Multi-signal Fluorescent Probes for Specialized Environments

Publication ID: 24-11857644_0009_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Multi-signal Fluorescent Probes for Specialized Environments,” Published Technical Disclosure No. 24-11857644_0009_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857644_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,644.

Summary of the Inventive Concept

A novel approach to adapt multi-signal fluorescent probes for early tumor diagnosis in high-security, disaster relief, extreme weather, isolated, and high-altitude environments, offering enhanced performance, security, and accessibility.

Background and Problem Solved

The original multi-signal fluorescent probe patent (Chinese Patent Application No. 202210441449.6) has limitations in its applicability to specific, challenging environments. This new inventive concept addresses these limitations by developing specialized variations of the probe for high-security needs, disaster relief, extreme weather conditions, isolated areas, and high-altitude environments.

Detailed Description of the Inventive Concept

The inventive concept comprises a family of multi-signal fluorescent probes and associated systems, tailored to operate effectively in unique operational environments. For high-security environments, a secure data transmission module is integrated to encrypt and transmit diagnostic data. In disaster relief applications, a portable laboratory environment enables on-site preparation of the probe. For extreme weather conditions, the probe is formulated to withstand temperatures ranging from -20°C to 40°C. In isolated areas, a system with a satellite communication module and low-power mode power source enables remote monitoring. In high-altitude environments, a modified structural formula compensates for the effects of low oxygen levels on probe performance.

Novelty and Inventive Step

The new claims introduce novel, non-obvious adaptations of the original multi-signal fluorescent probe, specifically designed to address the challenges of high-security, disaster relief, extreme weather, isolated, and high-altitude environments. These adaptations provide enhanced performance, security, and accessibility, distinguishing them from the original patent.

Alternative Embodiments and Variations

Alternative embodiments may include variations in the probe's structural formula, additional features for enhanced security or portability, and modifications to the associated systems for seamless integration with existing infrastructure. These variations ensure broad conceptual coverage and facilitate adaptation to diverse operational environments.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the fields of medical diagnostics, disaster relief, and environmental monitoring. Target industries include healthcare, biotechnology, and government agencies, with potential applications in remote or challenging environments.

CPC Classifications

SectionClassGroup
A A61 A61K49/003

Field of Art

Analytical chemistry, specifically fluorescent probes for medical diagnostics, with expertise in molecular design, chemical synthesis, and diagnostic imaging techniques

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degree in chemistry or biomedical engineering, experienced in organic synthesis, fluorescence spectroscopy, and medical diagnostic technologies, familiar with adapting molecular probes for specialized environments

Obviousness Rationale

A person of ordinary skill would recognize that the multi-signal fluorescent probe's core structure can be readily adapted to different operational environments by applying standard engineering modifications. The PTD demonstrates predictable variations that extend the source patent's fundamental molecular design through known techniques of environmental adaptation, system integration, and performance optimization.

Obvious Combinations & Variations

Source Patent Element
Multi-signal fluorescent probe with specific structural formula for tumor diagnosis
PTD Variation
Modifying probe structural formula to compensate for high-altitude low oxygen conditions
Obviousness Reasoning
A PHOSITA would recognize that molecular design can be systematically adjusted to maintain probe performance under varying environmental conditions using standard chemical engineering principles
Source Patent Element
Chemical synthesis method involving 2-methoxyphenothiazine and ethyl iodide
PTD Variation
Implementing portable laboratory preparation for disaster relief applications
Obviousness Reasoning
Adapting existing synthesis protocols to mobile environments represents a predictable design choice that a skilled practitioner would find obvious when considering field deployment scenarios
Source Patent Element
Fluorescent probe for diagnostic imaging
PTD Variation
Integrating secure data transmission and satellite communication modules
Obviousness Reasoning
Adding communication and security features to diagnostic technologies is a known technique in medical device development, representing an obvious combination of existing technological capabilities
Source Patent Element
Base molecular probe design for tumor detection
PTD Variation
Formulating probe to withstand extreme temperature ranges from -20°C to 40°C
Obviousness Reasoning
Developing temperature-resistant molecular formulations is a standard engineering approach in diagnostic probe design, representing a predictable optimization strategy
Source Patent Element
Diagnostic probe with fluorescent signaling capabilities
PTD Variation
Creating low-power mode system for remote monitoring in isolated areas
Obviousness Reasoning
Implementing power management strategies for medical diagnostic devices is a routine engineering solution that a skilled practitioner would find obvious when extending technological capabilities
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857644, a person having ordinary skill in the art would find the variations disclosed in this publication obvious, as they represent predictable extensions of the fundamental molecular probe design through standard engineering modifications. The disclosed adaptations demonstrate no inventive step beyond the ordinary capabilities of a skilled practitioner in analytical chemistry and medical diagnostics.

Original Patent Information

Patent NumberUS 11,857,644
TitleMulti-signal fluorescent probe for early diagnosis of tumors, and preparation and use thereof
Assignee(s)Hunan Normal University, Hunan Cancer Hospital