Targeted Antibiotic Delivery Systems with Bioresponsive Nanoparticles
Legal Citation
Summary of the Inventive Concept
A next-generation antibiotic delivery system utilizing bioresponsive nanoparticles that adapt to local pH conditions, enabling targeted and efficient treatment of antibiotic-resistant infections.
Background and Problem Solved
The growing antibiotic resistance of harmful microbes has led to the development of novel drug delivery methods. The original patent disclosed an aqueous polyacrylate nanoparticle emulsion for water-solubilizing and encasing antibacterial compounds. However, these nanoparticles lack the ability to adapt to local conditions, reducing their efficacy. The new inventive concept addresses this limitation by incorporating bioresponsive polymers that respond to changes in pH levels, ensuring targeted antibiotic release.
Detailed Description of the Inventive Concept
The inventive concept comprises a system for targeted antibiotic delivery, featuring nanoparticles carrying antibiotics and a bioresponsive polymer matrix. The nanoparticles are designed to release antibiotics in response to changes in pH levels, allowing for precise and efficient treatment. Additionally, the system can be tailored to include photothermal agents, gene editing tools, or biofilm-disrupting enzymes to further enhance antibiotic efficacy and combat antibiotic resistance.
Novelty and Inventive Step
The new claims introduce a paradigm shift in antibiotic delivery by incorporating bioresponsive polymers, enabling targeted and adaptive release of antibiotics. This innovation provides a significant improvement over the original patent, which lacked the ability to respond to local conditions.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept may include the use of different bioresponsive polymers, varying nanoparticle sizes and shapes, or incorporating additional therapeutic agents. These variations can be tailored to address specific types of antibiotic-resistant infections or to optimize the system for different administration routes.
Potential Commercial Applications and Market
The targeted antibiotic delivery system has significant commercial potential in the pharmaceutical and healthcare industries, particularly in the treatment of antibiotic-resistant infections. The system's adaptability and precision make it an attractive solution for addressing the growing concern of antibiotic resistance, with potential applications in hospitals, clinics, and research institutions.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K9/1075 |
| A | A61 | A61K31/496 |
| A | A61 | A61K47/20 |
| A | A61 | A61K47/552 |
| A | A61 | A61K47/58 |
| A | A61 | A61K47/6907 |
| A | A61 | A61P31/04 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Pharmaceutical nanotechnology with a focus on drug delivery systems, specifically antibiotic encapsulation and targeted delivery mechanisms. Requires expertise in polymer chemistry, nanomaterials engineering, and pharmaceutical formulation techniques
Person of Ordinary Skill (PHOSITA) Profile
A researcher with advanced degrees in pharmaceutical sciences or chemical engineering, possessing knowledge of nanoparticle synthesis, polymer chemistry, drug delivery strategies, and experience with emulsion techniques and biomedical applications
Obviousness Rationale
A PHOSITA would recognize that the PTD's bioresponsive nanoparticle system represents a predictable extension of the source patent's aqueous polyacrylate nanoparticle technology. The core innovation involves adapting existing nanoparticle drug delivery principles to incorporate responsive polymer matrices and additional therapeutic mechanisms. These modifications represent standard design optimization strategies within the field of targeted drug delivery systems.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,679 |
|---|---|
| Title | Nanoparticles carrying antibiotics |
| Assignee(s) | University of South Florida |