Environmental and Agricultural Monitoring using Near IR, Closed Chain, Sulfo-Cyanine Dyes

Publication ID: 24-11857645_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Environmental and Agricultural Monitoring using Near IR, Closed Chain, Sulfo-Cyanine Dyes,” Published Technical Disclosure No. 24-11857645_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857645_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,645.

Summary of the Inventive Concept

This inventive concept applies the core technology of near IR, closed chain, sulfo-cyanine dyes to novel applications in environmental monitoring, agricultural pest tracking, food spoilage detection, and medical instrument contamination detection.

Background and Problem Solved

The original patent focused on minimally invasive medical techniques, but the core technology of near IR, closed chain, sulfo-cyanine dyes has broader potential. Current environmental and agricultural monitoring methods often rely on expensive, time-consuming, or inaccurate techniques. This inventive concept addresses these limitations by leveraging the dyes' fluorescence properties to detect pollutants, pests, spoilage, and contamination.

Detailed Description of the Inventive Concept

The new inventive concept combines near IR, closed chain, sulfo-cyanine dyes with pollutant-specific, pest-specific, spoilage-specific, or bacteria-specific ligands to create novel systems and methods for monitoring environmental pollutants, detecting heavy metals in water, tracking agricultural pests, monitoring food spoilage, and detecting bacterial contamination in medical instruments. These systems and methods utilize the dyes' fluorescence signals in response to binding with the target molecule, enabling rapid, accurate, and cost-effective detection.

Novelty and Inventive Step

The new claims introduce entirely new applications and use cases for the near IR, closed chain, sulfo-cyanine dyes, departing from the original patent's medical focus. The inventive step lies in recognizing the potential of these dyes to address pressing environmental and agricultural challenges, and in developing novel systems and methods that capitalize on this potential.

Alternative Embodiments and Variations

Alternative embodiments could include using different types of ligands, modifying the dye structure for improved sensitivity or specificity, or integrating the detection systems with existing monitoring infrastructure. Variations could also involve adapting the technology for use in other industries, such as industrial process monitoring or consumer product safety testing.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential in the environmental monitoring, agricultural, food safety, and medical instrument industries. The market for such solutions is substantial, with growing demand for accurate, efficient, and cost-effective monitoring and detection technologies.

CPC Classifications

SectionClassGroup
A A61 A61K49/0052
A A61 A61K9/0019
A A61 A61K49/0032
A A61 A61K49/0034
C C09 C09B23/0025
C C09 C09B23/0066
G G01 G01N33/57434

Field of Art

Biomedical and chemical engineering, with expertise in fluorescent molecular diagnostics, dye chemistry, and analytical detection systems across medical, environmental, and agricultural applications

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degree in chemistry, biochemistry, or bioengineering, possessing knowledge of molecular tagging techniques, fluorescence spectroscopy, and ligand-based detection methodologies

Obviousness Rationale

A PHOSITA would recognize that the near IR, closed chain, sulfo-cyanine dyes disclosed in the source patent represent a versatile molecular platform with inherent signal transduction capabilities that could be readily adapted to alternative detection contexts. The fundamental mechanism of fluorescence signaling through molecular binding is a well-established technique that can be predictably extended across different target domains. The PTD's variations represent a straightforward application of known molecular engineering principles to expand the dye technology's utility beyond its original medical diagnostic context.

Obvious Combinations & Variations

Source Patent Element
Near IR, closed chain, sulfo-cyanine dyes with specific molecular binding capabilities
PTD Variation
Applying the dye system to environmental pollutant detection using pollutant-specific ligands
Obviousness Reasoning
Substituting medical diagnostic ligands with environmental detection ligands represents a predictable variation using known molecular engineering techniques
Source Patent Element
Pharmaceutical composition with unit dosage delivery mechanisms
PTD Variation
Developing detection systems with quantifiable fluorescence signal measurement protocols
Obviousness Reasoning
Adapting dosage measurement principles to signal quantification is a routine design modification for a skilled practitioner
Source Patent Element
Molecular targeting using specific ligand binding mechanisms
PTD Variation
Extending ligand specificity to agricultural pest, food spoilage, and bacterial contamination detection
Obviousness Reasoning
Selecting appropriate ligands for different target molecules is a standard technique in molecular detection technologies
Source Patent Element
Fluorescence-based molecular detection methodology
PTD Variation
Implementing near IR dye systems across diverse monitoring and detection applications
Obviousness Reasoning
Translating a core detection technology across different technical domains represents an obvious technological extension
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857645, a person having ordinary skill in the art would find the environmental and agricultural monitoring techniques disclosed herein to be obvious variations of the existing near IR, closed chain, sulfo-cyanine dye technology. The fundamental molecular detection principles remain consistent, with only routine modifications required to adapt the core technology to alternative detection contexts.

Original Patent Information

Patent NumberUS 11,857,645
TitleCompositions of near IR closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands
Assignee(s)INTUITIVE SURGICAL OPERATIONS, INC.