Silk-based Hybrid Systems for Advanced Materials and IoT Applications

Publication ID: 24-11857664_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Silk-based Hybrid Systems for Advanced Materials and IoT Applications,” Published Technical Disclosure No. 24-11857664_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857664_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,664.

Summary of the Inventive Concept

This inventive concept integrates stable silk protein fragment compositions with cutting-edge technologies such as AI, IoT, blockchain, and advanced materials to create novel systems with enhanced properties and functionalities.

Background and Problem Solved

The original patent disclosed stable silk protein fragment compositions with controlled molecular weights and polydispersities. However, these compositions had limited applications due to their standalone nature. This inventive concept addresses the need for integrating these compositions with other technologies to unlock their full potential and create more powerful systems.

Detailed Description of the Inventive Concept

The inventive concept comprises five synergistic combinations: 1) a system for generating customized silk-based products using machine learning algorithms, 2) a method for integrating silk protein fragments with IoT sensors, 3) a blockchain-based platform for tracking the provenance and quality of silk protein fragment compositions, 4) a composite material combining silk protein fragments with graphene-based nanomaterials, and 5) a system for 3D printing silk-based structures with customized properties. Each combination leverages the unique properties of silk protein fragments to create novel systems with enhanced mechanical strength, biocompatibility, and environmental responsiveness.

Novelty and Inventive Step

The new claims introduce novel and non-obvious combinations of silk protein fragment compositions with distinct technologies, resulting in systems that exhibit unexpected synergies and improved performance. The inventive step lies in the recognition of the potential for silk protein fragments to enhance and interact with these technologies in meaningful ways.

Alternative Embodiments and Variations

Alternative embodiments may include integrating silk protein fragments with other advanced materials, such as nanocellulose or metamaterials, or using different AI algorithms to optimize the composition selection process. Variations may also involve adapting the blockchain platform for tracking the provenance of other biomaterials or using the 3D printing system to create customized implants or medical devices.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including textiles, biomedical devices, and environmental monitoring. The silk-based hybrid systems can be used to create smart fabrics, implantable devices, and sustainable materials with enhanced properties, targeting a market projected to reach billions of dollars in the next decade.

CPC Classifications

SectionClassGroup
A A61 A61K8/64
A A45 A45D33/00
A A61 A61K8/02
A A61 A61K8/0216
A A61 A61K8/042
A A61 A61K8/19
A A61 A61K8/27
A A61 A61K8/29
A A61 A61K8/365
A A61 A61K8/4953
A A61 A61K8/676
A A61 A61K8/735
A A61 A61K8/922
A A61 A61K8/97
A A61 A61K8/9789
A A61 A61K8/9794
A A61 A61K8/987
A A61 A61K9/08
A A61 A61K31/375
A A61 A61K38/00
A A61 A61K38/012
A A61 A61K45/06
A A61 A61K47/02
A A61 A61K47/12
A A61 A61K47/36
A A61 A61Q17/04
A A61 A61Q19/00
A A61 A61Q19/007
A A61 A61Q19/02
A A61 A61Q19/08
C C07 C07K1/12
C C07 C07K14/43586
A A61 A61K2800/591
A A61 A61K2800/72
A A61 A61K2800/74
A A61 A61K2800/75

Field of Art

Biomaterials engineering, with a focus on protein-based materials, specifically silk protein fragment compositions for advanced technological applications. Requires expertise in materials science, biotechnology, nanotechnology, and interdisciplinary technology integration

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degrees in materials science, bioengineering, or related fields, possessing knowledge of protein engineering, materials characterization, and emerging technologies like IoT, AI, and advanced manufacturing techniques

Obviousness Rationale

A PHOSITA would recognize that the silk protein fragment compositions from the source patent provide a versatile platform for technological integration. The PTD's variations represent predictable extensions of the original silk protein technology, applying known interdisciplinary engineering techniques to enhance and expand the utility of silk protein fragments across multiple technological domains.

Obvious Combinations & Variations

Source Patent Element
Silk fibroin protein fragments with specific molecular weight ranges (17-38 kDa)
PTD Variation
Integrating these protein fragments with IoT sensors and machine learning algorithms for customized product generation
Obviousness Reasoning
A PHOSITA would find it obvious to apply machine learning to optimize material selection, as computational design techniques are well-established in materials engineering for selecting optimal compositional parameters
Source Patent Element
Silk protein fragments with variable crystalline and amorphous domain compositions
PTD Variation
Creating composite materials by combining silk protein fragments with graphene-based nanomaterials
Obviousness Reasoning
Combining biomaterials with nanomaterials is a known technique for enhancing mechanical and functional properties, representing a predictable materials engineering approach
Source Patent Element
Stable silk protein fragment compositions with defined structural characteristics
PTD Variation
Implementing a blockchain-based platform for tracking provenance and quality of silk protein compositions
Obviousness Reasoning
Tracking material provenance through blockchain is a standard approach in advanced materials engineering, representing an obvious method of ensuring material traceability and quality control
Source Patent Element
Silk protein fragments with tunable molecular properties
PTD Variation
3D printing silk-based structures with customized properties using computer-aided design
Obviousness Reasoning
Applying advanced manufacturing techniques like 3D printing to biomaterials is a predictable extension of materials engineering, particularly when the base material demonstrates adaptable structural characteristics
35 U.S.C. § 103 Summary: Based on US Patent 11857664 disclosing silk protein fragment compositions, the present publication demonstrates that a person having ordinary skill in the art would find the disclosed technological integrations obvious, as they represent predictable applications of known silk protein fragment technologies across interdisciplinary domains, thereby establishing prima facie obviousness under 35 U.S.C. ยง 103.

Original Patent Information

Patent NumberUS 11,857,664
TitleStable silk protein fragment compositions
Assignee(s)EVOLVED BY NATURE, INC.