Transdermal Pain Relief and Skin Irritation Treatment Compositions

Publication ID: 24-11857676_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Transdermal Pain Relief and Skin Irritation Treatment Compositions,” Published Technical Disclosure No. 24-11857676_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857676_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,676.

Summary of the Inventive Concept

This inventive concept leverages the core technology of the original patent to develop novel transdermal compositions for rapid pain relief and skin irritation treatment in various applications beyond oral pain relief.

Background and Problem Solved

The original patent addressed oral pain relief through dissolvable compositions. However, the same core technology can be adapted to address unmet needs in other areas, such as skin irritation, joint inflammation, sunburn, insect bites, and minor cuts and scrapes. Current treatments for these conditions often have limited efficacy, are slow-acting, or have undesirable side effects. The new inventive concept solves this problem by providing targeted, rapid, and effective pain relief and skin irritation treatment through transdermal delivery.

Detailed Description of the Inventive Concept

The new inventive concept involves the development of dissolvable carriers containing at least one active ingredient selected from guaiacol, eugenol, glycerin, menthol oil, peppermint oil, oregano oil, and cardamom oil. These carriers are designed to adhere to surfaces exhibiting skin irritation, joint inflammation, or other conditions, and dissolve over time to release the active ingredients. The compositions can be administered through various methods, including topical application, injection, or implantation, depending on the specific application. The active ingredients work synergistically to provide rapid pain relief, reduce inflammation, and promote healing.

Novelty and Inventive Step

The new inventive concept introduces a novel transdermal delivery mechanism for the original patent's active ingredients, expanding their application beyond oral pain relief. The inventive step lies in the adaptation of the core technology to address distinct problems in various fields, including dermatology, rheumatology, and wound care.

Alternative Embodiments and Variations

Alternative embodiments may include varying the composition's active ingredients, carrier materials, or delivery methods to suit specific applications. For example, the composition could be formulated as a spray, gel, or cream for topical application, or as a biodegradable implant for sustained release. Additionally, the inventive concept could be combined with other therapies, such as physical therapy or light therapy, to enhance its effectiveness.

Potential Commercial Applications and Market

The new inventive concept has significant commercial potential in various industries, including pharmaceuticals, cosmetics, and medical devices. Target markets include dermatology clinics, sports medicine centers, and wound care facilities. The compositions could be marketed as over-the-counter or prescription products, depending on the specific application and regulatory requirements.

CPC Classifications

SectionClassGroup
A A61 A61K9/006
A A61 A61K31/045
A A61 A61K31/047
A A61 A61K31/085
A A61 A61K36/53
A A61 A61K36/534
A A61 A61K36/9064
A A61 A61K47/10
A A61 A61K47/26
A A61 A61P23/02

Field of Art

Pharmaceutical and medical compositions, specifically transdermal drug delivery systems and topical pain relief formulations, involving organic compounds and herbal extracts for therapeutic applications

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced training in pharmaceutical sciences, organic chemistry, or biomedical engineering, possessing expertise in formulation design, drug delivery mechanisms, and understanding of active ingredient interactions

Obviousness Rationale

A PHOSITA would recognize that the source patent's specific oral pain relief composition represents a foundational technology that can be readily adapted to alternative delivery methods and therapeutic contexts. The active ingredient profile provides a clear template for exploring transdermal applications, with predictable pharmacological mechanisms that suggest broad utility beyond oral treatment. The disclosed variations represent logical extensions of the original compositional technology, utilizing known pharmaceutical engineering principles to expand the therapeutic potential of the established ingredient combination.

Obvious Combinations & Variations

Source Patent Element
Composition containing guaiacol, eugenol, glycerin, menthol, peppermint oil, oregano oil, and cardamom oil
PTD Variation
Transdermal delivery system using identical active ingredients for skin irritation and wound treatment
Obviousness Reasoning
Known pharmaceutical techniques enable straightforward adaptation of oral compositions to topical delivery, with predictable therapeutic results based on established pharmacological properties of ingredients
Source Patent Element
Active ingredients comprising 5-30% of total composition
PTD Variation
Adjusting concentration ranges for different transdermal application methods
Obviousness Reasoning
A PHOSITA would recognize concentration optimization as a routine design choice in pharmaceutical formulation, with finite predictable variations based on intended delivery mechanism
Source Patent Element
Dissolvable carrier with specific active ingredient ratios
PTD Variation
Alternative carrier materials and dissolution profiles for different therapeutic contexts
Obviousness Reasoning
Carrier material selection represents a standard engineering approach with multiple known techniques for modifying drug release characteristics
Source Patent Element
Oral pain relief composition
PTD Variation
Expanded applications including joint inflammation, sunburn, and wound treatment
Obviousness Reasoning
The broad therapeutic properties of the active ingredients suggest multiple predictable treatment modalities within related medical domains
Source Patent Element
Xylitol and aloe as carrier components
PTD Variation
Exploring alternative carrier materials with similar dissolution and absorption characteristics
Obviousness Reasoning
Pharmaceutical formulation involves routine experimentation with carrier materials, with a finite set of predictable substitutions based on known chemical properties
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857676, the disclosed transdermal compositions represent an obvious variation of the prior art, demonstrating that a person having ordinary skill in the art would readily recognize the potential for adapting the original oral pain relief formulation to alternative therapeutic delivery methods. The substantial overlap in active ingredients, predictable pharmacological mechanisms, and standard pharmaceutical engineering techniques render the claimed variations obvious and non-patentable under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,676
TitleCompositions for oral pain relief
Assignee(s)ORCA PRODUCTS, LLC