Synergistic Integration of Near IR, Closed Chain, Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands with Emerging Technologies

Publication ID: 24-11857645_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Integration of Near IR, Closed Chain, Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands with Emerging Technologies,” Published Technical Disclosure No. 24-11857645_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857645_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,645.

Summary of the Inventive Concept

The present inventive concept integrates near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands with emerging technologies such as AI, IoT, blockchain, and microfluidics to create a novel system for visualizing, detecting, and treating prostate cancer, enabling real-time image analysis, personalized medicine, and targeted therapy.

Background and Problem Solved

The original patent disclosed compositions of near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands for minimally invasive medical techniques. However, the patent's limitations included the lack of integration with emerging technologies, which limited its potential for real-time image analysis, personalized medicine, and targeted therapy. The present inventive concept addresses these limitations by synergistically combining the patented compositions with AI, IoT, blockchain, and microfluidics to create a more powerful system.

Detailed Description of the Inventive Concept

The inventive concept comprises a near IR, closed chain, sulfo-cyanine dye and a prostate specific membrane antigen ligand, which are integrated with emerging technologies such as AI, IoT, blockchain, and microfluidics. The AI module enables real-time image analysis, while the IoT-enabled imaging device facilitates remote monitoring and data collection. The blockchain-based tracking system ensures secure and transparent patient data management. The microfluidic device enables controlled release of the fusion compound, allowing for targeted therapy. The inventive concept can be implemented in various formats, including oral and injectable dosage forms, and can be tailored to individual patients' genetic profiles using 3D-printed implants.

Novelty and Inventive Step

The inventive concept's novelty lies in the synergistic integration of the patented compositions with emerging technologies, which enables real-time image analysis, personalized medicine, and targeted therapy. The inventive step lies in the unexpected combination of these technologies, which creates a more powerful system for visualizing, detecting, and treating prostate cancer.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept include using different types of dyes, ligands, or emerging technologies. Variations of the inventive concept include using the system for detecting and treating other types of cancer, or integrating the system with other medical devices and platforms.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the medical device and pharmaceutical industries, particularly in the areas of cancer diagnosis and treatment. The target market includes hospitals, clinics, and research institutions, as well as patients and healthcare providers.

CPC Classifications

SectionClassGroup
A A61 A61K49/0052
A A61 A61K9/0019
A A61 A61K49/0032
A A61 A61K49/0034
C C09 C09B23/0025
C C09 C09B23/0066
G G01 G01N33/57434

Field of Art

Medical imaging and diagnostic technologies, specifically focused on near-infrared molecular imaging for cancer detection and treatment, requiring expertise in pharmaceutical composition design, molecular imaging techniques, and interdisciplinary medical technologies

Person of Ordinary Skill (PHOSITA) Profile

A person with advanced training in biomedical engineering, chemistry, or medical imaging, possessing a PhD or equivalent professional experience, familiar with molecular imaging techniques, pharmaceutical formulation, and emerging medical technologies

Obviousness Rationale

A PHOSITA would recognize that integrating the source patent's near-infrared sulfo-cyanine dye compositions with emerging technologies represents a predictable application of known molecular imaging principles. The combination of established pharmaceutical compositions with AI, IoT, and microfluidic technologies would be a natural extension of existing medical imaging research. The PTD's variations demonstrate standard technological convergence in medical diagnostic approaches.

Obvious Combinations & Variations

Source Patent Element
Pharmaceutical composition with near-infrared closed chain sulfo-cyanine dyes for medical imaging
PTD Variation
Integration of AI module for real-time image analysis and interpretation
Obviousness Reasoning
Implementing AI for medical image analysis is a known technique in diagnostic technologies, representing a predictable enhancement to existing imaging methodologies
Source Patent Element
Dosage forms including oral and injectable compositions
PTD Variation
Microfluidic device for controlled release and targeted therapy
Obviousness Reasoning
Developing controlled-release mechanisms for pharmaceutical compositions is a standard approach in drug delivery research, representing an obvious optimization of existing dosage form technologies
Source Patent Element
Prostate specific membrane antigen (PSMA) ligand-based composition
PTD Variation
Blockchain-based tracking system for patient data management
Obviousness Reasoning
Implementing secure data management technologies in medical contexts is a predictable solution for addressing patient privacy and treatment tracking requirements
Source Patent Element
Near-infrared imaging composition for medical diagnostics
PTD Variation
IoT-enabled imaging device for remote monitoring and data collection
Obviousness Reasoning
Integrating Internet of Things technologies into medical imaging represents a standard technological progression in diagnostic and monitoring systems
Source Patent Element
Pharmaceutical composition with specific molecular targeting
PTD Variation
3D-printed personalized implants tailored to individual genetic profiles
Obviousness Reasoning
Personalized medicine approaches using advanced manufacturing techniques are a predictable evolution in targeted therapeutic strategies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857645 and the published technical disclosure, a person having ordinary skill in the art would find the claimed variations obvious, as they represent predictable combinations of known pharmaceutical composition technologies with emerging medical imaging and data management approaches. The disclosed variations demonstrate standard technological convergence and optimization strategies that would be apparent to a skilled practitioner in the field of molecular imaging and diagnostic technologies.

Original Patent Information

Patent NumberUS 11,857,645
TitleCompositions of near IR closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands
Assignee(s)INTUITIVE SURGICAL OPERATIONS, INC.