Silk-based Synergistic Systems

Publication ID: 24-11857663_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Silk-based Synergistic Systems,” Published Technical Disclosure No. 24-11857663_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857663_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,663.

Summary of the Inventive Concept

This inventive concept integrates silk protein fragment compositions with distinct technologies, such as AI, IoT, blockchain, and new materials, to create novel systems for personalized cosmetic products, quality monitoring, composite materials, biosensors, and biomedical implants.

Background and Problem Solved

The original patent disclosed stable silk protein fragment compositions with specific molecular weights. However, these compositions had limited applications. The new inventive concept addresses this limitation by combining the silk protein fragment compositions with other technologies to create more powerful systems, enhancing their functionality and expanding their potential uses.

Detailed Description of the Inventive Concept

The inventive concept comprises five synergistic systems: (1) a personalized cosmetic product system integrating silk protein fragments with AI-powered skin analysis and 3D printing; (2) a quality monitoring system combining IoT sensors with blockchain technology for tracking and verifying silk protein fragment quality; (3) a composite material system featuring a silk protein fragment matrix reinforced with graphene, nanocellulose, or carbon nanotubes; (4) a silk-based biosensor system integrating a silk protein fragment matrix with an embedded sensor module and AI-powered data analysis; and (5) a method for creating personalized biomedical implants using silk protein fragments, 3D printing, and AI-powered design optimization.

Novelty and Inventive Step

The new claims introduce novel combinations of silk protein fragment compositions with distinct technologies, resulting in unexpected synergies and improved functionalities. The inventive step lies in the integration of these technologies to create more powerful systems, which are not obvious from the original patent.

Alternative Embodiments and Variations

Alternative embodiments may include integrating silk protein fragments with other technologies, such as robotics, virtual reality, or advanced materials. Variations may involve using different types of protein fragments, modifying the silk protein fragment compositions, or adapting the systems for different industries or applications.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including cosmetics, biomedical devices, materials science, and quality control. The market for these systems is expected to grow rapidly, driven by increasing demand for personalized and high-performance products.

CPC Classifications

SectionClassGroup
A A61 A61K8/64
A A45 A45D33/00
A A61 A61K8/02
A A61 A61K8/0216
A A61 A61K8/042
A A61 A61K8/19
A A61 A61K8/27
A A61 A61K8/29
A A61 A61K8/365
A A61 A61K8/4953
A A61 A61K8/676
A A61 A61K8/735
A A61 A61K8/922
A A61 A61K8/97
A A61 A61K8/9789
A A61 A61K8/9794
A A61 A61K8/987
A A61 A61K9/08
A A61 A61K31/375
A A61 A61K38/00
A A61 A61K38/012
A A61 A61K45/06
A A61 A61K47/02
A A61 A61K47/12
A A61 A61K47/36
A A61 A61Q17/04
A A61 A61Q19/00
A A61 A61Q19/007
A A61 A61Q19/02
A A61 A61Q19/08
C C07 C07K1/12
C C07 C07K14/43586
A A61 A61K2800/591
A A61 A61K2800/72
A A61 A61K2800/74
A A61 A61K2800/75

Field of Art

Biomaterials and biotechnology, with expertise in protein engineering, materials science, and advanced manufacturing techniques involving silk protein compositions, spanning medical, cosmetic, and materials applications

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degrees in bioengineering, materials science, or chemical engineering, possessing knowledge of protein fragment manipulation, advanced manufacturing techniques, and interdisciplinary technology integration

Obviousness Rationale

A PHOSITA would recognize that the silk protein fragment composition from the source patent provides a versatile platform for technological integration, with predictable and expected outcomes when combined with emerging technologies like AI, IoT, and advanced materials processing techniques. The disclosed variations represent logical extensions of the base silk protein technology, utilizing well-established interdisciplinary engineering approaches to create novel systems with enhanced functionality.

Obvious Combinations & Variations

Source Patent Element
Lyophilized silk fibroin protein fragments with specific molecular weight ranges
PTD Variation
Integration of silk protein fragments with 3D printing and AI-powered design optimization for personalized cosmetic and biomedical applications
Obviousness Reasoning
Predictable application of known protein fragment characteristics to advanced manufacturing techniques, representing a standard design optimization approach in bioengineering
Source Patent Element
Silk protein fragment composition with controllable molecular properties
PTD Variation
Composite material system reinforcing silk protein matrix with graphene, nanocellulose, or carbon nanotubes
Obviousness Reasoning
Routine materials science approach of enhancing base material properties through well-understood reinforcement strategies, utilizing known composite material engineering principles
Source Patent Element
Silk protein fragments with specific molecular characteristics
PTD Variation
Biosensor system integrating silk protein matrix with embedded sensor modules and AI data analysis
Obviousness Reasoning
Conventional bioengineering technique of creating functional matrices by incorporating sensing technologies, representing a predictable technological extension
Source Patent Element
Lyophilized silk protein fragment composition with controlled residuals
PTD Variation
Quality monitoring system using IoT sensors and blockchain technology to track silk protein fragment production
Obviousness Reasoning
Standard industrial engineering approach to implementing tracking and verification systems for advanced material production processes
35 U.S.C. § 103 Summary: Based on US Patent 11857663's disclosure of silk protein fragment compositions, the present publication demonstrates that a person having ordinary skill in the art would find the claimed technological integrations obvious, as they represent predictable combinations of known techniques in bioengineering, materials science, and advanced manufacturing, thus rendering potential patent claims in these domains anticipated and non-patentable.

Original Patent Information

Patent NumberUS 11,857,663
TitleStable silk protein fragment compositions
Assignee(s)EVOLVED BY NATURE, INC.