Synergistic Integration of Near IR Closed Chain Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands with Emerging Technologies

Publication ID: 24-11857645_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Integration of Near IR Closed Chain Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands with Emerging Technologies,” Published Technical Disclosure No. 24-11857645_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857645_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,645.

Summary of the Inventive Concept

The inventive concept integrates near IR closed chain sulfo-cyanine dyes and prostate specific membrane antigen ligands with emerging technologies such as AI, IoT, blockchain, and novel materials to create a new, more powerful system for minimally invasive medical procedures, enhancing image analysis, diagnosis, and treatment outcomes.

Background and Problem Solved

The original patent addresses the need for minimally invasive medical techniques to reduce patient recovery time and discomfort. However, the patent's limitations include the lack of integration with emerging technologies, which hinders its potential for enhanced image analysis, diagnosis, and treatment outcomes. The new inventive concept solves this problem by synergistically combining the patented composition with distinct technologies to create a more powerful system.

Detailed Description of the Inventive Concept

The inventive concept comprises a composition of near IR closed chain sulfo-cyanine dyes and prostate specific membrane antigen ligands integrated with AI-powered medical imaging platforms, IoT-enabled sensors, blockchain-based secure data storage systems, and novel material-based delivery systems. The AI-powered platform enhances image analysis and diagnosis, while the IoT-enabled sensors provide real-time monitoring and tracking of the fluorescence signal. The blockchain-based system ensures secure storage and management of patient data, and the novel material-based delivery system enables targeted and controlled release of the composition. This synergistic integration enables a more accurate, efficient, and personalized approach to minimally invasive medical procedures.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious compared to the original patent, as it introduces the integration of emerging technologies to create a more powerful system for minimally invasive medical procedures. The inventive step lies in the unexpected combination of the patented composition with distinct technologies, resulting in a system that is greater than the sum of its parts.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the integration of other emerging technologies, such as machine learning, robotics, or virtual reality, to further enhance the system's capabilities. Variations of the composition and delivery system could also be explored to optimize the system's performance and versatility.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the medical device and pharmaceutical industries, particularly in the areas of minimally invasive surgery, medical imaging, and personalized medicine. The target market includes hospitals, clinics, and medical research institutions, with potential for widespread adoption and significant revenue growth.

CPC Classifications

SectionClassGroup
A A61 A61K49/0052
A A61 A61K9/0019
A A61 A61K49/0032
A A61 A61K49/0034
C C09 C09B23/0025
C C09 C09B23/0066
G G01 G01N33/57434

Field of Art

Biomedical imaging and pharmaceutical compositions, specifically near-infrared fluorescent dye systems for medical diagnostics and minimally invasive procedures, requiring advanced knowledge in organic chemistry, medical imaging technologies, and pharmaceutical formulation

Person of Ordinary Skill (PHOSITA) Profile

A researcher with a PhD in biomedical engineering, chemistry, or related field, experienced in medical imaging technologies, fluorescent dye design, and emerging medical diagnostic platforms, with working knowledge of AI, IoT, and advanced material delivery systems

Obviousness Rationale

A PHOSITA would recognize that integrating emerging digital technologies with existing near-infrared fluorescent dye compositions represents a predictable extension of known medical imaging techniques. The combination of AI-powered image analysis, IoT sensor tracking, and blockchain data management with established sulfo-cyanine dye formulations would be an obvious optimization strategy for enhancing diagnostic and surgical procedures. The technical elements in the published technical disclosure represent incremental improvements using standard technological integration approaches.

Obvious Combinations & Variations

Source Patent Element
Pharmaceutical composition with near IR closed chain sulfo-cyanine dyes for medical imaging
PTD Variation
Integration of AI-powered medical imaging platform for enhanced image analysis and diagnosis
Obviousness Reasoning
Applying machine learning to medical imaging is a known technique, and a PHOSITA would find it obvious to enhance existing imaging technologies with AI-driven analysis for improved diagnostic capabilities
Source Patent Element
Sterile, non-toxic pharmaceutical composition for patient administration
PTD Variation
IoT-enabled sensors for real-time fluorescence signal monitoring and tracking
Obviousness Reasoning
Real-time medical monitoring using sensor technologies is a predictable technological progression, representing a design choice for improving diagnostic information capture
Source Patent Element
Dosage forms suitable for medical procedures
PTD Variation
Blockchain-based secure data storage system for patient data management
Obviousness Reasoning
Implementing secure digital record management is an obvious solution for addressing data privacy and tracking concerns in medical technologies
Source Patent Element
Pharmaceutical composition with specific molecular structure
PTD Variation
Nanomaterial-based targeted and controlled release delivery system
Obviousness Reasoning
Advanced drug delivery systems using nanomaterials represent a known approach for improving pharmaceutical composition performance and targeting
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed in the published technical disclosure would have been obvious to a person having ordinary skill in the art at the time of invention, as the combination of the near-infrared sulfo-cyanine dye composition from US Patent 11857645 with emerging digital technologies represents a predictable and incremental improvement in medical imaging and diagnostic methodologies.

Original Patent Information

Patent NumberUS 11,857,645
TitleCompositions of near IR closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands
Assignee(s)INTUITIVE SURGICAL OPERATIONS, INC.