Published Technical Disclosure Archive

Phenobarbital Sodium Stabilization for Agricultural, Veterinary, and Food Processing Applications

Publication ID: 24-11857683_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Phenobarbital Sodium Stabilization for Agricultural, Veterinary, and Food Processing Applications,” Published Technical Disclosure No. 24-11857683_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857683_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,683.

Summary of the Inventive Concept

The present inventive concept expands the core technology of stabilizing phenobarbital sodium for injection to novel applications in agricultural, veterinary, and food processing industries, enabling improved product shelf-life, efficacy, and safety.

Background and Problem Solved

The original patent disclosed a lyophilized pharmaceutical composition of phenobarbital sodium for injection, addressing the problem of hydrolytic instability. However, the limitations of the original patent did not consider the potential of this technology in other industries. The present inventive concept solves the problem of degradation and instability of phenobarbital sodium in these new applications.

Detailed Description of the Inventive Concept

The inventive concept comprises a system for monitoring and controlling the stabilization of phenobarbital sodium in agricultural applications, a method for enhancing the shelf-life of phenobarbital sodium-based pesticides, a composition for use in veterinary medicine, a system for detecting and preventing the degradation of phenobarbital sodium in food processing, and a method for treating fungal infections in plants. These new applications leverage the core technology of stabilizing phenobarbital sodium with a controlled ethanol content to achieve improved product performance and safety.

Novelty and Inventive Step

The inventive concept introduces a novel and non-obvious application of the original patent's technology to entirely different industries, addressing specific problems and needs in agricultural, veterinary, and food processing. The inventive step lies in the recognition of the potential for this technology to be adapted and optimized for these new use cases.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include variations in the ethanol content range, different sensor and controller configurations, and modifications to the lyophilization process. These variations can be tailored to specific industry requirements and product formulations.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the agricultural, veterinary, and food processing industries, where the stabilization of phenobarbital sodium can improve product shelf-life, efficacy, and safety. The target market includes manufacturers of pesticides, veterinary medicines, and food processing companies, as well as farmers and agricultural professionals.

CPC Classifications

SectionClassGroup
A A61 A61K9/19
A A61 A61K9/08
A A61 A61K31/515
A A61 A61K47/10
A A61 A61P25/08

Field of Art

Pharmaceutical formulation and stabilization, with expertise in lyophilization techniques, drug composition design, and pharmaceutical processing across medical, veterinary, and agricultural applications

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degree in pharmaceutical sciences, understanding of chemical stabilization methods, experience in drug formulation, and knowledge of ethanol-based stabilization techniques for pharmaceutical compounds

Obviousness Rationale

A PHOSITA would recognize that the core stabilization technology of phenobarbital sodium can be readily adapted across different industrial domains by applying the established ethanol content range and lyophilization principles. The fundamental chemical stabilization mechanism disclosed in the source patent provides a predictable template for extending the technology to agricultural, veterinary, and food processing applications. The variations represent logical extensions of the original patent's core technological insights, utilizing known pharmaceutical engineering techniques to solve domain-specific preservation challenges.

Obvious Combinations & Variations

Source Patent Element
Lyophilized pharmaceutical composition with 12000-50000 ppm ethanol content
PTD Variation
Applying the same ethanol stabilization technique to pesticide formulations
Obviousness Reasoning
Predictable result of extending known stabilization method to related chemical preservation contexts, representing a routine design adaptation
Source Patent Element
Method for controlling total impurities below 0.2% during storage
PTD Variation
Implementing impurity detection systems in food processing and veterinary applications
Obviousness Reasoning
Known quality control technique that would be obvious to apply across different pharmaceutical and biological domains
Source Patent Element
Phenobarbital sodium as primary compound
PTD Variation
Expanding application from medical treatment to agricultural fungal infection control
Obviousness Reasoning
Predictable exploration of compound's potential uses within known pharmacological and agricultural domains
Source Patent Element
Lyophilization process with specific ethanol content range
PTD Variation
Modifying lyophilization parameters for veterinary and agricultural product requirements
Obviousness Reasoning
Routine engineering adaptation using known pharmaceutical processing techniques
Source Patent Element
Sensor and controller for monitoring composition stability
PTD Variation
Implementing monitoring systems across different industrial application contexts
Obviousness Reasoning
Obvious technological transfer of stabilization monitoring techniques across related technical domains
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857683, a person having ordinary skill in pharmaceutical formulation would find the variations disclosed herein obvious, as they represent predictable extensions of known lyophilization and chemical stabilization techniques. The proposed applications in agricultural, veterinary, and food processing domains constitute obvious variations that would be readily conceived by a skilled practitioner without requiring inventive insight beyond the scope of the original patent's technological disclosure.

Original Patent Information

Patent NumberUS 11,857,683
TitleStabilization of phenobarbital sodium for injection
Assignee(s)SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED