Phospholipid-Based Ultrasound Contrast Agents for Novel Applications

Publication ID: 24-11857646_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Phospholipid-Based Ultrasound Contrast Agents for Novel Applications,” Published Technical Disclosure No. 24-11857646_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857646_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,646.

Summary of the Inventive Concept

This inventive concept explores the application of phospholipid-based ultrasound contrast agents in entirely new industries, including cosmetics, food, athletics, and pharmaceuticals, enabling innovative solutions for personalized skin care, edible products, athletic performance monitoring, and customized pharmaceutical dosages.

Background and Problem Solved

The original patent disclosed methods for preparing phospholipid-based ultrasound contrast agents for medical imaging applications. However, these agents have untapped potential in other fields. This inventive concept addresses the limitation of the original patent by expanding the scope of these agents to novel applications, leveraging their unique properties to create new solutions.

Detailed Description of the Inventive Concept

The new claims encompass methods and systems for utilizing phospholipid-based ultrasound contrast agents in various industries. For instance, Claim 1 describes a method for preparing a personalized cosmetic formulation using these agents, enabling tailored skin texture and appearance. Claim 2 outlines a system for non-invasive skin analysis, while Claim 3 details a method for creating edible, customizable food products. Claims 4 and 5 describe devices for real-time athletic performance monitoring and generating personalized, 3D-printed pharmaceutical dosage forms, respectively. These inventive concepts harness the properties of phospholipid-based ultrasound contrast agents to create novel solutions with significant commercial potential.

Novelty and Inventive Step

The novelty of this inventive concept lies in the unexpected application of phospholipid-based ultrasound contrast agents in industries unrelated to medical imaging. The inventive step is the recognition of the agents' versatility and the development of new methods and systems that capitalize on their unique properties to create innovative solutions.

Alternative Embodiments and Variations

Alternative embodiments of this inventive concept could include the use of different phospholipid blends, varying concentrations of divalent metal cations, or alternative solvents. Additionally, the inventive concept could be adapted for use in other industries, such as biotechnology or environmental monitoring.

Potential Commercial Applications and Market

The potential commercial applications of this inventive concept are vast, with opportunities in the cosmetics, food, athletics, and pharmaceutical industries. The market demand for personalized, innovative solutions in these fields is significant, and the ability to leverage phospholipid-based ultrasound contrast agents to create new products and services could lead to substantial revenue growth and market share.

CPC Classifications

SectionClassGroup
A A61 A61K49/223
A A61 A61B8/481
A A61 A61K49/226
A A61 A61K49/227
C C07 C07F9/09
C C07 C07F9/106

Field of Art

Biomedical engineering and pharmaceutical formulation, specifically focusing on lipid-based contrast agents and microsphere technologies, with expertise in chemical engineering, ultrasound imaging, and advanced material preparation techniques

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degrees in chemistry, biomedical engineering, or pharmaceutical sciences, possessing knowledge of lipid chemistry, microsphere preparation, and cross-industry applications of medical technologies

Obviousness Rationale

A PHOSITA would recognize that the fundamental properties of phospholipid-based ultrasound contrast agents inherently suggest broader applications beyond medical imaging. The source patent's detailed methodology for preparing phospholipid microspheres provides a clear technological foundation that could be readily adapted to alternative industrial uses by applying standard engineering design principles and known techniques of material modification.

Obvious Combinations & Variations

Source Patent Element
Phospholipid blend preparation method using DPPA, DPPC, and MPEG5000-DPPE with specific divalent metal cation concentrations
PTD Variation
Adapting the phospholipid microsphere preparation for cosmetic skin texture formulations
Obviousness Reasoning
A PHOSITA would recognize that the microsphere preparation techniques are transferable across industries, with predictable results in creating tailored material properties
Source Patent Element
Ultrasound contrast agent microsphere composition with controlled metal cation concentrations
PTD Variation
Using phospholipid microspheres for non-invasive performance monitoring in athletics
Obviousness Reasoning
The inherent imaging and tracking capabilities of the microspheres suggest obvious extension to performance monitoring applications using known ultrasound technologies
Source Patent Element
Phospholipid suspension formation techniques involving methanol and toluene solvents
PTD Variation
Creating edible food products incorporating phospholipid microspheres
Obviousness Reasoning
A PHOSITA would understand that food-grade phospholipid preparations are a predictable variation given the source patent's detailed chemical preparation methods
Source Patent Element
Precise control of phospholipid blend composition and metal cation concentrations
PTD Variation
Generating personalized 3D-printed pharmaceutical dosage forms
Obviousness Reasoning
The source patent's emphasis on precise formulation control directly suggests obvious applications in customized pharmaceutical delivery systems
35 U.S.C. § 103 Summary: Based on US Patent 11857646's comprehensive disclosure of phospholipid-based ultrasound contrast agent preparation methods, the present publication demonstrates that the claimed variations represent obvious extensions of the prior art, employing standard engineering design choices and predictable technological adaptations that would be readily conceived by a person having ordinary skill in the art of biomedical and pharmaceutical engineering.

Original Patent Information

Patent NumberUS 11,857,646
TitleMethods for making ultrasound contrast agents
Assignee(s)Lantheus Medical Imaging, Inc.