Synergistic Fluorescence Enhancement Systems

Publication ID: 24-11857643_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Fluorescence Enhancement Systems,” Published Technical Disclosure No. 24-11857643_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857643_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,643.

Summary of the Inventive Concept

This inventive concept integrates fluorescent dyes with AI, IoT, blockchain, and new materials to create powerful systems for enhanced fluorescence signals and reduced quenching in biomolecules.

Background and Problem Solved

The original patent, 'Compositions and methods for enhanced fluorescence', addressed the limitations of fluorescently labeled biomolecules in quantitation assays and cellular imaging. However, it did not explore the potential of combining these compositions with emerging technologies to further enhance fluorescence signals and reduce quenching. This inventive concept solves this problem by introducing synergistic combinations of fluorescent dyes with AI, IoT, blockchain, and new materials.

Detailed Description of the Inventive Concept

The inventive concept comprises four main systems: 1) AI-powered optimization of dye-to-protein ratios to reduce quenching; 2) IoT-enabled microscopes for real-time fluorescence imaging and analysis; 3) compositions incorporating nano-particles with metal oxide materials for enhanced fluorescence signals; and 4) microfluidic devices for controlling dye-to-protein ratios and preventing quenching. These systems leverage AI, IoT, blockchain, and new materials to create more powerful and efficient fluorescence enhancement solutions.

Novelty and Inventive Step

The new claims introduce the novel concept of integrating fluorescent dyes with AI, IoT, blockchain, and new materials to create synergistic systems for enhanced fluorescence signals and reduced quenching. This integration is non-obvious and represents a significant departure from the original patent, which focused solely on compositions and methods for enhancing fluorescence.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different AI algorithms, IoT-enabled devices, or blockchain-based data storage systems. Variations could also include the integration of additional technologies, such as robotics or advanced materials, to further enhance fluorescence signals and reduce quenching.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the life sciences and biotechnology industries, where fluorescence-based assays and imaging techniques are widely used. The market for fluorescence-based solutions is expected to grow significantly in the coming years, driven by the increasing demand for advanced diagnostic and research tools.

CPC Classifications

SectionClassGroup
A A61 A61K49/0015
A A61 A61K47/10
A A61 A61K47/18
A A61 A61K49/0058
G G01 G01N33/533
G G01 G01N33/582
G G01 G01N33/68

Original Patent Information

Patent NumberUS 11,857,643
TitleCompositions and methods for enhanced fluorescence
Assignee(s)Life Technologies Corporation, Pierce Biotechnology, Inc.