Intelligent Multi-Signal Fluorescent Probe System for Enhanced Tumor Diagnosis and Treatment

Publication ID: 24-11857644_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Intelligent Multi-Signal Fluorescent Probe System for Enhanced Tumor Diagnosis and Treatment,” Published Technical Disclosure No. 24-11857644_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857644_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,644.

Summary of the Inventive Concept

A novel system integrating a multi-signal fluorescent probe with AI, IoT, blockchain, and nanomaterial technologies for early tumor diagnosis, personalized treatment, and optimized patient data management.

Background and Problem Solved

The original patent disclosed a multi-signal fluorescent probe for early tumor diagnosis, but its limitations included manual data analysis, lack of integration with advanced technologies, and limited scalability. The new inventive concept addresses these limitations by incorporating AI, IoT, blockchain, and nanomaterial technologies to create a more powerful, efficient, and personalized system.

Detailed Description of the Inventive Concept

The system consists of a multi-signal fluorescent probe, an AI module for data analysis and diagnosis, an IoT-enabled biosensor for real-time biomarker detection, a blockchain-based patient data management system for secure and transparent data storage, and a nanomaterial-based delivery system for targeted probe delivery. The AI module analyzes biomarker data and provides a diagnosis report, while the blockchain system ensures secure and transparent patient data management. The IoT-enabled biosensor enables real-time biomarker detection, and the nanomaterial-based delivery system enhances probe delivery efficiency.

Novelty and Inventive Step

The new claims introduce a synergistic combination of distinct technologies, including AI, IoT, blockchain, and nanomaterials, which enables a more powerful, efficient, and personalized system for tumor diagnosis and treatment. The integration of these technologies with the original multi-signal fluorescent probe constitutes a non-obvious improvement over the prior art.

Alternative Embodiments and Variations

Alternative embodiments may include using different AI algorithms, varying the type of nanomaterial used, or integrating additional technologies such as robotics or 3D printing. Variations may include adapting the system for different types of cancer or using the system for other medical applications.

Potential Commercial Applications and Market

The intelligent multi-signal fluorescent probe system has significant commercial potential in the medical diagnostics and treatment industries, particularly in the areas of cancer diagnosis and personalized medicine. The system's ability to provide early diagnosis, personalized treatment, and optimized patient data management makes it an attractive solution for hospitals, research institutions, and pharmaceutical companies.

CPC Classifications

SectionClassGroup
A A61 A61K49/003

Field of Art

Analytical chemistry, biomedical diagnostics, and molecular probe technologies with a focus on fluorescent biomarker detection and medical imaging systems

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degrees in chemistry, biomedical engineering, or related fields, possessing expertise in molecular probe design, fluorescence technologies, and diagnostic system integration

Obviousness Rationale

A PHOSITA would recognize that integrating advanced computational and networking technologies with existing fluorescent probe designs represents a predictable extension of diagnostic technologies. The core fluorescent probe technology from the source patent provides a foundational platform for technological enhancement through AI, IoT, and blockchain systems. These integrations represent logical evolutionary steps in medical diagnostic technologies that would be apparent to a skilled practitioner seeking to improve diagnostic precision and data management.

Obvious Combinations & Variations

Source Patent Element
Multi-signal fluorescent probe for tumor detection
PTD Variation
AI-powered image analysis and diagnostic reporting module integrated with the fluorescent probe
Obviousness Reasoning
Adding computational analysis to diagnostic imaging is a known technique in medical technologies, representing a predictable improvement in diagnostic accuracy and interpretation
Source Patent Element
Chemical synthesis method for fluorescent probe
PTD Variation
Blockchain-secured supply chain and IoT-enabled laboratory equipment for probe preparation
Obviousness Reasoning
Implementing digital tracking and advanced manufacturing technologies in chemical synthesis represents a standard technological progression with finite, identifiable implementation strategies
Source Patent Element
Tumor biomarker detection mechanism
PTD Variation
Nanomaterial-based delivery system for enhanced probe distribution and targeting
Obviousness Reasoning
Enhancing molecular probe delivery through nanomaterials is a well-established approach in targeted diagnostic technologies, representing an obvious optimization strategy
Source Patent Element
Fluorescent probe diagnostic approach
PTD Variation
Personalized treatment recommendation module using machine learning analysis
Obviousness Reasoning
Translating diagnostic data into personalized treatment recommendations is a predictable application of computational technologies in precision medicine
Source Patent Element
Tumor detection methodology
PTD Variation
IoT-enabled real-time biosensor integration for continuous biomarker monitoring
Obviousness Reasoning
Implementing continuous, networked monitoring represents a standard technological evolution in diagnostic systems with clear, foreseeable implementation strategies
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed herein would have been obvious to a person having ordinary skill in the art at the time of invention, as they represent predictable technological integrations building upon the foundational multi-signal fluorescent probe technology disclosed in US Patent 11857644, with no invention beyond the ordinary capabilities of a skilled practitioner in medical diagnostic technologies.

Original Patent Information

Patent NumberUS 11,857,644
TitleMulti-signal fluorescent probe for early diagnosis of tumors, and preparation and use thereof
Assignee(s)Hunan Normal University, Hunan Cancer Hospital