Silk Protein Fragment Compositions for Diverse Industrial Applications

Publication ID: 24-11857663_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Silk Protein Fragment Compositions for Diverse Industrial Applications,” Published Technical Disclosure No. 24-11857663_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857663_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,663.

Summary of the Inventive Concept

This inventive concept leverages the core technology of stable silk protein fragment compositions to expand into new industries and use cases, including 3D printing, implantable medical devices, biodegradable packaging, agricultural films, and personalized skincare products.

Background and Problem Solved

The original patent disclosed stable silk protein fragment compositions for medical applications. However, the limitations of the original patent include the focus on medical uses, leaving unexplored opportunities for applying this technology to other industries. This inventive concept addresses the problem of limited industrial applicability by adapting the core technology to diverse new use cases.

Detailed Description of the Inventive Concept

The new inventive concept involves applying the stable silk protein fragment compositions to various industrial applications. For instance, in 3D printing, the compositions enable the creation of customized prosthetic limbs with enhanced biocompatibility. In implantable medical devices, the compositions generate bioactive coatings to enhance tissue integration and reduce inflammation. The compositions can also be used as biodegradable packaging materials, agricultural films, and personalized skincare products, offering unique benefits in each field. The silk protein fragments' tunable molecular weight and polydispersity enable customization for specific applications.

Novelty and Inventive Step

The new claims introduce novel and non-obvious applications of the stable silk protein fragment compositions, expanding beyond the original medical focus. The inventive step lies in recognizing the potential for these compositions to solve problems in diverse industries and developing tailored solutions to address these needs.

Alternative Embodiments and Variations

Alternative embodiments of this inventive concept could include adapting the silk protein fragment compositions for use in textiles, cosmetics, or food packaging. Variations may involve modifying the composition's molecular weight, polydispersity, or solvent to suit specific industrial requirements.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential across multiple industries, including healthcare, agriculture, consumer goods, and manufacturing. The target market includes companies seeking sustainable, biocompatible, and customizable materials for their products, as well as consumers demanding environmentally friendly and effective solutions.

CPC Classifications

SectionClassGroup
A A61 A61K8/64
A A45 A45D33/00
A A61 A61K8/02
A A61 A61K8/0216
A A61 A61K8/042
A A61 A61K8/19
A A61 A61K8/27
A A61 A61K8/29
A A61 A61K8/365
A A61 A61K8/4953
A A61 A61K8/676
A A61 A61K8/735
A A61 A61K8/922
A A61 A61K8/97
A A61 A61K8/9789
A A61 A61K8/9794
A A61 A61K8/987
A A61 A61K9/08
A A61 A61K31/375
A A61 A61K38/00
A A61 A61K38/012
A A61 A61K45/06
A A61 A61K47/02
A A61 A61K47/12
A A61 A61K47/36
A A61 A61Q17/04
A A61 A61Q19/00
A A61 A61Q19/007
A A61 A61Q19/02
A A61 A61Q19/08
C C07 C07K1/12
C C07 C07K14/43586
A A61 A61K2800/591
A A61 A61K2800/72
A A61 A61K2800/74
A A61 A61K2800/75

Field of Art

Biomaterials and protein engineering, with expertise in silk protein processing, molecular weight manipulation, and advanced material applications across medical, industrial, and consumer product domains

Person of Ordinary Skill (PHOSITA) Profile

A skilled researcher with advanced degrees in materials science, bioengineering, or chemical engineering, possessing knowledge of protein extraction, modification techniques, and cross-industry material adaptations

Obviousness Rationale

A PHOSITA would recognize that silk protein fragments with controlled molecular weight ranges represent a versatile platform technology with predictable modifications across multiple application domains. The source patent establishes foundational processing techniques for silk protein fragments, which inherently suggest potential adaptations for diverse industrial uses. The disclosed variations represent logical extensions of the core silk protein fragment technology, utilizing known molecular engineering principles to target specific industrial requirements.

Obvious Combinations & Variations

Source Patent Element
Lyophilized silk fibroin protein fragments with controlled molecular weight ranges (17-45 kDa)
PTD Variation
Applying silk protein fragments to 3D printing prosthetic limbs with modified molecular weight (6-16 kDa)
Obviousness Reasoning
Predictable material adaptation using known molecular weight tuning techniques to optimize biocompatibility for specific manufacturing processes
Source Patent Element
Reconstitutable silk protein fragment solutions without spontaneous gelation
PTD Variation
Creating bioactive medical device coatings using silk protein fragments
Obviousness Reasoning
Known technique of leveraging silk protein's inherent stability and biocompatibility for medical surface modifications
Source Patent Element
Silk protein fragments processable in various solvents
PTD Variation
Developing biodegradable packaging materials with specific molecular weight configurations
Obviousness Reasoning
Predictable material engineering approach using established protein fragment processing techniques to create sustainable alternatives
Source Patent Element
Silk protein fragments with controlled inorganic and organic residuals
PTD Variation
Agricultural film development with tailored silk protein fragment compositions
Obviousness Reasoning
Routine materials science approach of adapting protein fragment properties for environmental performance enhancement
Source Patent Element
Silk protein fragments with defined molecular weight distributions
PTD Variation
Personalized skincare product formulations using protein fragment compositions
Obviousness Reasoning
Obvious extension of material properties into cosmetic applications using standard protein engineering principles
35 U.S.C. § 103 Summary: Based on US Patent 11857663's teachings of silk protein fragment compositions, the present disclosure demonstrates that a Person Having Ordinary Skill In The Art would find the claimed variations obvious through routine materials engineering techniques. The disclosed adaptations represent predictable extensions of the foundational silk protein fragment technology, utilizing known molecular weight manipulation and processing strategies to address diverse industrial challenges.

Original Patent Information

Patent NumberUS 11,857,663
TitleStable silk protein fragment compositions
Assignee(s)EVOLVED BY NATURE, INC.