Tailored Liposomal Compositions for Specialized Environments
Legal Citation
Summary of the Inventive Concept
The present inventive concept discloses novel liposomal compositions of docetaxel tailored to address specific challenges in various niche environments, such as disaster relief, high-security needs, extreme weather conditions, and high-altitude environments.
Background and Problem Solved
The original patent invention relates to docetaxel liposomes for injection, which have limitations in terms of their applicability in unique operational environments. The present inventive concept addresses these limitations by adapting the liposomal composition to cater to specific needs, such as portability, tamper-evidence, weather-resistance, and pressure-resistance.
Detailed Description of the Inventive Concept
The inventive concept comprises five specialized variations of liposomal compositions, each tailored to address a specific challenge. The first variation is a portable liposomal composition for disaster relief areas, comprising a compact container and a simplified administration process. The second variation is a high-security liposomal composition, incorporating a tamper-evident excipient to prevent unauthorized access. The third variation is a system for administering docetaxel liposomes in extreme weather conditions, featuring a weather-resistant container and a temperature-controlled injector. The fourth variation is a liposomal composition for treating cancer in patients with compromised immune systems, comprising a high concentration of docetaxel and an immunoglobulin. The fifth variation is a liposomal composition for use in high-altitude environments, featuring a pressure-resistant excipient.
Novelty and Inventive Step
The novelty of the present inventive concept lies in the adaptation of the original liposomal composition to address specific challenges in various niche environments, resulting in a non-obvious and innovative solution. The inventive step is the identification of these specific challenges and the development of tailored solutions to overcome them.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include variations in the composition of the liposomes, such as using different solvents or excipients, or modifying the administration process to suit specific needs. Additionally, the inventive concept could be expanded to address other niche environments, such as space exploration or underwater operations.
Potential Commercial Applications and Market
The present inventive concept has significant commercial potential in various industries, including pharmaceuticals, biotechnology, and healthcare. The target markets include disaster relief organizations, high-security facilities, and specialized medical centers operating in extreme environments.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K9/127 |
| A | A61 | A61K9/0019 |
| A | A61 | A61K9/1277 |
| A | A61 | A61K31/337 |
| A | A61 | A61K47/24 |
| A | A61 | A61K47/26 |
| A | A61 | A61K47/28 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Pharmaceutical Formulation and Drug Delivery Systems, specifically liposomal compositions for chemotherapeutic agents, involving expertise in pharmaceutical chemistry, drug encapsulation techniques, and specialized delivery mechanisms
Person of Ordinary Skill (PHOSITA) Profile
A pharmaceutical scientist or formulation engineer with advanced degree (PhD/MS) in pharmaceutical sciences, experienced in liposomal drug delivery, familiar with docetaxel formulation challenges, and skilled in modifying excipient compositions and delivery strategies
Obviousness Rationale
A PHOSITA would recognize that the PTD's variations represent predictable extensions of the source patent's core liposomal docetaxel technology, applying standard pharmaceutical engineering problem-solving techniques to address specific environmental and clinical challenges. The disclosed modifications leverage known formulation strategies and represent incremental adaptations that would be apparent to a skilled practitioner seeking to optimize drug delivery in specialized contexts.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,680 |
|---|---|
| Title | Composition of docetaxel liposomal injection with high drug loading |
| Assignee(s) | SHILPA MEDICARE LIMITED |