Near-Infrared Fluorescence-Based Sensing and Monitoring Systems
Legal Citation
Summary of the Inventive Concept
The present inventive concept leverages the core technology of near IR, closed chain, sulfo-cyanine dyes and ligands to create novel sensing and monitoring systems for various industries, including agriculture, environmental monitoring, food safety, and air quality control.
Background and Problem Solved
The original patent focused on compositions for medical imaging, but the core technology has broader applications. The present inventive concept addresses the need for efficient, non-invasive, and accurate sensing and monitoring solutions in various industries, where traditional methods are often limited by cost, complexity, or accuracy.
Detailed Description of the Inventive Concept
The inventive concept involves the use of near IR, closed chain, sulfo-cyanine dyes and ligands to create compositions that bind to specific targets in various industries, emitting fluorescence upon near-infrared radiation excitation. The systems comprise a near-infrared radiation source, a sensor or camera, and the composition. The fluorescence signal is detectable by the sensor or camera, allowing for real-time monitoring and detection of targets. For example, in agriculture, the composition can bind to stressed or diseased crops, enabling early detection and targeted intervention. Similarly, in environmental monitoring, the composition can bind to pollutants, enabling tracking and identification of pollution sources.
Novelty and Inventive Step
The new claims introduce novel applications and use cases for the core technology, including sensing and monitoring systems for agriculture, environmental monitoring, food safety, and air quality control. The inventive step lies in the adaptation of the original technology to these new industries, enabling innovative solutions for pressing problems.
Alternative Embodiments and Variations
Alternative embodiments may include different ligand designs, varying near-infrared radiation sources, or modified sensor architectures. Variations could include handheld devices for point-of-use monitoring or large-scale, networked systems for widespread surveillance.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in various industries, including agriculture, environmental monitoring, food safety, and air quality control. The market size for these industries is substantial, with growing demand for innovative, efficient, and accurate sensing and monitoring solutions. The inventive concept offers a unique value proposition, enabling early detection, targeted intervention, and improved decision-making.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K49/0052 |
| A | A61 | A61K9/0019 |
| A | A61 | A61K49/0032 |
| A | A61 | A61K49/0034 |
| C | C09 | C09B23/0025 |
| C | C09 | C09B23/0066 |
| G | G01 | G01N33/57434 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biomedical imaging and sensing technologies, with expertise in near-infrared fluorescent dye compositions, ligand design, and multi-spectral detection systems across medical, environmental, and diagnostic applications
Person of Ordinary Skill (PHOSITA) Profile
A skilled practitioner with advanced degrees in chemistry, bioengineering, or molecular imaging, possessing knowledge of fluorescent dye chemistry, ligand modification techniques, and cross-domain sensing technology adaptation
Obviousness Rationale
A PHOSITA would recognize that the core near-infrared sulfo-cyanine dye technology from the source patent represents a versatile platform technology with inherent potential for broad sensing applications. The PTD's variations represent predictable extensions of the original technology by applying known fluorescence detection principles to different target domains. The fundamental molecular design and detection mechanism remain substantially unchanged, merely substituting specific ligand targeting elements.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,645 |
|---|---|
| Title | Compositions of near IR closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands |
| Assignee(s) | INTUITIVE SURGICAL OPERATIONS, INC. |