Specialized Silk Protein Fragment Compositions for Niche Applications

Publication ID: 24-11857664_0004_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Specialized Silk Protein Fragment Compositions for Niche Applications,” Published Technical Disclosure No. 24-11857664_0004_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857664_0004_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,664.

Summary of the Inventive Concept

The inventive concept adapts stable silk protein fragment compositions for specific, narrow markets or unique operational environments, providing tailored solutions for high-security needs, disaster relief, extreme weather conditions, and more.

Background and Problem Solved

The original patent disclosed stable silk protein fragment compositions, but it did not address the limitations of these compositions in specialized contexts. The new inventive concept addresses these limitations by adapting the compositions for specific, high-stakes applications.

Detailed Description of the Inventive Concept

The new inventive concept comprises a range of silk protein fragment compositions tailored for niche applications. For example, a composition with a weight average molecular weight ranging from about 6 kDa to about 16 kDa and a polydispersity ranging from about 1.5 and about 3.0 is suitable for disaster relief in extreme weather conditions. A composition with a crystalline portion of about two-thirds and an amorphous region of about one-third can be used for high-security biometric identification. Other compositions are optimized for extreme cold temperatures, remote medical monitoring, and protecting sensitive electronics in high-humidity environments.

Novelty and Inventive Step

The new inventive concept's novelty lies in its adaptation of stable silk protein fragment compositions for specific, narrow markets or unique operational environments. The inventive step involves the selection of specific molecular weights, polydispersities, and crystalline-amorphous ratios to address the unique challenges of these applications.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include silk protein fragment compositions with different molecular weights, polydispersities, or crystalline-amorphous ratios tailored for other niche applications, such as space exploration or underwater operations.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including disaster relief, biometric identification, medical devices, and electronics. The target market includes government agencies, private companies, and non-profit organizations operating in high-stakes environments.

CPC Classifications

SectionClassGroup
A A61 A61K8/64
A A45 A45D33/00
A A61 A61K8/02
A A61 A61K8/0216
A A61 A61K8/042
A A61 A61K8/19
A A61 A61K8/27
A A61 A61K8/29
A A61 A61K8/365
A A61 A61K8/4953
A A61 A61K8/676
A A61 A61K8/735
A A61 A61K8/922
A A61 A61K8/97
A A61 A61K8/9789
A A61 A61K8/9794
A A61 A61K8/987
A A61 A61K9/08
A A61 A61K31/375
A A61 A61K38/00
A A61 A61K38/012
A A61 A61K45/06
A A61 A61K47/02
A A61 A61K47/12
A A61 A61K47/36
A A61 A61Q17/04
A A61 A61Q19/00
A A61 A61Q19/007
A A61 A61Q19/02
A A61 A61Q19/08
C C07 C07K1/12
C C07 C07K14/43586
A A61 A61K2800/591
A A61 A61K2800/72
A A61 A61K2800/74
A A61 A61K2800/75

Field of Art

Biomaterials and protein engineering, with a focus on silk protein compositions for medical, protective, and specialized applications. Requires expertise in polymer chemistry, materials science, and biotechnology

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degrees in materials science, biochemistry, or bioengineering, possessing knowledge of protein modification techniques, molecular weight manipulation, and material property optimization

Obviousness Rationale

A PHOSITA would recognize that the PTD's variations represent predictable modifications of the source patent's silk protein fragment compositions by systematically adjusting molecular weight, crystalline domain percentage, and application-specific targeting. The source patent establishes a foundational framework for silk protein fragment compositions, which a skilled practitioner would naturally extend to niche applications by making routine parameter adjustments. The disclosed variations demonstrate standard engineering problem-solving approaches within the established technological framework.

Obvious Combinations & Variations

Source Patent Element
Silk fibroin protein fragments with weight average molecular weight between 17 kDa to 38 kDa
PTD Variation
Modifying molecular weight range to 6 kDa to 16 kDa for disaster relief applications
Obviousness Reasoning
Predictable variation using known molecular weight adjustment techniques, representing a design choice for specific material properties
Source Patent Element
Compositions with crystalline protein domains ranging from 1.0% to 50.0%
PTD Variation
Selecting specific crystalline-amorphous ratios for biometric identification and electronics protection
Obviousness Reasoning
Routine optimization of material characteristics through known protein engineering methods, representing a finite set of predictable structural configurations
Source Patent Element
Substantially solid silk fibroin protein fragment compositions
PTD Variation
Targeting specific operational environments like extreme temperatures and high-humidity conditions
Obviousness Reasoning
Applying known material properties to novel application contexts using standard materials science problem-solving approaches
Source Patent Element
Silk fibroin protein fragments devoid of sericin
PTD Variation
Creating specialized compositions for remote medical monitoring and disaster relief
Obviousness Reasoning
Extending base composition through known protein purification and modification techniques to address specific functional requirements
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed in the Published Technical Disclosure render obvious any patent claims directed to silk protein fragment compositions with specific molecular weight ranges, crystalline domain percentages, or targeted applications, as substantiated by the foundational teachings of US Patent 11857664. A person having ordinary skill in the art would find the disclosed variations to represent predictable extensions of the prior art through routine engineering optimization and application-specific design choices.

Original Patent Information

Patent NumberUS 11,857,664
TitleStable silk protein fragment compositions
Assignee(s)EVOLVED BY NATURE, INC.