Synergistic Multi-Signal Fluorescent Probe System for Enhanced Tumor Diagnosis and Treatment

Publication ID: 24-11857644_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Multi-Signal Fluorescent Probe System for Enhanced Tumor Diagnosis and Treatment,” Published Technical Disclosure No. 24-11857644_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857644_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,644.

Summary of the Inventive Concept

A novel system integrating a multi-signal fluorescent probe with distinct technologies such as AI, IoT, blockchain, and new materials to revolutionize tumor diagnosis and treatment planning.

Background and Problem Solved

The original patent disclosed a multi-signal fluorescent probe for early tumor diagnosis, but its application was limited by the need for manual interpretation and lack of real-time monitoring capabilities. The new inventive concept addresses these limitations by combining the probe with AI-powered image processing, IoT-based sensor networks, blockchain-based secure data sharing, and biocompatible composite materials to create a more powerful, efficient, and accurate system for tumor diagnosis and treatment planning.

Detailed Description of the Inventive Concept

The synergistic system comprises the multi-signal fluorescent probe, an AI-powered image processing module for enhanced diagnostic accuracy, an IoT-based sensor network for real-time monitoring of tumor development, a blockchain-based platform for secure storage and sharing of tumor diagnosis data, and a biocompatible composite material for improved probe stability and biocompatibility. The AI module analyzes probe signals to provide accurate diagnosis, while the IoT sensor network enables real-time monitoring. The blockchain platform ensures secure data sharing, and the composite material enhances probe performance. The system can be integrated with AI-driven treatment planning modules and blockchain-based secure data sharing platforms for personalized tumor treatment planning.

Novelty and Inventive Step

The new claims introduce a synergistic combination of distinct technologies, creating a novel system that is more than the sum of its parts. The integration of AI, IoT, blockchain, and new materials with the multi-signal fluorescent probe provides a non-obvious solution to the limitations of the original patent, offering enhanced diagnostic accuracy, real-time monitoring, and secure data sharing.

Alternative Embodiments and Variations

Alternative embodiments may include integrating the probe with other AI algorithms, using different IoT protocols, or incorporating additional sensors for multi-modal imaging. Variations may include adapting the system for diagnosis and treatment of other diseases or using different biocompatible materials for the composite probe.

Potential Commercial Applications and Market

The synergistic system has significant commercial potential in the medical diagnostics and healthcare industries, particularly in the fields of cancer diagnosis and treatment. The system's enhanced diagnostic accuracy, real-time monitoring capabilities, and secure data sharing features make it an attractive solution for hospitals, research institutions, and pharmaceutical companies.

CPC Classifications

SectionClassGroup
A A61 A61K49/003

Field of Art

Biomedical imaging and diagnostic technologies, specifically fluorescent probes for tumor detection, requiring expertise in analytical chemistry, molecular imaging, and biomedical engineering

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with a PhD or equivalent experience in biomedical engineering, molecular diagnostics, with advanced knowledge of fluorescence techniques, AI image processing, and sensor technologies

Obviousness Rationale

A person of ordinary skill would recognize that integrating the multi-signal fluorescent probe with emerging digital technologies like AI, IoT, and blockchain represents a predictable combination of known techniques to enhance diagnostic capabilities. The source patent's core fluorescent probe technology provides a foundational platform for technological augmentation through standard engineering approaches. These integrations represent incremental improvements using well-established interdisciplinary methodologies in medical diagnostics.

Obvious Combinations & Variations

Source Patent Element
Multi-signal fluorescent probe for tumor detection
PTD Variation
AI-powered image processing module for enhanced diagnostic accuracy
Obviousness Reasoning
Applying machine learning to medical imaging is a known technique, and integrating AI with existing diagnostic tools represents a predictable enhancement of diagnostic capabilities
Source Patent Element
Fluorescent probe with specific molecular targeting
PTD Variation
IoT-based sensor network for real-time tumor development monitoring
Obviousness Reasoning
Extending diagnostic technologies through networked sensor systems is a standard approach in medical monitoring, representing an obvious technological progression
Source Patent Element
Molecular imaging probe with signal detection capabilities
PTD Variation
Blockchain-based secure data storage and sharing platform
Obviousness Reasoning
Implementing secure data management for medical diagnostics is a well-established practice, representing a straightforward technological integration
Source Patent Element
Chemical composition of fluorescent probe
PTD Variation
Biocompatible composite material for improved probe stability
Obviousness Reasoning
Material science optimization through composite design is a routine engineering approach for enhancing probe performance and biocompatibility
Source Patent Element
Tumor diagnostic probe with multi-signal capabilities
PTD Variation
AI-driven personalized treatment planning module
Obviousness Reasoning
Translating diagnostic data into treatment recommendations using computational methods is a predictable extension of existing medical diagnostic technologies
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed herein would have been obvious to a person of ordinary skill in the art at the time of invention, as they represent predictable combinations of known techniques from US Patent 11857644, extending the foundational fluorescent probe technology through standard interdisciplinary engineering methodologies in medical diagnostics.

Original Patent Information

Patent NumberUS 11,857,644
TitleMulti-signal fluorescent probe for early diagnosis of tumors, and preparation and use thereof
Assignee(s)Hunan Normal University, Hunan Cancer Hospital