Specialized Near-Infrared Fluorescent Imaging Systems for High-Security, Disaster Relief, and Extreme Weather Environments

Publication ID: 24-11857645_0009_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Specialized Near-Infrared Fluorescent Imaging Systems for High-Security, Disaster Relief, and Extreme Weather Environments,” Published Technical Disclosure No. 24-11857645_0009_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857645_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,645.

Summary of the Inventive Concept

The present inventive concept adapts near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands for use in specialized, niche environments, including high-security facilities, disaster relief zones, and extreme weather conditions, enabling enhanced tissue visualization and guided medical procedures in these unique settings.

Background and Problem Solved

Minimally invasive medical techniques are increasingly important, but existing solutions may not be suitable for high-security, disaster relief, or extreme weather environments. The original patent disclosed compositions of near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands for tissue visualization, but did not address the specific challenges and requirements of these niche environments. The present inventive concept addresses these limitations by developing specialized systems and compositions for these unique settings.

Detailed Description of the Inventive Concept

The inventive concept comprises a range of specialized systems and compositions, including: a system for visualizing tissue in high-security environments, featuring a secure data transmission module; a method for disaster relief, utilizing a portable, ruggedized near-infrared illumination device; a composition for use in extreme weather conditions, incorporating a thermally-stable, waterproof excipient; a kit for high-altitude surgical procedures, including a portable, oxygen-enhanced near-infrared illumination device; and a system for remote, telemedicine-enabled surgical guidance, featuring a secure, real-time video transmission module. These specialized solutions enable medical professionals to effectively visualize tissue and guide medical procedures in challenging environments.

Novelty and Inventive Step

The present inventive concept is novel and non-obvious in its adaptation of near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands for use in high-security, disaster relief, and extreme weather environments. The inventive concept's specialized systems and compositions address specific challenges and requirements of these niche environments, providing a unique solution not disclosed in the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include: integrating the near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands with advanced robotics or artificial intelligence for enhanced tissue visualization and guidance; developing specialized training programs for medical professionals operating in high-security, disaster relief, or extreme weather environments; or creating modular, adaptable systems that can be easily customized for specific environments and applications.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in various industries, including: high-security facilities, such as government agencies or correctional institutions; disaster relief organizations and emergency response teams; extreme weather environments, such as arctic or desert research stations; and telemedicine platforms providing remote surgical guidance. The market for these specialized systems and compositions is substantial, with potential applications in a wide range of medical procedures and settings.

CPC Classifications

SectionClassGroup
A A61 A61K49/0052
A A61 A61K9/0019
A A61 A61K49/0032
A A61 A61K49/0034
C C09 C09B23/0025
C C09 C09B23/0066
G G01 G01N33/57434

Field of Art

Medical imaging and pharmaceutical compositions, specifically near-infrared fluorescent dye systems for tissue visualization and diagnostic applications, requiring advanced knowledge of organic chemistry, medical imaging technologies, and pharmaceutical formulation

Person of Ordinary Skill (PHOSITA) Profile

A researcher or medical professional with advanced degrees in chemistry, biomedical engineering, or pharmaceutical sciences, possessing expertise in fluorescent imaging techniques, drug delivery systems, and medical device design

Obviousness Rationale

A PHOSITA would recognize that adapting the source patent's near-infrared sulfo-cyanine dye compositions to specialized environmental contexts represents a predictable extension of existing medical imaging technologies. The fundamental chemical composition remains substantially unchanged, with modifications primarily focusing on application-specific packaging, transmission, and environmental adaptation. These variations represent standard engineering design choices within the established technological framework of medical imaging systems.

Obvious Combinations & Variations

Source Patent Element
Pharmaceutical composition with near-infrared closed chain sulfo-cyanine dyes
PTD Variation
Integrating secure data transmission modules for high-security environment imaging
Obviousness Reasoning
Adding secure communication to existing medical imaging technology represents a known technique for expanding diagnostic capabilities in sensitive environments
Source Patent Element
Sterile, non-toxic pharmaceutical dosage forms
PTD Variation
Developing ruggedized, portable near-infrared illumination devices for disaster relief
Obviousness Reasoning
Adapting existing medical imaging compositions for extreme environmental conditions is a predictable solution using standard engineering design principles
Source Patent Element
Injectable and oral dosage forms of sulfo-cyanine dye compounds
PTD Variation
Creating thermally-stable, waterproof excipients for extreme weather applications
Obviousness Reasoning
Modifying pharmaceutical excipients to enhance environmental stability represents a routine optimization within pharmaceutical formulation practices
Source Patent Element
Unit dosage forms with specific concentration ranges
PTD Variation
Developing high-altitude surgical procedure kits with oxygen-enhanced illumination
Obviousness Reasoning
Adjusting medical imaging systems for altitude-specific challenges involves predictable engineering modifications known to those skilled in medical device design
Source Patent Element
Pharmaceutical composition for tissue visualization
PTD Variation
Implementing telemedicine-enabled surgical guidance systems with real-time video transmission
Obviousness Reasoning
Integrating communication technologies with existing medical imaging systems represents a standard technological evolution in medical diagnostics
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857645 and the published technical disclosure, a person of ordinary skill in the art would find the claimed variations obvious and anticipated, as the disclosed adaptations represent predictable extensions of existing near-infrared fluorescent imaging technologies through routine engineering modifications and standard design choices within the medical imaging domain.

Original Patent Information

Patent NumberUS 11,857,645
TitleCompositions of near IR closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands
Assignee(s)INTUITIVE SURGICAL OPERATIONS, INC.