Multimodal Molecular Imaging and Therapy Platform

Publication ID: 24-11857648_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Multimodal Molecular Imaging and Therapy Platform,” Published Technical Disclosure No. 24-11857648_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857648_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,648.

Summary of the Inventive Concept

A next-generation platform for personalized medicine, integrating targeted molecular imaging and therapy compounds, real-time monitoring, and adaptive treatment optimization, enabling precise and effective disease diagnosis and treatment.

Background and Problem Solved

The original patent disclosed a multivalent molecular imaging and/or targeted drug delivery method, but it had limitations in terms of real-time monitoring and adaptive treatment optimization. The new inventive concept addresses these limitations by introducing a multimodal platform that co-administers targeted molecular imaging and therapy compounds, enabling real-time monitoring and adaptive treatment optimization.

Detailed Description of the Inventive Concept

The multimodal platform consists of a targeted molecular imaging compound and a targeted therapeutic compound, designed to target the same biomarker on a biological subject. The platform enables real-time monitoring of the biological subject using a detection device, and the detection data is used to optimize the administration of the targeted therapeutic compound. The platform can be used for personalized medicine, where the targeted molecular imaging compound is administered to a biological subject, detected using a detection device, and the detection data is used to select a targeted therapeutic compound for treating the biological subject.

Novelty and Inventive Step

The new inventive concept introduces the concept of real-time monitoring and adaptive treatment optimization, which is not present in the original patent. The co-administration of targeted molecular imaging and therapy compounds, and the use of detection data to optimize treatment, are novel and non-obvious features that provide a significant improvement over the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the multimodal platform could include the use of different types of detection devices, such as MRI or PET scanners, or the use of different types of targeted molecular imaging and therapy compounds. Variations of the platform could also include the integration of artificial intelligence or machine learning algorithms to optimize treatment based on detection data.

Potential Commercial Applications and Market

The multimodal platform has significant commercial potential in the fields of personalized medicine, cancer treatment, and molecular imaging. The platform could be used in hospitals and research institutions, and could be marketed to pharmaceutical companies and biotechnology companies developing targeted therapies.

CPC Classifications

SectionClassGroup
A A61 A61K51/082
A A61 A61K9/51
A A61 A61K47/6893
A A61 A61K51/1027
C C07 C07D255/02
C C07 C07D257/02
C C07 C07K7/06
C C07 C07K7/64
C C07 C07K16/30
G G01 G01N33/5008
G G01 G01N33/60
C C07 C07K2319/00

Original Patent Information

Patent NumberUS 11,857,648
TitleDimerization strategies and compounds for molecular imaging and/or radioimmunotherapy
Assignee(s)UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION