SYNP161 Variants for High-Security and Extreme Environment Applications

Publication ID: 24-11857642_0004_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “SYNP161 Variants for High-Security and Extreme Environment Applications,” Published Technical Disclosure No. 24-11857642_0004_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857642_0004_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,642.

Summary of the Inventive Concept

Adaptation of SYNP161 promoter for gene expression in rod photoreceptors, tailored for high-security bioresearch facilities, disaster relief scenarios, extreme weather conditions, and remote or isolated research environments.

Background and Problem Solved

The original SYNP161 promoter invention provides a nucleic acid sequence for gene expression in rod photoreceptors, but lacks specific adaptations for specialized markets. The new inventive concept addresses the need for secure, reliable, and adaptable gene expression systems in high-security bioresearch facilities, disaster relief scenarios, extreme weather conditions, and remote or isolated research environments.

Detailed Description of the Inventive Concept

The inventive concept involves adapting the SYNP161 promoter for gene expression in rod photoreceptors to specific operational environments. This includes a system for gene expression in high-security bioresearch facilities, a method for expressing genes in disaster relief scenarios, a vector for gene expression in extreme weather conditions, a kit for gene expression in high-security bioresearch facilities, and a method for gene expression in remote or isolated research environments. Each adaptation incorporates the SYNP161 promoter with additional components and modifications to ensure secure, reliable, and adaptable gene expression.

Novelty and Inventive Step

The new claims introduce novel adaptations of the SYNP161 promoter for specific operational environments, providing a non-obvious solution for secure, reliable, and adaptable gene expression in high-security bioresearch facilities, disaster relief scenarios, extreme weather conditions, and remote or isolated research environments.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include adaptations for other specialized markets, such as high-containment laboratories or emergency response situations. Variations could also involve different vector systems, gene editing tools, or expression cassette designs to further enhance the inventive concept's flexibility and applicability.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the biotechnology and pharmaceutical industries, particularly in the development of gene therapies and vaccines for high-security bioresearch facilities, disaster relief scenarios, extreme weather conditions, and remote or isolated research environments.

CPC Classifications

SectionClassGroup
A A61 A61K48/0058
A A61 A61K48/00
C C12 C12N15/63
C C12 C12N15/79
C C12 C12N15/86
C C12 C12N2750/14143
C C12 C12N2830/008

Original Patent Information

Patent NumberUS 11,857,642
TitleSYNP161, a promoter for the expression of genes
Assignee(s)FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH