Collagenase-based Therapies for Diverse Tissue Applications
Legal Citation
Summary of the Inventive Concept
This inventive concept leverages the core technology of collagenase-based treatments for uterine fibroids to address various tissue-related disorders in different industries, including dermatology, wound care, and aesthetics.
Background and Problem Solved
The original patent focused on treating uterine fibroids using collagenase, but its core technology has broader implications. The new inventive concept tackles the limitations of the original patent by applying collagenase to novel applications, including skin lesions, scar tissue, keloid scars, acne, and wrinkles.
Detailed Description of the Inventive Concept
The new claims describe systems, methods, and compositions for treating diverse tissue-related disorders using collagenase. For instance, a topical application of collagenase can reduce the viscoelastic properties of skin lesion tissue, while administering collagenase to scar tissue breaks down collagen fibers. The inventive concept also encompasses delivery vehicles, such as sonic wave devices, to enhance penetration and efficacy. These novel applications capitalize on the unique properties of collagenase to address unmet needs in various industries.
Novelty and Inventive Step
The new claims introduce non-obvious and novel applications of collagenase-based treatments, expanding beyond the original patent's focus on uterine fibroids. The inventive step lies in recognizing the potential of collagenase to address tissue-related disorders in diverse fields and developing specific systems, methods, and compositions to achieve this.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include using different collagenase concentrations, delivery methods, or combination therapies to target specific tissue disorders. Variations may also involve adapting the technology for veterinary applications or exploring synergies with other therapeutic agents.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in various industries, including dermatology, wound care, and aesthetics. The market for collagenase-based treatments is substantial, with potential applications in treating skin lesions, scars, acne, and wrinkles, as well as addressing unmet needs in veterinary medicine.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K9/48 |
| A | A61 | A61K9/0019 |
| A | A61 | A61K9/0034 |
| A | A61 | A61K9/1075 |
| A | A61 | A61K38/43 |
| A | A61 | A61K38/4886 |
| A | A61 | A61K45/06 |
| C | C12 | C12Y304/24003 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Medical biotechnology focused on enzymatic tissue modification, specifically collagenase-based therapeutic interventions across dermatological and soft tissue applications
Person of Ordinary Skill (PHOSITA) Profile
A biomedical researcher or clinical scientist with expertise in enzyme biochemistry, tissue engineering, and medical device development, possessing advanced knowledge of collagenase properties and therapeutic applications
Obviousness Rationale
A PHOSITA would recognize that the fundamental mechanism of collagenase in breaking down collagen fibers is universally applicable across different tissue types, making the extension from uterine fibroid treatment to other soft tissue modifications a predictable and logical progression of the core technological concept.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,685 |
|---|---|
| Title | Treatment method and product for uterine fibroids using purified collagenase |
| Assignee(s) | Duke University, BioSpecifics Technologies LLC |