Melphalan-based Compositions for Novel Applications

Publication ID: 24-11857677_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Melphalan-based Compositions for Novel Applications,” Published Technical Disclosure No. 24-11857677_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857677_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,677.

Summary of the Inventive Concept

The inventive concept disclosed herein leverages the core technology of stable ready-to-use injectable formulations of melphalan to address unmet needs in diverse industries, including agriculture, timber preservation, medical devices, industrial wastewater treatment, and cosmetics.

Background and Problem Solved

The original patent addressed the challenge of stabilizing melphalan in liquid pharmaceutical formulations. However, its scope was limited to pharmaceutical applications. The new inventive concept expands the technology's reach to tackle distinct problems in various industries, such as fungal growth in agricultural soil, timber decay, microbial growth on medical devices, fungal contamination in industrial wastewater, and microbial spoilage in cosmetics.

Detailed Description of the Inventive Concept

The inventive concept involves the development of melphalan-based compositions tailored to specific industries. For instance, a melphalan-based composition for agricultural soil treatment would be formulated to effectively control fungal growth while ensuring soil and environmental safety. Similarly, a melphalan-based coating for medical devices would inhibit microbial growth on the device's surface. The composition for timber preservation would prevent fungal decay, while the industrial wastewater treatment composition would reduce fungal growth. Lastly, the melphalan-based preservative composition for cosmetics would inhibit microbial growth, thereby enhancing product shelf life.

Novelty and Inventive Step

The new inventive concept introduces novel applications and use cases for melphalan-based compositions, which were not envisioned in the original patent. The inventive step lies in the adaptation of the core technology to address distinct problems in diverse industries, thereby providing unexpected solutions and benefits.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include varying the concentration of melphalan, adjusting the composition's pH, or incorporating additional components to enhance efficacy or stability. Variations could also involve different methods of application, such as injection, spraying, or coating, depending on the specific industry and use case.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential across multiple industries. The agricultural sector could benefit from melphalan-based soil treatments, while the timber industry could reduce losses due to fungal decay. Medical device manufacturers could integrate melphalan-based coatings to enhance device safety, and industrial wastewater treatment plants could reduce fungal growth. Cosmetics manufacturers could extend product shelf life using melphalan-based preservatives. The market potential is substantial, with opportunities for partnerships, licensing, and new product development.

CPC Classifications

SectionClassGroup
A A61 A61K9/08
A A61 A61K9/0019
A A61 A61K31/198
A A61 A61K47/10
A A61 A61K47/183
A A61 A61K47/32

Original Patent Information

Patent NumberUS 11,857,677
TitleReady to use injectable formulations of melphalan and processes for preparation thereof
Assignee(s)RK PHARMA INC.