Enhanced Multivalent Molecules for Molecular Imaging and Radioimmunotherapy

This invention relates to improved multivalent molecules for molecular imaging and/or targeted drug delivery, featuring enhanced stability, specificity, and binding affinity. The inventive concept addresses the limitations of existing multivalent molecules by introducing novel chelators, detectable labels, and spacer lengths.

The original patent disclosed a multivalent molecular imaging and/or targeted drug delivery method, wherein the multivalent molecule targeting different biomarkers carries the imaging label and/or drug. However, the existing method has limitations in terms of stability, specificity, and binding affinity. The new inventive concept solves these problems by introducing improved chelators, detectable labels, and optimized spacer lengths.

The enhanced multivalent molecule comprises a chelator with improved stability and specificity, a detectable label or therapeutic agent with enhanced binding affinity, and a novel spacer length optimized for improved cellular uptake and retention. The chelator can be selected from NOTA, NETA, CB-TE2A, CB-TE1A1P, TETA, Pycu2A, DiAmSar, DOTA, DTP, or other suitable chelating cores. The detectable label can be a radioactive isotope, a dye molecule, or other suitable label. The novel spacer length can be optimized using a high-throughput screening method. The inventive concept also encompasses a system, method, and kit for molecular imaging and/or therapy using the enhanced multivalent molecule.

The new inventive concept introduces novel chelators, detectable labels, and optimized spacer lengths, which are not obvious from the original patent. The improved stability, specificity, and binding affinity of the enhanced multivalent molecule provide a significant advantage over existing methods.

Alternative embodiments of the inventive concept include using different chelating cores, detectable labels, or spacer lengths. The inventive concept can also be adapted for use in various applications, such as cancer diagnosis and treatment, or infectious disease imaging.

The enhanced multivalent molecule has significant commercial potential in the fields of molecular imaging and targeted drug delivery. The inventive concept can be used in various industries, including pharmaceuticals, biotechnology, and medical imaging.