Microorganism Control and Remediation using Phenobarbital-based Compositions

Publication ID: 24-11857683_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Microorganism Control and Remediation using Phenobarbital-based Compositions,” Published Technical Disclosure No. 24-11857683_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857683_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,683.

Summary of the Inventive Concept

The present inventive concept discloses novel applications of phenobarbital-based compositions in agricultural, environmental, and veterinary fields, leveraging the stabilization technology developed for pharmaceutical purposes.

Background and Problem Solved

The original patent addressed the stabilization of phenobarbital sodium for injection, but its scope was limited to pharmaceutical applications. However, the problem of microorganism growth and fungal infections persists in various industries, including agriculture, bioremediation, and veterinary medicine. The present inventive concept tackles these issues by adapting the core technology to create novel compositions and methods for controlling and remediating microorganisms.

Detailed Description of the Inventive Concept

The inventive concept comprises a system for monitoring and controlling microorganism growth in agricultural environments, a method for improving crop yields by reducing fungal infections, a bioremediation system for degrading pollutants in contaminated soil, a veterinary composition for treating fungal infections in animals, and a method for preserving food products by inhibiting microorganism growth. These applications utilize lyophilized compositions of phenobarbital or salts thereof, with an ethanol content in the range from about 5000 ppm to about 70000 ppm, to provide effective and targeted solutions.

Novelty and Inventive Step

The new claims introduce an inventive step by applying the stabilization technology to entirely new fields, addressing unmet needs in microorganism control and remediation. The novelty lies in the unexpected application of phenobarbital-based compositions in agricultural, environmental, and veterinary contexts, which was not contemplated in the original patent.

Alternative Embodiments and Variations

Alternative embodiments may include varying the ethanol content, using different salts of phenobarbital, or incorporating additional active ingredients to enhance the composition's efficacy. Variations may also involve adapting the composition for specific microorganisms or industries, such as using the technology to control algae growth in aquatic environments or to treat fungal infections in companion animals.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the agricultural, environmental, and veterinary industries, with potential applications in crop protection, bioremediation, animal health, and food preservation. The market for microorganism control and remediation solutions is substantial, and the present inventive concept offers a unique and effective solution to address these needs.

CPC Classifications

SectionClassGroup
A A61 A61K9/19
A A61 A61K9/08
A A61 A61K31/515
A A61 A61K47/10
A A61 A61P25/08

Field of Art

Pharmaceutical and agricultural biotechnology, with expertise in drug formulation, stabilization techniques, and microorganism control systems. Practitioners would have advanced degrees in chemistry, pharmacology, or microbiology with specialized knowledge in drug delivery and composition modification

Person of Ordinary Skill (PHOSITA) Profile

A skilled researcher with understanding of pharmaceutical stabilization techniques, knowledge of ethanol's role in chemical compositions, and ability to adapt pharmaceutical technologies to adjacent technical domains such as agriculture and environmental remediation

Obviousness Rationale

The PTD represents a predictable extension of the source patent's stabilization technology by applying the established lyophilized phenobarbital composition to novel application domains. A PHOSITA would recognize that the core stabilization mechanism involving controlled ethanol content could be readily translated across different technical fields. The fundamental chemical principles underlying the source patent's pharmaceutical approach are directly transferable to agricultural and environmental microorganism control contexts.

Obvious Combinations & Variations

Source Patent Element
Lyophilized pharmaceutical composition with specific ethanol content range (5000-70000 ppm)
PTD Variation
Application of same composition to agricultural microorganism control systems
Obviousness Reasoning
Known technique of adapting pharmaceutical stabilization methods to agricultural contexts, with predictable results in microorganism management
Source Patent Element
Phenobarbital sodium salt formulation with controlled impurities
PTD Variation
Veterinary and environmental remediation compositions using similar salt formulations
Obviousness Reasoning
Finite set of known salt modifications with expected performance characteristics across related technical domains
Source Patent Element
Stabilization method focusing on ethanol content and impurity management
PTD Variation
Extension to food preservation and bioremediation applications
Obviousness Reasoning
Predictable application of established chemical stabilization principles to adjacent technical problem domains
Source Patent Element
Pharmaceutical composition for treating neonatal conditions
PTD Variation
Fungal infection treatment in animals and crops
Obviousness Reasoning
Known strategy of repurposing pharmaceutical compounds for related biological intervention scenarios
Source Patent Element
Controlled ethanol content in lyophilized composition
PTD Variation
Microorganism growth inhibition across different environmental contexts
Obviousness Reasoning
Obvious technical adaptation using well-understood chemical interaction principles
35 U.S.C. § 103 Summary: Based on US Patent 11857683, the present publication demonstrates that a person having ordinary skill in the art would find the disclosed agricultural, environmental, and veterinary applications of phenobarbital-based compositions obvious and predictable extensions of existing pharmaceutical stabilization technologies, thereby rendering subsequent claims in these domains anticipated and non-patentable under standard obviousness criteria.

Original Patent Information

Patent NumberUS 11,857,683
TitleStabilization of phenobarbital sodium for injection
Assignee(s)SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED