RNA-Lipid Technology for Novel Applications

Publication ID: 24-11857681_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “RNA-Lipid Technology for Novel Applications,” Published Technical Disclosure No. 24-11857681_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857681_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,681.

Summary of the Inventive Concept

This inventive concept leverages RNA-lipid technology to address pressing problems in personalized nutrition, food waste reduction, air quality monitoring, sustainable agriculture, and bioremediation, demonstrating the versatility of this core technology in new industries and use cases.

Background and Problem Solved

The original patent focused on non-viral delivery of RNA for immunization. However, the limitations of this approach lie in its restricted application to the field of immunization. This inventive concept solves the problem of limited scope by applying the RNA-lipid technology to entirely new fields, tackling critical issues in various industries.

Detailed Description of the Inventive Concept

The inventive concept comprises RNA molecules encoding specific guidance, indicators, sensors, enhancers, or enzymes, which are then delivered using lipid particles tailored for each application. For personalized nutrition, RNA molecules are synthesized based on a user's genetic profile and dietary needs. In food waste reduction, RNA molecules encode spoilage indicators, and lipid-based sensors detect spoilage. For air quality monitoring, RNA molecules encode air quality sensors, and lipid particles enhance detection sensitivity. In sustainable agriculture, RNA molecules encode crop yield enhancers, and lipid particles target plant roots. Finally, in bioremediation, RNA molecules encode pollution-degrading enzymes, and lipid-based sensors detect degradation.

Novelty and Inventive Step

The novelty of this inventive concept lies in the unexpected application of RNA-lipid technology to new industries and use cases, which is non-obvious compared to the original patent's focus on immunization. The inventive step involves the design and synthesis of RNA molecules and lipid particles tailored for each specific application, demonstrating a significant departure from the original patent's scope.

Alternative Embodiments and Variations

Alternative embodiments include using different types of lipid particles, modifying the RNA molecules to target specific cell types, or integrating the RNA-lipid technology with other sensing or detection methods. Variations could include applying the technology to other industries, such as cosmetics or pharmaceuticals, or developing new RNA-lipid formulations for specific applications.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential in various industries, including personalized health and wellness, food technology, environmental monitoring, sustainable agriculture, and bioremediation. The market for these applications is vast, with potential customers ranging from individual consumers to large corporations and government agencies.

CPC Classifications

SectionClassGroup
A A61 A61K9/127
A A61 A61K9/1272
A A61 A61K31/7088
A A61 A61K39/00
A A61 A61K39/12
C C12 C12N15/86
A A61 A61K39/39
A A61 A61K2039/53
A A61 A61K2039/55555
C C12 C12N2710/16134
C C12 C12N2760/18534
C C12 C12N2770/36134

Original Patent Information

Patent NumberUS 11,857,681
TitleLipid formulations with RNA encoding immunogens
Assignee(s)GlaxoSmith Kline Biologicals S.A.