Next-Generation Multi-Signal Fluorescent Probe System for Enhanced Tumor Diagnosis

Publication ID: 24-11857644_0010_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Next-Generation Multi-Signal Fluorescent Probe System for Enhanced Tumor Diagnosis,” Published Technical Disclosure No. 24-11857644_0010_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857644_0010_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,644.

Summary of the Inventive Concept

A revolutionary multi-signal fluorescent probe system that integrates nanoscale sensor arrays, machine learning algorithms, and microfluidic devices for real-time, high-throughput detection of multiple biomarkers, enabling early and accurate tumor diagnosis, treatment monitoring, and personalized medicine.

Background and Problem Solved

The original patent disclosed a multi-signal fluorescent probe for early diagnosis of tumors. However, it has limitations in terms of sensitivity, specificity, and real-time detection capabilities. The next-generation system addresses these limitations by incorporating advanced nanotechnology, artificial intelligence, and microfluidics to provide a more accurate, efficient, and personalized approach to tumor diagnosis and treatment.

Detailed Description of the Inventive Concept

The next-generation multi-signal fluorescent probe system consists of a nanoscale sensor array designed to detect simultaneous changes in multiple biomarkers, enabling early detection of tumor recurrence. The system is integrated with a machine learning algorithm that generates personalized biomarker profiles for patients based on medical history and genetic data. Additionally, the system incorporates a microfluidic device for high-throughput screening of tumor cells, allowing for real-time monitoring of tumor progression and treatment efficacy. The system's advanced capabilities enable clinicians to make data-driven decisions, improving patient outcomes and reducing healthcare costs.

Novelty and Inventive Step

The next-generation system's combination of nanoscale sensor arrays, machine learning algorithms, and microfluidic devices for real-time, high-throughput detection of multiple biomarkers is a novel and non-obvious advancement over the original patent. The system's ability to generate personalized biomarker profiles, monitor tumor progression in real-time, and enable data-driven decision-making represents a significant inventive step in the field of tumor diagnosis and treatment.

Alternative Embodiments and Variations

Alternative embodiments of the next-generation system could include the use of different nanomaterials, sensor configurations, or machine learning algorithms. Variations could also include the integration of additional diagnostic tools, such as imaging modalities or genomic analysis, to provide a more comprehensive understanding of tumor biology and treatment response.

Potential Commercial Applications and Market

The next-generation multi-signal fluorescent probe system has significant commercial potential in the fields of oncology, diagnostics, and personalized medicine. The system could be marketed to hospitals, research institutions, and pharmaceutical companies, with potential applications in clinical trials, companion diagnostics, and precision medicine.

CPC Classifications

SectionClassGroup
A A61 A61K49/003

Original Patent Information

Patent NumberUS 11,857,644
TitleMulti-signal fluorescent probe for early diagnosis of tumors, and preparation and use thereof
Assignee(s)Hunan Normal University, Hunan Cancer Hospital