization of viral vectors is a known technique, and AI-driven molecular modeling represents a predictable technological enhancement for vector engineering
Source Patent Element
Vaccine vector with modified genomic loci (E1, E3, E4)
PTD Variation
Blockchain-secured genomic data management and IoT-enabled lab automation for vector production
Obviousness Reasoning
Implementing digital infrastructure for biological research is a standard technological progression, representing an obvious method of improving vector development workflows
Source Patent Element
Nucleic acid encapsidation in adenoviral vector
PTD Variation
Nanomaterial-based delivery systems for enhanced vaccine efficacy
Obviousness Reasoning
Advanced drug delivery technologies are well-established in the field, and applying nanomaterial strategies to viral vector vaccines represents a predictable optimization approach
Source Patent Element
Immunogenic compositions of adenoviral vectors
PTD Variation
IoT-enabled sensor networks for real-time vaccine efficacy monitoring
Obviousness Reasoning
Integrating digital monitoring technologies with biological systems is a known technique for improving medical research and treatment tracking
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857640 and the published technical disclosure, a person of ordinary skill in the art would find the proposed variations involving AI, IoT, blockchain, and nanomaterial integration with adenoviral vector technologies to be obvious extensions of existing viral vector engineering principles. The combination of known techniques from computational biology, digital infrastructure, and advanced materials science would be considered a predictable application of existing technological approaches to vaccine vector development.

Original Patent Information

Patent NumberUS 11,857,640
TitleSimian adenovirus and hybrid adenoviral vectors
Assignee(s)OXFORD UNIVERSITY INNOVATION LIMITED