Multivalent Molecule-Based Solutions for Diverse Industries

Publication ID: 24-11857648_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Multivalent Molecule-Based Solutions for Diverse Industries,” Published Technical Disclosure No. 24-11857648_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857648_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,648.

Summary of the Inventive Concept

This inventive concept expands the core technology of multivalent molecules to tackle diverse problems in agriculture, environmental monitoring, medical devices, and water quality, offering targeted solutions for pest control, fungal infection detection, biofilm treatment, and pollutant monitoring.

Background and Problem Solved

The original patent focused on molecular imaging and radioimmunotherapy, but its multivalent molecule technology has broader potential. This inventive concept addresses the limitations of existing solutions in various industries by leveraging the versatility of multivalent molecules to target specific biomarkers, enabling precise detection and treatment of diverse problems.

Detailed Description of the Inventive Concept

The inventive concept involves designing multivalent molecules with a first peptide and a chelator, which can be loaded with a pesticide, detectable label, or other payloads. A second peptide targets specific biomarkers in various industries, such as agricultural pests, fungal infections in plants, waterborne pathogens, biofilm-forming microorganisms, or environmental pollutants. The multivalent molecule's modular design enables easy adaptation to different applications, ensuring precise detection and treatment of targeted problems.

Novelty and Inventive Step

The new claims introduce a paradigm shift by applying the core multivalent molecule technology to entirely new industries and use cases, demonstrating a non-obvious expansion of the original patent's scope. The inventive step lies in the recognition of the technology's versatility and its adaptation to diverse problem domains.

Alternative Embodiments and Variations

Alternative embodiments could involve varying the chelator, peptide sequences, or payload types to suit specific industry requirements. Variations may include using different detectable labels, such as fluorescent dyes or radiolabels, or incorporating additional components to enhance targeting efficiency or payload delivery.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential in various industries, including agriculture, environmental monitoring, medical devices, and water quality management. The market demand for targeted solutions in these areas is substantial, and the inventive concept's versatility and adaptability make it an attractive opportunity for companies seeking to address diverse challenges.

CPC Classifications

SectionClassGroup
A A61 A61K51/082
A A61 A61K9/51
A A61 A61K47/6893
A A61 A61K51/1027
C C07 C07D255/02
C C07 C07D257/02
C C07 C07K7/06
C C07 C07K7/64
C C07 C07K16/30
G G01 G01N33/5008
G G01 G01N33/60
C C07 C07K2319/00

Field of Art

Molecular imaging, targeted drug delivery, and biomarker detection technologies, encompassing biochemistry, molecular biology, and chemical engineering with expertise in peptide design, chelator chemistry, and diagnostic/therapeutic molecular systems

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in chemistry or molecular biology, experienced in designing multivalent molecular constructs, familiar with chelator chemistry, radiolabeling techniques, and biomarker targeting strategies

Obviousness Rationale

A PHOSITA would recognize the source patent's multivalent molecular imaging technology as a versatile platform that could be readily adapted to diverse application domains by systematically substituting targeting peptides, payloads, and detection modalities while maintaining the core molecular architecture and dimerization strategies disclosed in the original patent.

Obvious Combinations & Variations

Source Patent Element
Multivalent molecule with first peptide, chelator, and detectable label
PTD Variation
Adapting the molecular construct to agricultural pest control by replacing medical targeting peptides with pest-specific biomarker peptides
Obviousness Reasoning
Predictable variation involving routine peptide sequence modification to achieve targeted molecular recognition in a new technical domain
Source Patent Element
Chelator selection from NOTA, NETA, CB-TE2A, DOTA compound classes
PTD Variation
Utilizing identical chelator chemistries for loading pesticides or environmental pollutant detection molecules
Obviousness Reasoning
Known technique of repurposing established molecular scaffolds for alternative payload delivery applications
Source Patent Element
Detectable labels including fluorescent dyes like Cy3, Cy5, Alexa dyes
PTD Variation
Applying identical fluorescent labeling strategies for fungal infection detection and water quality monitoring
Obviousness Reasoning
Finite set of well-characterized detection technologies that can be systematically applied across different diagnostic contexts
Source Patent Element
Molecular imaging compound with two-peptide targeting strategy
PTD Variation
Extending two-peptide construct to biofilm detection on medical devices using biomarker-specific peptide sequences
Obviousness Reasoning
Obvious extension of known molecular targeting approach to a related technical problem with predictable implementation
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. § 103, the variations disclosed herein would have been obvious to a person of ordinary skill in the art at the time of invention, as the multivalent molecular construct described in US Patent 11857648 provides a foundational technological platform that can be systematically adapted across diverse technical domains through routine peptide sequence modification, payload substitution, and targeting strategies, thereby rendering subsequent claims involving such variations prima facie obvious.

Original Patent Information

Patent NumberUS 11,857,648
TitleDimerization strategies and compounds for molecular imaging and/or radioimmunotherapy
Assignee(s)UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION