Silk Protein Fragment Compositions for Niche Applications

Publication ID: 24-11857663_0009_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Silk Protein Fragment Compositions for Niche Applications,” Published Technical Disclosure No. 24-11857663_0009_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857663_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,663.

Summary of the Inventive Concept

Adapted silk protein fragment compositions for specific, narrow markets or unique operational environments, including high-security needs, disaster relief, and extreme weather conditions.

Background and Problem Solved

The original patent disclosed stable silk protein fragment compositions with specific molecular weights. However, these compositions were not tailored for specialized uses, such as high-security or disaster relief scenarios, which require unique properties and adaptations. The new inventive concept addresses this limitation by introducing silk protein fragment compositions adapted for niche applications.

Detailed Description of the Inventive Concept

The new inventive concept comprises silk protein fragment compositions with tailored molecular weights and properties for specific niche applications. For instance, compositions with molecular weights ranging from about 6 kDa to about 16 kDa are suited for disaster relief, while those with molecular weights ranging from about 17 kDa to about 38 kDa are adapted for high-security needs. The compositions can be formulated into portable containers, reconstituted solutions, or other forms suitable for their intended use. The new claims introduce specific adaptations for extreme weather conditions, high-stress environments, and high-security needs, ensuring the compositions remain stable and effective in these contexts.

Novelty and Inventive Step

The new claims introduce novel adaptations of the original silk protein fragment compositions, including tailored molecular weights, polydispersity ranges, and specific formulations for niche applications. These adaptations are non-obvious and provide unexpected benefits in their respective fields of use.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include silk protein fragment compositions adapted for other niche applications, such as medical emergency response or environmental remediation. Variations could also include different solvents, additives, or processing methods to further customize the compositions for their intended use.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including disaster relief, high-security, medical emergency response, and environmental remediation. The adapted silk protein fragment compositions could be marketed as specialized solutions for these niche markets, providing a competitive advantage over existing products.

CPC Classifications

SectionClassGroup
A A61 A61K8/64
A A45 A45D33/00
A A61 A61K8/02
A A61 A61K8/0216
A A61 A61K8/042
A A61 A61K8/19
A A61 A61K8/27
A A61 A61K8/29
A A61 A61K8/365
A A61 A61K8/4953
A A61 A61K8/676
A A61 A61K8/735
A A61 A61K8/922
A A61 A61K8/97
A A61 A61K8/9789
A A61 A61K8/9794
A A61 A61K8/987
A A61 A61K9/08
A A61 A61K31/375
A A61 A61K38/00
A A61 A61K38/012
A A61 A61K45/06
A A61 A61K47/02
A A61 A61K47/12
A A61 A61K47/36
A A61 A61Q17/04
A A61 A61Q19/00
A A61 A61Q19/007
A A61 A61Q19/02
A A61 A61Q19/08
C C07 C07K1/12
C C07 C07K14/43586
A A61 A61K2800/591
A A61 A61K2800/72
A A61 A61K2800/74
A A61 A61K2800/75

Field of Art

Biomaterials and protein engineering, with specific focus on silk protein compositions for medical, industrial, and specialized applications. Expertise requires advanced knowledge of protein chemistry, materials science, and molecular weight manipulation techniques

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degree in materials science, biochemistry, or bioengineering, capable of understanding protein fragment processing, molecular weight characterization, and application-specific material design

Obviousness Rationale

A person of ordinary skill would recognize that the source patent's silk protein fragment compositions provide a foundational framework for targeted molecular weight adaptations. The PTD's variations represent predictable extensions of known silk protein processing techniques, utilizing standard molecular weight manipulation methods within established ranges. The niche application focus represents a routine design optimization process for skilled practitioners familiar with material adaptation strategies.

Obvious Combinations & Variations

Source Patent Element
Lyophilized silk fibroin protein fragments with molecular weights between 17 kDa to 38 kDa
PTD Variation
Extending molecular weight range to 6-16 kDa for disaster relief applications
Obviousness Reasoning
Routine molecular weight adjustment using standard fractionation and processing techniques, representing a predictable variation within known protein fragment manipulation methods
Source Patent Element
Compositions substantially devoid of sericin
PTD Variation
Introducing polydispersity control between 1.5 to 3.0 for high-security and medical emergency applications
Obviousness Reasoning
Standard protein engineering technique to refine material properties, representing a known approach to improving compositional consistency
Source Patent Element
Reconstitutable silk protein fragment solutions
PTD Variation
Specialized formulations for extreme weather and high-stress environments
Obviousness Reasoning
Predictable application of existing protein processing knowledge to create environment-specific material adaptations
Source Patent Element
Water-based solvent systems for silk protein fragments
PTD Variation
Portable container systems for targeted delivery in disaster relief and medical emergency contexts
Obviousness Reasoning
Routine packaging and delivery method optimization using known protein preservation and transportation techniques
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed in this publication would have been obvious to a person having ordinary skill in the art at the time of invention, based on the teachings of US Patent 11857663. The claimed innovations represent predictable extensions of known silk protein fragment processing techniques, utilizing standard molecular weight manipulation, compositional refinement, and application-specific design strategies within the established technological framework of silk protein engineering.

Original Patent Information

Patent NumberUS 11,857,663
TitleStable silk protein fragment compositions
Assignee(s)EVOLVED BY NATURE, INC.