Melphalan-based solutions for diverse industries

Publication ID: 24-11857677_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Melphalan-based solutions for diverse industries,” Published Technical Disclosure No. 24-11857677_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857677_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,677.

Summary of the Inventive Concept

This inventive concept explores novel applications of melphalan, a bifunctional alkylating agent, in various industries beyond its traditional use in pharmaceuticals. The concept leverages the stability and effectiveness of melphalan-based formulations to address critical problems in agriculture, food preservation, fuel additives, pest control, and water treatment.

Background and Problem Solved

The original patent disclosed stable ready-to-use injectable formulations of melphalan for pharmaceutical applications. However, the limitations of this technology were confined to the medical field. This inventive concept addresses the need for innovative solutions in diverse industries, where the unique properties of melphalan can be harnessed to provide effective solutions.

Detailed Description of the Inventive Concept

The inventive concept involves the development of melphalan-based formulations tailored to specific industries. For instance, in agriculture, the formulation can be used to prevent or control fungal growth in crops. In food preservation, the formulation can be used to prevent spoilage of food products. Similarly, in fuel additives, the formulation can prevent corrosion of fuel tanks and lines. In pest control, the formulation can be used to prevent or control pest infestation in buildings. Finally, in water treatment, the formulation can prevent growth of algae and bacteria in water. These formulations can be administered through various means, such as injection, spraying, or mixing, depending on the specific application.

Novelty and Inventive Step

The novelty of this inventive concept lies in the unexpected application of melphalan-based formulations to diverse industries, beyond their traditional pharmaceutical use. The inventive step involves the recognition of the potential of melphalan to address critical problems in these industries and the development of tailored formulations to achieve this.

Alternative Embodiments and Variations

Alternative embodiments of this inventive concept may include the use of different solvents, excipients, or concentrations of melphalan to optimize the formulation for specific industries. Variations may also include the development of combination products, where melphalan is used in conjunction with other active ingredients to enhance its effectiveness.

Potential Commercial Applications and Market

The commercial potential of this inventive concept is vast, with potential applications in multiple industries. The market for melphalan-based solutions is expected to be significant, driven by the growing demand for innovative solutions in agriculture, food preservation, fuel additives, pest control, and water treatment. The target industries for these solutions include agricultural companies, food manufacturers, fuel suppliers, pest control services, and water treatment providers.

CPC Classifications

SectionClassGroup
A A61 A61K9/08
A A61 A61K9/0019
A A61 A61K31/198
A A61 A61K47/10
A A61 A61K47/183
A A61 A61K47/32

Field of Art

Pharmaceutical formulations and chemical compositions, with expertise in drug delivery systems, solvent interactions, and multi-industry chemical applications

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degree in chemistry or pharmaceutical sciences, understanding chemical stability, solvent interactions, and cross-industry applications of pharmaceutical compounds

Obviousness Rationale

A PHOSITA would recognize that the melphalan formulation's inherent chemical properties enable broad applications beyond pharmaceutical use. The source patent's teachings about melphalan's stability and solvent interactions provide a clear technical foundation for exploring alternative industrial uses. The disclosed variations represent predictable extensions of known chemical principles applied to different technical domains.

Obvious Combinations & Variations

Source Patent Element
Stable liquid parenteral formulation with 0.2-0.8 weight % melphalan and specific solvents
PTD Variation
Agricultural application for preventing fungal growth in crops using identical formulation parameters
Obviousness Reasoning
Known solvent system demonstrates compatibility with biological systems, making agricultural use a predictable design choice
Source Patent Element
Pharmaceutical formulation emphasizing chemical stability
PTD Variation
Food preservation and water treatment applications leveraging melphalan's antimicrobial properties
Obviousness Reasoning
Inherent chemical characteristics of melphalan suggest predictable antimicrobial effectiveness across different substrates
Source Patent Element
Injectable liquid formulation with defined concentration ranges
PTD Variation
Fuel additive and pest control applications using substantially identical chemical composition
Obviousness Reasoning
Transferring known pharmaceutical formulation parameters to industrial contexts represents standard engineering adaptation
Source Patent Element
Melphalan's chemical structure as a bifunctional alkylating agent
PTD Variation
Cross-industry applications exploiting fundamental molecular interaction capabilities
Obviousness Reasoning
A PHOSITA would recognize molecular properties enable predictable interactions across diverse chemical environments
Source Patent Element
Specific solvent combinations demonstrating chemical stability
PTD Variation
Alternative embodiments with modified solvent ratios for specific industrial requirements
Obviousness Reasoning
Routine experimentation with known solvent systems represents standard chemical engineering practice
35 U.S.C. § 103 Summary: Based on US Patent 11857677's comprehensive disclosure of melphalan formulation principles, the present publication demonstrates that the claimed industrial applications represent obvious variations apparent to a person having ordinary skill in pharmaceutical chemistry, rendering subsequent claims involving similar technical implementations anticipated and non-patentable.

Original Patent Information

Patent NumberUS 11,857,677
TitleReady to use injectable formulations of melphalan and processes for preparation thereof
Assignee(s)RK PHARMA INC.