Adaptive Multi-Signal Fluorescent Probes for Niche Applications

Publication ID: 24-11857644_0004_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Adaptive Multi-Signal Fluorescent Probes for Niche Applications,” Published Technical Disclosure No. 24-11857644_0004_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857644_0004_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,644.

Summary of the Inventive Concept

A novel concept for adapting multi-signal fluorescent probes to specific, narrow markets or unique operational environments, enhancing their utility and value in various scenarios.

Background and Problem Solved

The original patent disclosed a multi-signal fluorescent probe for early diagnosis of tumors. However, the probe's design and functionality may not be suitable for extreme weather conditions, high-security needs, disaster relief, or remote, isolated areas. This inventive concept addresses these limitations by introducing specialized variations and niche solutions.

Detailed Description of the Inventive Concept

The new claims introduce four specialized adaptations of the original multi-signal fluorescent probe. The first adaptation enables the probe to operate in high-temperature environments (40°C to 50°C). The second adaptation incorporates a security-enhanced layer to prevent unauthorized access or tampering in high-security facilities. The third adaptation is designed for low-light environments and is powered by a portable, battery-powered device for use in disaster relief scenarios. The fourth adaptation is optimized for operation with limited power resources in remote, isolated areas, featuring automatic power conservation.

Novelty and Inventive Step

The new claims introduce novel and non-obvious adaptations of the original probe, addressing specific challenges in various niche applications. The inventive step lies in the tailored design and functionality of each adaptation, which enables the probes to operate effectively in unique environments.

Alternative Embodiments and Variations

Alternative embodiments may include adapting the probes for use in extreme humidity, high-altitude, or underwater environments. Variations could also involve integrating the probes with wearable devices, robots, or drones for enhanced portability and accessibility.

Potential Commercial Applications and Market

The adaptive multi-signal fluorescent probes have significant commercial potential in various industries, including healthcare, disaster relief, security, and environmental monitoring. Target markets may include hospitals, research institutions, government agencies, and private companies operating in challenging environments.

CPC Classifications

SectionClassGroup
A A61 A61K49/003

Field of Art

Analytical chemistry, specifically fluorescent probes for medical diagnostics, with expertise in molecular design, chemical synthesis, and biomedical sensing technologies

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degree in chemistry or biomedical engineering, experienced in probe design, familiar with fluorescence techniques, chemical modification strategies, and medical diagnostic applications

Obviousness Rationale

A person having ordinary skill would recognize that the source patent's multi-signal fluorescent probe provides a foundational design that can be systematically adapted for various environmental and operational constraints. The PTD's variations represent predictable engineering modifications that extend the probe's utility through standard design optimization techniques. These adaptations demonstrate routine problem-solving within the technical domain of diagnostic probe development.

Obvious Combinations & Variations

Source Patent Element
Multi-signal fluorescent probe with specific molecular structure for tumor diagnosis
PTD Variation
High-temperature adaptation maintaining fluorescent properties between 40-50°C
Obviousness Reasoning
Temperature stability modifications are a known technique in probe design, involving minor molecular adjustments to preserve core functional characteristics
Source Patent Element
Chemical synthesis method involving precise reaction conditions
PTD Variation
Security-enhanced layer preventing unauthorized probe access
Obviousness Reasoning
Adding protective layers is a predictable solution for securing sensitive diagnostic technologies, representing a standard design enhancement
Source Patent Element
Fluorescent probe with signal detection capabilities
PTD Variation
Low-light environment operation using battery-powered portable device
Obviousness Reasoning
Adapting probes for alternative power sources and environmental conditions is a routine engineering optimization within diagnostic technology development
Source Patent Element
Chemical probe with specific molecular configuration
PTD Variation
Power conservation mode for operation in remote areas
Obviousness Reasoning
Implementing automatic power management is a standard design approach for extending device functionality in resource-limited environments
Source Patent Element
Diagnostic probe with specific molecular structure
PTD Variation
User-friendly interface for non-medical personnel
Obviousness Reasoning
Simplifying technical interfaces for broader user accessibility represents a predictable design evolution in medical diagnostic technologies
35 U.S.C. § 103 Summary: Based on US Patent 11857644's foundational multi-signal fluorescent probe design, the present publication demonstrates that the claimed variations represent obvious extensions of the prior art through routine engineering modifications. A person having ordinary skill would recognize these adaptations as predictable solutions arising from standard problem-solving techniques within diagnostic probe technology, thereby rendering subsequent claims obvious under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,644
TitleMulti-signal fluorescent probe for early diagnosis of tumors, and preparation and use thereof
Assignee(s)Hunan Normal University, Hunan Cancer Hospital