Copper-based Microbiome Modulation for Expanded Health Applications

Publication ID: 24-11857675_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Copper-based Microbiome Modulation for Expanded Health Applications,” Published Technical Disclosure No. 24-11857675_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857675_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,675.

Summary of the Inventive Concept

This inventive concept leverages the core technology of the original patent to develop novel applications for reducing the incidence and prevalence of various diseases and infections across multiple industries, including respiratory, neurodegenerative, skin, gastrointestinal, and cardiovascular health.

Background and Problem Solved

The original patent disclosed a method for reducing the incidence and prevalence of human papilloma virus (HPV) and providing protection against sexually transmitted infections. However, the patent's scope was limited to cervical cancer prevention. This inventive concept addresses the need for expanded applications of the core technology to tackle a broader range of diseases and infections, thereby increasing its potential impact on public health.

Detailed Description of the Inventive Concept

The inventive concept encompasses a family of devices and methods that utilize copper-based materials to modulate the microbiome in various parts of the body, such as the nasal cavity, oral cavity, skin, gut, and cardiovascular system. These devices and methods are designed to reduce inflammation, increase local immunity, and prevent the development of various diseases and infections. The copper-based materials are configured to have specific surface areas and geometries to optimize their interaction with the microbiome and achieve the desired therapeutic effects.

Novelty and Inventive Step

The new claims introduce novel applications of the core technology, including the use of copper-based devices for respiratory, neurodegenerative, skin, gastrointestinal, and cardiovascular health. These applications are non-obvious extensions of the original patent, as they require a deep understanding of the microbiome's role in various diseases and infections, as well as the development of specialized devices and methods tailored to each specific application.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different materials, such as silver or zinc, in place of copper. Additionally, the devices and methods could be adapted for use in veterinary medicine or agricultural applications. Furthermore, the inventive concept could be integrated with other therapeutic modalities, such as antimicrobial peptides or probiotics, to enhance its effectiveness.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including pharmaceuticals, medical devices, and consumer health products. The target market includes individuals and healthcare providers seeking to prevent or treat diseases and infections, as well as companies developing products and services related to microbiome modulation. The market size is substantial, with potential applications in multiple sectors and geographic regions.

CPC Classifications

SectionClassGroup
A A61 A61K9/0039
A A61 A61F6/144
A A61 A61K33/34

Field of Art

Medical device design and microbiome modification technologies, specifically focused on copper-based devices for therapeutic interventions in human health, with expertise in materials science, medical engineering, and microbial interaction mechanisms

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device researcher with advanced degrees, understanding of microbiome interactions, materials properties, and experience designing targeted therapeutic interventions across multiple physiological systems

Obviousness Rationale

A PHOSITA would recognize the fundamental principle of copper's microbiome-modulating properties established in the source patent and understand that these principles could be systematically extended to other bodily systems by applying consistent design parameters such as surface area, material composition, and localized placement strategies. The core technological insight of using copper to modify microbiome and enhance local immunity represents a generalizable approach that can be predictably adapted across different physiological contexts. The variations disclosed in the PTD represent logical extrapolations of the original patent's core technological concept, utilizing known design methodologies and established understanding of copper's antimicrobial properties.

Obvious Combinations & Variations

Source Patent Element
Uterine cervical device with specific copper surface area for modifying microbiome and reducing HPV infection
PTD Variation
Nasal device with copper surface area for reducing respiratory tract infections
Obviousness Reasoning
Predictable extension of known technique, applying identical design principles of surface area optimization and microbiome modulation to a different physiological system with similar immunological mechanisms
Source Patent Element
Method of maintaining device in position for 3-5 years to provide continuous microbiome intervention
PTD Variation
Copper-based wearable device for continuous skin microbiome modification
Obviousness Reasoning
Known design approach of sustained intervention through strategically placed copper-based medical device, representing a routine design choice for achieving consistent therapeutic effect
Source Patent Element
Copper device for reducing inflammatory response and increasing local immunity
PTD Variation
Oral device for modifying oral microbiome to reduce neurological inflammation
Obviousness Reasoning
Obvious combination of known copper interaction mechanisms with established understanding of microbiome's systemic inflammatory impacts, representing a logical technological progression
Source Patent Element
Manual insertion of uterine cervical device targeting specific microbiological interactions
PTD Variation
Ingestible capsule designed to modify gut microbiome through controlled copper interactions
Obviousness Reasoning
Routine engineering adaptation of device placement strategy, applying known principles of targeted microbiological intervention across different physiological systems
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857675, a person having ordinary skill in the art would find the variations disclosed in this publication to represent obvious extensions of the fundamental technological approach of using copper-based devices to modulate microbiome and enhance local immunity. The systematic application of the source patent's core principles across diverse physiological systems constitutes prior art that would render obvious any subsequently claimed innovations employing substantially similar methodological approaches.

Original Patent Information

Patent NumberUS 11,857,675
TitleMethod for reducing the incidence and prevalence of human papilloma virus (HPV) and for providing protection against sexually transmitted infections