Specialized Silk Protein Fragment Compositions for Niche Applications

Publication ID: 24-11857663_0004_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Specialized Silk Protein Fragment Compositions for Niche Applications,” Published Technical Disclosure No. 24-11857663_0004_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857663_0004_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,663.

Summary of the Inventive Concept

The present inventive concept adapts the original silk protein fragment compositions for specific, narrow markets or unique operational environments, providing tailored solutions for high-security needs, disaster relief, extreme weather conditions, biodegradable packaging, and medical implants.

Background and Problem Solved

The original patent disclosed silk protein fragment compositions with varying molecular weights and polydispersity. However, these compositions may not be suitable for specific, demanding applications. The present inventive concept addresses this limitation by developing specialized silk protein fragment compositions that cater to niche markets, ensuring optimal performance in extreme conditions.

Detailed Description of the Inventive Concept

The new inventive concept comprises a range of silk protein fragment compositions, each tailored to a specific application. For disaster relief, the composition has an average weight average molecular weight ranging from about 6 kDa to about 16 kDa, and a polydispersity ranging from about 1.5 and about 3.0. For high-security applications, the composition is produced using a pure and highly scalable silk protein fragment mixture solution, with an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, and a polydispersity ranging from about 1.5 and about 3.0. For extreme temperatures, the composition has an average weight average molecular weight ranging from about 35 kDa to about 40 kDa, and a polydispersity ranging from about 1.5 and about 3.0. For biodegradable packaging, the composition has an average weight average molecular weight ranging from about 6 kDa to about 16 kDa, and a polydispersity ranging from about 1.5 and about 3.0. For medical implants, the composition is produced using a pure and highly scalable silk protein fragment mixture solution, with an average weight average molecular weight ranging from about 40 kDa to about 45 kDa, and a polydispersity ranging from about 1.5 and about 3.0.

Novelty and Inventive Step

The new inventive concept's novelty lies in its adaptation of the original silk protein fragment compositions for specific, niche applications. The inventive step is the development of specialized compositions that cater to the unique requirements of these applications, ensuring optimal performance in extreme conditions.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include varying the molecular weight and polydispersity of the silk protein fragment compositions to suit different applications. Additionally, the compositions could be blended with other materials to enhance their performance in specific environments.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in various industries, including disaster relief, high-security, extreme weather, biodegradable packaging, and medical implants. The targeted markets include government agencies, private security firms, extreme weather equipment manufacturers, biodegradable packaging companies, and medical device manufacturers.

CPC Classifications

SectionClassGroup
A A61 A61K8/64
A A45 A45D33/00
A A61 A61K8/02
A A61 A61K8/0216
A A61 A61K8/042
A A61 A61K8/19
A A61 A61K8/27
A A61 A61K8/29
A A61 A61K8/365
A A61 A61K8/4953
A A61 A61K8/676
A A61 A61K8/735
A A61 A61K8/922
A A61 A61K8/97
A A61 A61K8/9789
A A61 A61K8/9794
A A61 A61K8/987
A A61 A61K9/08
A A61 A61K31/375
A A61 A61K38/00
A A61 A61K38/012
A A61 A61K45/06
A A61 A61K47/02
A A61 A61K47/12
A A61 A61K47/36
A A61 A61Q17/04
A A61 A61Q19/00
A A61 A61Q19/007
A A61 A61Q19/02
A A61 A61Q19/08
C C07 C07K1/12
C C07 C07K14/43586
A A61 A61K2800/591
A A61 A61K2800/72
A A61 A61K2800/74
A A61 A61K2800/75

Field of Art

Biomaterials and protein engineering, with a focus on silk protein compositions for medical, industrial, and specialized applications. Expertise requires advanced knowledge of protein chemistry, materials science, and processing techniques for protein-based materials

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with a PhD in materials science, bioengineering, or chemical engineering, with specialized experience in protein extraction, molecular weight characterization, and materials processing techniques for biomaterials

Obviousness Rationale

A person having ordinary skill would recognize that the source patent's silk protein fragment compositions provide a foundational framework that can be readily adapted for specific applications by systematically varying molecular weight and processing parameters. The PTD demonstrates predictable variations within the known range of silk protein fragment processing, using standard materials science techniques to tailor compositions for different environmental and functional requirements. These modifications represent routine optimization that would be apparent to a skilled practitioner familiar with protein engineering and materials adaptation strategies.

Obvious Combinations & Variations

Source Patent Element
Lyophilized silk fibroin protein fragments with molecular weights between 17-45 kDa
PTD Variation
Targeted molecular weight ranges for specific applications like disaster relief (6-16 kDa), high-security (17-38 kDa), and medical implants (40-45 kDa)
Obviousness Reasoning
A PHOSITA would recognize that molecular weight selection is a predictable design parameter for modifying material properties, with finite and known ranges of optimization for different applications
Source Patent Element
Compositions substantially devoid of sericin
PTD Variation
Specialized processing techniques for generating pure silk protein fragment solutions for niche markets
Obviousness Reasoning
Removing sericin and generating pure protein solutions is a known technique in silk protein processing, representing a standard approach to material purification and performance enhancement
Source Patent Element
Reconstitutable silk protein fragment solutions
PTD Variation
Compositions adapted for extreme temperatures, high-security, and specific environmental conditions
Obviousness Reasoning
Modifying protein compositions for environmental resilience is a predictable extension of known materials science techniques, involving routine experimentation with molecular parameters
Source Patent Element
Lyophilization and solvent reconstitution methods
PTD Variation
Generating scalable silk protein fragment mixture solutions with controlled polydispersity
Obviousness Reasoning
Controlling molecular weight distribution and generating pure protein solutions are standard techniques in protein engineering, representing expected optimization strategies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857663, the present publication demonstrates that variations in silk protein fragment compositions for specialized applications would be obvious to a person having ordinary skill in the art. The disclosed modifications represent predictable extensions of known protein processing techniques, involving routine optimization of molecular weight, purity, and environmental adaptability within established parameters of silk protein materials engineering.

Original Patent Information

Patent NumberUS 11,857,663
TitleStable silk protein fragment compositions
Assignee(s)EVOLVED BY NATURE, INC.