Enhanced Fluorescence Technology for Diverse Applications
Legal Citation
Summary of the Inventive Concept
This inventive concept leverages the core technology of enhanced fluorescence to create novel systems, methods, and compositions for various industries, including environmental monitoring, food safety, animal health, industrial process control, and bioterrorism detection.
Background and Problem Solved
The original patent addressed the limitations of fluorescent quenching in biomolecule labeling. However, the technology's potential applications were largely confined to the biomedical field. This inventive concept tackles the challenge of adapting the enhanced fluorescence technology to entirely new industries and use cases, overcoming the limitations of traditional fluorescence-based methods in these domains.
Detailed Description of the Inventive Concept
The inventive concept comprises a range of systems, methods, and compositions that utilize the core technology of enhanced fluorescence to improve detection sensitivity and accuracy in diverse applications. For instance, a system for monitoring environmental pollutants employs fluorescently labeled antibodies conjugated with spacer molecules and fluorescent labels to enhance fluorescence signal and reduce quenching. Similarly, a method for detecting foodborne pathogens involves using fluorescently labeled antibodies with enhanced fluorescence properties to detect pathogens in food samples. Other embodiments include devices for diagnosing diseases in animals, compositions for monitoring industrial processes, and methods for detecting bioterrorism agents.
Novelty and Inventive Step
The inventive concept's novelty lies in its application of the enhanced fluorescence technology to novel industries and use cases, which were not anticipated by the original patent. The inventive step resides in the recognition of the technology's potential to address specific challenges in these new domains and the development of tailored solutions to overcome these challenges.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include the use of different types of biomolecules, such as peptides or aptamers, or the incorporation of additional components, such as nanoparticles or graphene, to further enhance fluorescence signals. Variations of the inventive concept could also involve the development of portable or handheld devices for on-site detection and monitoring.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in various industries, including environmental monitoring, food safety, animal health, industrial process control, and bioterrorism detection. The market for these applications is substantial, with growing demands for more sensitive and accurate detection methods. The inventive concept's ability to provide enhanced fluorescence signals and reduce quenching makes it an attractive solution for companies and organizations operating in these industries.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K49/0015 |
| A | A61 | A61K47/10 |
| A | A61 | A61K47/18 |
| A | A61 | A61K49/0058 |
| G | G01 | G01N33/533 |
| G | G01 | G01N33/582 |
| G | G01 | G01N33/68 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biotechnology and analytical chemistry, specifically fluorescence-based detection technologies involving biomolecule labeling and signal enhancement techniques. Practitioners would have advanced degrees in biochemistry, molecular biology, or bioengineering with expertise in fluorescence microscopy, immunoassay development, and biomolecule conjugation methods
Person of Ordinary Skill (PHOSITA) Profile
A skilled practitioner with knowledge of fluorescent labeling techniques, understanding of molecular conjugation chemistry, familiarity with spacer molecule strategies, and experience in developing sensitive detection systems across multiple application domains
Obviousness Rationale
The Published Technical Disclosure (PTD) represents a straightforward extension of the source patent's core fluorescence enhancement technology by applying known conjugation principles to diverse detection contexts. A PHOSITA would recognize that the fundamental molecular engineering approach of using spacer molecules and fluorescent labels can be readily adapted across different detection scenarios without requiring inventive complexity. The PTD's variations demonstrate predictable results by leveraging the established fluorescence enhancement methodology in new application domains.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,643 |
|---|---|
| Title | Compositions and methods for enhanced fluorescence |
| Assignee(s) | Life Technologies Corporation, Pierce Biotechnology, Inc. |