Phospholipid-Based Sensors for Industrial, Food, Water, Pharmaceutical, and Soil Quality Monitoring

Publication ID: 24-11857646_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Phospholipid-Based Sensors for Industrial, Food, Water, Pharmaceutical, and Soil Quality Monitoring,” Published Technical Disclosure No. 24-11857646_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857646_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,646.

Summary of the Inventive Concept

The inventive concept leverages the core technology of the original patent to develop novel phospholipid-based sensors for detecting divalent metal cations in various industries, enabling real-time monitoring and quality control.

Background and Problem Solved

The original patent disclosed improved methods for preparing phospholipid-based ultrasound contrast agents. However, the technology's potential extends beyond medical imaging applications. The inventive concept addresses the need for efficient, real-time monitoring of divalent metal cations in industrial processes, food quality, water purity, pharmaceutical formulations, and soil fertility.

Detailed Description of the Inventive Concept

The phospholipid-based sensors utilize the same principles of divalent metal cation susceptibility as the original patent. By adapting the phospholipid blend and formulation to specific industrial, food, water, pharmaceutical, and soil quality monitoring applications, the sensors can detect calcium and/or magnesium levels, providing real-time alerts to operators, quality control personnel, or farmers. The sensors can be integrated into existing monitoring systems or used as standalone devices.

Novelty and Inventive Step

The new claims introduce an entirely new field of application for the core technology, leveraging the unexpected finding of divalent metal cation susceptibility to develop novel sensors for quality monitoring in various industries. This inventive step expands the technology's scope beyond medical imaging, demonstrating a new, non-obvious use for the phospholipid-based formulations.

Alternative Embodiments and Variations

Alternative embodiments may include modifying the phospholipid blend to enhance sensitivity or selectivity for specific divalent metal cations, incorporating additional detection mechanisms, or developing miniaturized or portable sensor devices. Variations may also include adapting the sensors for use in other industries, such as environmental monitoring or cosmetics.

Potential Commercial Applications and Market

The phospholipid-based sensors have significant commercial potential in various industries, including industrial process control, food safety, water treatment, pharmaceutical quality control, and agricultural soil monitoring. The market for these sensors is substantial, with potential customers including industrial manufacturers, food producers, water treatment facilities, pharmaceutical companies, and farmers.

CPC Classifications

SectionClassGroup
A A61 A61K49/223
A A61 A61B8/481
A A61 A61K49/226
A A61 A61K49/227
C C07 C07F9/09
C C07 C07F9/106

Field of Art

Biomedical engineering and analytical chemistry, focusing on phospholipid-based sensing technologies, with expertise in ultrasound contrast agents, molecular detection systems, and material science interfaces

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degree in biomedical engineering, chemistry, or related field, possessing knowledge of phospholipid formulations, sensor design, and interdisciplinary applications of molecular detection technologies

Obviousness Rationale

A PHOSITA would recognize the inherent adaptability of the phospholipid-based technology from the source patent, understanding that the core principle of divalent metal cation sensitivity could be readily translated across multiple industrial and scientific domains. The fundamental mechanism of phospholipid interaction with metal ions provides a natural pathway for developing sensing technologies beyond medical imaging. The disclosed sensor applications represent predictable extensions of the original ultrasound contrast agent technology, leveraging the same underlying molecular principles.

Obvious Combinations & Variations

Source Patent Element
Phospholipid blend comprising DPPA, DPPC, and MPEG5000-DPPE with sensitivity to calcium and magnesium
PTD Variation
Adapting the phospholipid blend for detecting metal cations in industrial, food, water, pharmaceutical, and soil quality monitoring systems
Obviousness Reasoning
Known technique of repurposing molecular detection mechanisms across different technical domains, with predictable results based on established phospholipid interaction principles
Source Patent Element
Method of detecting divalent metal cation interactions with phospholipid formulations
PTD Variation
Creating real-time sensor systems that provide alerts based on metal cation detection
Obviousness Reasoning
Predictable application of existing detection mechanism to create monitoring technologies, representing a straightforward design choice for a PHOSITA
Source Patent Element
Understanding of phospholipid susceptibility to metal cations in ultrasound contrast agents
PTD Variation
Developing sensors that correlate metal cation levels with quality indicators in various domains
Obviousness Reasoning
Finite set of logical extensions of the original technology, representing an obvious combination of known techniques with predictable scientific outcomes
Source Patent Element
Phospholipid blend formation techniques using methanol and toluene
PTD Variation
Adapting formulation techniques for creating sensitive detection platforms across different industrial contexts
Obviousness Reasoning
Known method of transferring molecular preparation techniques between related technological domains, representing a standard engineering approach
Source Patent Element
Concentration-dependent interactions of divalent metal cations with phospholipid structures
PTD Variation
Developing quantitative sensing mechanisms that provide precise metal cation level measurements
Obviousness Reasoning
Predictable scientific progression utilizing the inherent sensitivity of phospholipid molecular structures to create more advanced detection technologies
35 U.S.C. § 103 Summary: Based on US Patent 11857646's disclosure of phospholipid-based ultrasound contrast agent technologies, the present publication demonstrates that a Person Having Ordinary Skill In The Art would find the proposed sensor technologies obvious and non-inventive, as they represent straightforward extensions of the fundamental molecular detection principles disclosed in the source patent, thereby constituting valid prior art that would render subsequent similar claims obvious and unpatentable.

Original Patent Information

Patent NumberUS 11,857,646
TitleMethods for making ultrasound contrast agents
Assignee(s)Lantheus Medical Imaging, Inc.