Near-Infrared Fluorescence-Based Sensing and Monitoring Systems

Publication ID: 24-11857645_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Near-Infrared Fluorescence-Based Sensing and Monitoring Systems,” Published Technical Disclosure No. 24-11857645_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857645_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,645.

Summary of the Inventive Concept

The present inventive concept leverages the core technology of near IR, closed chain, sulfo-cyanine dyes and ligands to create novel sensing and monitoring systems for various industries, including agriculture, environmental monitoring, food safety, and air quality control.

Background and Problem Solved

The original patent focused on compositions for medical imaging, but the core technology has broader applications. The present inventive concept addresses the need for efficient, non-invasive, and accurate sensing and monitoring solutions in various industries, where traditional methods are often limited by cost, complexity, or accuracy.

Detailed Description of the Inventive Concept

The inventive concept involves the use of near IR, closed chain, sulfo-cyanine dyes and ligands to create compositions that bind to specific targets in various industries, emitting fluorescence upon near-infrared radiation excitation. The systems comprise a near-infrared radiation source, a sensor or camera, and the composition. The fluorescence signal is detectable by the sensor or camera, allowing for real-time monitoring and detection of targets. For example, in agriculture, the composition can bind to stressed or diseased crops, enabling early detection and targeted intervention. Similarly, in environmental monitoring, the composition can bind to pollutants, enabling tracking and identification of pollution sources.

Novelty and Inventive Step

The new claims introduce novel applications and use cases for the core technology, including sensing and monitoring systems for agriculture, environmental monitoring, food safety, and air quality control. The inventive step lies in the adaptation of the original technology to these new industries, enabling innovative solutions for pressing problems.

Alternative Embodiments and Variations

Alternative embodiments may include different ligand designs, varying near-infrared radiation sources, or modified sensor architectures. Variations could include handheld devices for point-of-use monitoring or large-scale, networked systems for widespread surveillance.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including agriculture, environmental monitoring, food safety, and air quality control. The market size for these industries is substantial, with growing demand for innovative, efficient, and accurate sensing and monitoring solutions. The inventive concept offers a unique value proposition, enabling early detection, targeted intervention, and improved decision-making.

CPC Classifications

SectionClassGroup
A A61 A61K49/0052
A A61 A61K9/0019
A A61 A61K49/0032
A A61 A61K49/0034
C C09 C09B23/0025
C C09 C09B23/0066
G G01 G01N33/57434

Field of Art

Biomedical imaging and sensing technologies, with expertise in near-infrared fluorescent dye compositions, ligand design, and multi-spectral detection systems across medical, environmental, and diagnostic applications

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with advanced degrees in chemistry, bioengineering, or molecular imaging, possessing knowledge of fluorescent dye chemistry, ligand modification techniques, and cross-domain sensing technology adaptation

Obviousness Rationale

A PHOSITA would recognize that the core near-infrared sulfo-cyanine dye technology from the source patent represents a versatile platform technology with inherent potential for broad sensing applications. The PTD's variations represent predictable extensions of the original technology by applying known fluorescence detection principles to different target domains. The fundamental molecular design and detection mechanism remain substantially unchanged, merely substituting specific ligand targeting elements.

Obvious Combinations & Variations

Source Patent Element
Pharmaceutical composition with near-IR closed chain, sulfo-cyanine dyes and specific ligands
PTD Variation
Agricultural crop health monitoring system using plant-specific ligand modifications
Obviousness Reasoning
Predictable variation involving routine ligand substitution to enable target-specific binding, with established fluorescence detection methodology
Source Patent Element
Near-infrared radiation excitation and fluorescence emission principles
PTD Variation
Environmental monitoring systems for pollution tracking across water, air, and marine contexts
Obviousness Reasoning
Known technique of adapting fluorescent detection to different target environments using substantially identical core technological framework
Source Patent Element
Pharmaceutical dosage form with specific radiation-responsive dye compositions
PTD Variation
Food safety and spoilage detection devices using modified ligand targeting
Obviousness Reasoning
Design choice involving standard molecular engineering principles to extend sensing capabilities to new application domains
Source Patent Element
Sterile container with machine-detectable identifier for medical compositions
PTD Variation
Networked sensing systems with remote detection and identification capabilities
Obviousness Reasoning
Obvious combination of existing detection principles with standard networked sensor architectures
Source Patent Element
Near-infrared radiation-responsive dye composition with specific molecular structure
PTD Variation
Point-of-use handheld monitoring devices across multiple industrial sectors
Obviousness Reasoning
Finite set of predictable technological adaptations using well-established miniaturization and portability engineering techniques
35 U.S.C. § 103 Summary: Based on US Patent 11857645, the present publication demonstrates that the claimed sensing and monitoring systems would have been obvious to a person of ordinary skill in the art at the time of invention, as they represent straightforward technological extensions employing known fluorescence detection principles, routine ligand modifications, and predictable sensor design adaptations across multiple technical domains.

Original Patent Information

Patent NumberUS 11,857,645
TitleCompositions of near IR closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands
Assignee(s)INTUITIVE SURGICAL OPERATIONS, INC.