Silk Protein Fragment Compositions for Specialized Applications

Publication ID: 24-11857664_0009_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Silk Protein Fragment Compositions for Specialized Applications,” Published Technical Disclosure No. 24-11857664_0009_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857664_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,664.

Summary of the Inventive Concept

The present inventive concept relates to silk protein fragment compositions tailored for specific, narrow markets or unique operational environments, such as disaster relief, high-security needs, extreme weather conditions, and biodegradable packaging materials.

Background and Problem Solved

The original patent disclosed stable silk protein fragment compositions with varying crystalline protein domains and molecular weights. However, these compositions were not specifically designed for specialized applications, limiting their potential in addressing unique challenges. The present inventive concept addresses this limitation by adapting the silk protein fragment compositions for specific, high-value markets.

Detailed Description of the Inventive Concept

The inventive concept comprises silk protein fragments with tailored molecular weights and crystalline protein domains for distinct applications. For disaster relief, fragments with molecular weights ranging from about 6 kDa to about 16 kDa are used. For high-security biometric identification, fragments with molecular weights ranging from about 17 kDa to about 38 kDa are employed. In extreme weather conditions, fragments with polydispersity ranging from about 1.5 to about 3.0 are utilized. For high-temperature environments, fragments with molecular weights ranging from about 35 kDa to about 40 kDa are used. Lastly, for biodegradable packaging materials, fragments with molecular weights ranging from about 40 kDa to about 50 kDa are incorporated into a biodegradable matrix.

Novelty and Inventive Step

The present inventive concept's novelty lies in the adaptation of silk protein fragment compositions for specific, narrow markets or unique operational environments, which is non-obvious compared to the original patent. The inventive step involves the deliberate design of silk protein fragments with tailored properties to address the unique challenges of these specialized applications.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include silk protein fragment compositions for other specialized applications, such as medical implants, aerospace materials, or sustainable textiles. Variations could involve combining silk protein fragments with other biomaterials or incorporating them into composite structures.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in various industries, including disaster relief, biotechnology, security, and sustainable packaging. The target markets for these specialized silk protein fragment compositions are expected to be high-value and high-growth, driven by the increasing demand for tailored solutions in these areas.

CPC Classifications

SectionClassGroup
A A61 A61K8/64
A A45 A45D33/00
A A61 A61K8/02
A A61 A61K8/0216
A A61 A61K8/042
A A61 A61K8/19
A A61 A61K8/27
A A61 A61K8/29
A A61 A61K8/365
A A61 A61K8/4953
A A61 A61K8/676
A A61 A61K8/735
A A61 A61K8/922
A A61 A61K8/97
A A61 A61K8/9789
A A61 A61K8/9794
A A61 A61K8/987
A A61 A61K9/08
A A61 A61K31/375
A A61 A61K38/00
A A61 A61K38/012
A A61 A61K45/06
A A61 A61K47/02
A A61 A61K47/12
A A61 A61K47/36
A A61 A61Q17/04
A A61 A61Q19/00
A A61 A61Q19/007
A A61 A61Q19/02
A A61 A61Q19/08
C C07 C07K1/12
C C07 C07K14/43586
A A61 A61K2800/591
A A61 A61K2800/72
A A61 A61K2800/74
A A61 A61K2800/75

Field of Art

Biomaterials engineering, specifically protein fragment processing and modification for specialized applications, with expertise in silk protein manipulation, molecular weight characterization, and materials design across medical, packaging, and environmental domains

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with advanced degrees in materials science, bioengineering, or polymer chemistry, possessing knowledge of protein fragment processing techniques, molecular weight fractionation methods, and experience in designing protein-based materials for specific functional requirements

Obviousness Rationale

A person having ordinary skill in the art would recognize that the source patent's comprehensive disclosure of silk fibroin protein fragment compositions provides a foundational framework for targeted molecular weight and crystalline domain modifications. The PTD's specialized applications represent predictable extensions of known silk protein engineering principles, utilizing standard fractionation and molecular weight selection techniques. The variations demonstrate routine optimization of silk protein fragments for specific environmental and functional requirements within the established technological framework.

Obvious Combinations & Variations

Source Patent Element
Silk fibroin protein fragments with molecular weights between 17 kDa to 38 kDa
PTD Variation
Targeted molecular weight ranges for specific applications like high-security biometric identification
Obviousness Reasoning
Predictable result of routine molecular weight selection using standard protein fractionation techniques, representing a design choice within known processing parameters
Source Patent Element
Compositions with crystalline protein domains ranging from 1.0% to 50.0%
PTD Variation
Polydispersity modifications for extreme weather condition applications
Obviousness Reasoning
Obvious variation involving standard materials engineering techniques for adjusting protein fragment structural characteristics to enhance performance in specific environments
Source Patent Element
Substantially solid compositions of silk fibroin protein fragments devoid of sericin
PTD Variation
Application-specific fragment compositions for disaster relief, high-temperature environments, and biodegradable packaging
Obviousness Reasoning
Routine application of known silk protein fragment processing techniques to create targeted material compositions for specialized functional requirements
Source Patent Element
Molecular weight ranges between 35 kDa to 40 kDa
PTD Variation
High-temperature environment fragment compositions
Obviousness Reasoning
Predictable optimization of protein fragment characteristics through standard materials engineering approaches, representing a straightforward design modification
Source Patent Element
Silk fibroin protein fragment compositions with variable crystalline and amorphous regions
PTD Variation
Biodegradable matrix integration for packaging materials
Obviousness Reasoning
Obvious combination of known silk protein processing techniques with standard materials integration methods, representing a predictable technological extension
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed in the Published Technical Disclosure, when considered in light of US Patent 11857664, would have been obvious to a person having ordinary skill in the art at the time of the invention. The PTD demonstrates that the claimed variations represent routine optimization and predictable extensions of the foundational silk protein fragment processing techniques disclosed in the source patent, thereby rendering potential subsequent patent claims obvious and non-patentable.

Original Patent Information

Patent NumberUS 11,857,664
TitleStable silk protein fragment compositions
Assignee(s)EVOLVED BY NATURE, INC.