Tailored Liposomal Compositions for Specialized Environments

Publication ID: 24-11857680_0004_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Tailored Liposomal Compositions for Specialized Environments,” Published Technical Disclosure No. 24-11857680_0004_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857680_0004_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,680.

Summary of the Inventive Concept

The present inventive concept discloses novel liposomal compositions of docetaxel tailored to address specific challenges in various niche environments, such as disaster relief, high-security needs, extreme weather conditions, and high-altitude environments.

Background and Problem Solved

The original patent invention relates to docetaxel liposomes for injection, which have limitations in terms of their applicability in unique operational environments. The present inventive concept addresses these limitations by adapting the liposomal composition to cater to specific needs, such as portability, tamper-evidence, weather-resistance, and pressure-resistance.

Detailed Description of the Inventive Concept

The inventive concept comprises five specialized variations of liposomal compositions, each tailored to address a specific challenge. The first variation is a portable liposomal composition for disaster relief areas, comprising a compact container and a simplified administration process. The second variation is a high-security liposomal composition, incorporating a tamper-evident excipient to prevent unauthorized access. The third variation is a system for administering docetaxel liposomes in extreme weather conditions, featuring a weather-resistant container and a temperature-controlled injector. The fourth variation is a liposomal composition for treating cancer in patients with compromised immune systems, comprising a high concentration of docetaxel and an immunoglobulin. The fifth variation is a liposomal composition for use in high-altitude environments, featuring a pressure-resistant excipient.

Novelty and Inventive Step

The novelty of the present inventive concept lies in the adaptation of the original liposomal composition to address specific challenges in various niche environments, resulting in a non-obvious and innovative solution. The inventive step is the identification of these specific challenges and the development of tailored solutions to overcome them.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include variations in the composition of the liposomes, such as using different solvents or excipients, or modifying the administration process to suit specific needs. Additionally, the inventive concept could be expanded to address other niche environments, such as space exploration or underwater operations.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in various industries, including pharmaceuticals, biotechnology, and healthcare. The target markets include disaster relief organizations, high-security facilities, and specialized medical centers operating in extreme environments.

CPC Classifications

SectionClassGroup
A A61 A61K9/127
A A61 A61K9/0019
A A61 A61K9/1277
A A61 A61K31/337
A A61 A61K47/24
A A61 A61K47/26
A A61 A61K47/28

Field of Art

Pharmaceutical Formulation and Drug Delivery Systems, specifically liposomal compositions for chemotherapeutic agents, involving expertise in pharmaceutical chemistry, drug encapsulation techniques, and specialized delivery mechanisms

Person of Ordinary Skill (PHOSITA) Profile

A pharmaceutical scientist or formulation engineer with advanced degree (PhD/MS) in pharmaceutical sciences, experienced in liposomal drug delivery, familiar with docetaxel formulation challenges, and skilled in modifying excipient compositions and delivery strategies

Obviousness Rationale

A PHOSITA would recognize that the PTD's variations represent predictable extensions of the source patent's core liposomal docetaxel technology, applying standard pharmaceutical engineering problem-solving techniques to address specific environmental and clinical challenges. The disclosed modifications leverage known formulation strategies and represent incremental adaptations that would be apparent to a skilled practitioner seeking to optimize drug delivery in specialized contexts.

Obvious Combinations & Variations

Source Patent Element
Docetaxel liposomal composition with specific weight percentages of components
PTD Variation
Modifying liposomal composition for disaster relief with portable container design
Obviousness Reasoning
Adapting container design is a routine design choice for a PHOSITA seeking to improve drug transportability, using known packaging engineering principles
Source Patent Element
Precise pH and particle size control in liposomal formulation
PTD Variation
Adding pressure-resistant excipients for high-altitude environments
Obviousness Reasoning
Modifying excipient composition to address environmental stress is a predictable solution using known pharmaceutical stabilization techniques
Source Patent Element
Docetaxel concentration and liposomal delivery mechanism
PTD Variation
Incorporating immunoglobulin for immunocompromised patients
Obviousness Reasoning
Enhancing therapeutic targeting through additional immunological components represents a standard approach in personalized drug delivery strategies
Source Patent Element
Precise weight percentages of phospholipids and stabilizing agents
PTD Variation
Adding tamper-evident excipients for high-security environments
Obviousness Reasoning
Introducing security-focused modifications using standard pharmaceutical excipient manipulation is an obvious design variation
Source Patent Element
Temperature and pH-stable liposomal docetaxel formulation
PTD Variation
Developing temperature-controlled injector for extreme weather conditions
Obviousness Reasoning
Creating specialized administration devices to maintain drug stability is a predictable engineering solution within pharmaceutical delivery systems
35 U.S.C. § 103 Summary: Based on US Patent 11857680's teachings, the present publication demonstrates that the claimed liposomal docetaxel variations represent obvious modifications to the prior art, employing standard pharmaceutical formulation techniques to address specific environmental and clinical challenges. A person of ordinary skill would recognize these adaptations as predictable extensions of known liposomal drug delivery principles, thereby rendering potential patent claims obvious and anticipatable.

Original Patent Information

Patent NumberUS 11,857,680
TitleComposition of docetaxel liposomal injection with high drug loading
Assignee(s)SHILPA MEDICARE LIMITED