Multivalent Molecular Imaging and Therapy for Novel Applications

Publication ID: 24-11857648_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Multivalent Molecular Imaging and Therapy for Novel Applications,” Published Technical Disclosure No. 24-11857648_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857648_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,648.

Summary of the Inventive Concept

This inventive concept leverages the core technology of multivalent molecular imaging and therapy to address pressing needs in water quality monitoring, food safety, neurological disorder diagnosis, environmental pollutant detection, and agricultural product biomarker detection.

Background and Problem Solved

The original patent's multivalent molecular imaging and therapy approach has shown promise in various biomedical applications. However, its potential extends beyond the original scope. This inventive concept tackles the limitations of current methods in diverse fields, where the ability to target multiple biomarkers with a single molecule can revolutionize detection, diagnosis, and monitoring.

Detailed Description of the Inventive Concept

The new claims introduce the application of multivalent molecular imaging and therapy to novel fields, including water quality monitoring, food safety, neurological disorder diagnosis, environmental pollutant detection, and agricultural product biomarker detection. These claims describe systems, methods, and kits that utilize the core technology to target specific biomarkers associated with waterborne pathogens, contaminants in food products, neurological disorders, environmental pollutants, and agricultural products. The multivalent molecules carry detectable labels, enabling the detection and monitoring of these biomarkers.

Novelty and Inventive Step

The novelty of this inventive concept lies in the unexpected application of the original patent's multivalent molecular imaging and therapy approach to entirely new industries and problems. The inventive step is the recognition of the potential for this technology to be adapted and modified to address the specific needs of these novel fields.

Alternative Embodiments and Variations

Alternative embodiments of this inventive concept could include the use of different types of detectable labels, varying the structure and composition of the multivalent molecules, or integrating the technology with existing detection systems. Variations could also involve adapting the technology for use in other fields, such as veterinary medicine or biodefense.

Potential Commercial Applications and Market

The commercial potential of this inventive concept is significant, with applications in water quality monitoring, food safety, neurological disorder diagnosis, environmental pollutant detection, and agricultural product biomarker detection. The target industries include environmental monitoring, food processing, pharmaceuticals, and agriculture, with potential market sizes in the billions of dollars.

CPC Classifications

SectionClassGroup
A A61 A61K51/082
A A61 A61K9/51
A A61 A61K47/6893
A A61 A61K51/1027
C C07 C07D255/02
C C07 C07D257/02
C C07 C07K7/06
C C07 C07K7/64
C C07 C07K16/30
G G01 G01N33/5008
G G01 G01N33/60
C C07 C07K2319/00

Field of Art

Molecular imaging, radiopharmaceuticals, and targeted therapeutic compounds, involving advanced chemical synthesis, peptide engineering, and biomarker detection technologies

Person of Ordinary Skill (PHOSITA) Profile

A PhD-level researcher with expertise in medicinal chemistry, radiochemistry, or bioengineering, possessing advanced knowledge of chelation techniques, molecular labeling, and biomarker targeting strategies

Obviousness Rationale

A PHOSITA would recognize that the core multivalent molecular imaging technology disclosed in the source patent represents a versatile platform that can be readily adapted to multiple application domains by systematically replacing biomarker targets and detection modalities. The fundamental molecular design principles remain consistent across different fields, allowing predictable extension of the original technology. The modular nature of the molecular imaging approach inherently supports broad technological translation.

Obvious Combinations & Variations

Source Patent Element
Multivalent molecule with chelator and detectable label targeting specific biomarkers
PTD Variation
Applying the molecular imaging technique to water quality monitoring by targeting waterborne pathogen biomarkers
Obviousness Reasoning
Known technique of adapting molecular targeting strategies to new detection contexts, with predictable results in biomarker identification
Source Patent Element
Detectable labels including Cy3, Cy5, Alexa dyes, and radioisotopes
PTD Variation
Utilizing identical labeling strategies for environmental pollutant and agricultural product biomarker detection
Obviousness Reasoning
Established interchangeability of detection labels across different biological detection applications, representing a routine design choice
Source Patent Element
Peptide-based targeting mechanism with chelating cores like NOTA, DOTA
PTD Variation
Extending peptide targeting to neurological disorder biomarker identification
Obviousness Reasoning
Predictable application of known molecular targeting principles to a new diagnostic context, representing a standard technological translation
Source Patent Element
Compound comprising first peptide, second peptide, and chelator
PTD Variation
Modifying molecular structure to detect food product contaminant biomarkers
Obviousness Reasoning
Routine engineering modification following established molecular design principles, with expectation of successful adaptation
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. § 103, the variations disclosed herein would have been obvious to a person having ordinary skill in the art at the time of invention, as taught by US Patent 11857648, by applying known molecular imaging strategies to novel detection contexts through predictable combinations of existing technological elements, thereby rendering subsequent claims of novelty anticipated and non-patentable.

Original Patent Information

Patent NumberUS 11,857,648
TitleDimerization strategies and compounds for molecular imaging and/or radioimmunotherapy
Assignee(s)UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION