Synergistic Integration of Near IR, Closed Chain, Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands with Emerging Technologies

Publication ID: 24-11857645_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Integration of Near IR, Closed Chain, Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands with Emerging Technologies,” Published Technical Disclosure No. 24-11857645_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857645_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,645.

Summary of the Inventive Concept

The present inventive concept integrates near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands with emerging technologies such as AI, IoT, blockchain, and microfluidics to create a novel system for visualizing, detecting, and treating prostate cancer, enabling real-time image analysis, personalized medicine, and targeted therapy.

Background and Problem Solved

The original patent disclosed compositions of near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands for minimally invasive medical techniques. However, the patent's limitations included the lack of integration with emerging technologies, which limited its potential for real-time image analysis, personalized medicine, and targeted therapy. The present inventive concept addresses these limitations by synergistically combining the patented compositions with AI, IoT, blockchain, and microfluidics to create a more powerful system.

Detailed Description of the Inventive Concept

The inventive concept comprises a near IR, closed chain, sulfo-cyanine dye and a prostate specific membrane antigen ligand, which are integrated with emerging technologies such as AI, IoT, blockchain, and microfluidics. The AI module enables real-time image analysis, while the IoT-enabled imaging device facilitates remote monitoring and data collection. The blockchain-based tracking system ensures secure and transparent patient data management. The microfluidic device enables controlled release of the fusion compound, allowing for targeted therapy. The inventive concept can be implemented in various formats, including oral and injectable dosage forms, and can be tailored to individual patients' genetic profiles using 3D-printed implants.

Novelty and Inventive Step

The inventive concept's novelty lies in the synergistic integration of the patented compositions with emerging technologies, which enables real-time image analysis, personalized medicine, and targeted therapy. The inventive step lies in the unexpected combination of these technologies, which creates a more powerful system for visualizing, detecting, and treating prostate cancer.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept include using different types of dyes, ligands, or emerging technologies. Variations of the inventive concept include using the system for detecting and treating other types of cancer, or integrating the system with other medical devices and platforms.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the medical device and pharmaceutical industries, particularly in the areas of cancer diagnosis and treatment. The target market includes hospitals, clinics, and research institutions, as well as patients and healthcare providers.

CPC Classifications

SectionClassGroup
A A61 A61K49/0052
A A61 A61K9/0019
A A61 A61K49/0032
A A61 A61K49/0034
C C09 C09B23/0025
C C09 C09B23/0066
G G01 G01N33/57434

Original Patent Information

Patent NumberUS 11,857,645
TitleCompositions of near IR closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands
Assignee(s)INTUITIVE SURGICAL OPERATIONS, INC.