Collagenase-based Therapies for Diverse Tissue Applications

Publication ID: 24-11857685_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Collagenase-based Therapies for Diverse Tissue Applications,” Published Technical Disclosure No. 24-11857685_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857685_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,685.

Summary of the Inventive Concept

This inventive concept leverages the core technology of collagenase-based treatments for uterine fibroids to address various tissue-related disorders in different industries, including dermatology, wound care, and aesthetics.

Background and Problem Solved

The original patent focused on treating uterine fibroids using collagenase, but its core technology has broader implications. The new inventive concept tackles the limitations of the original patent by applying collagenase to novel applications, including skin lesions, scar tissue, keloid scars, acne, and wrinkles.

Detailed Description of the Inventive Concept

The new claims describe systems, methods, and compositions for treating diverse tissue-related disorders using collagenase. For instance, a topical application of collagenase can reduce the viscoelastic properties of skin lesion tissue, while administering collagenase to scar tissue breaks down collagen fibers. The inventive concept also encompasses delivery vehicles, such as sonic wave devices, to enhance penetration and efficacy. These novel applications capitalize on the unique properties of collagenase to address unmet needs in various industries.

Novelty and Inventive Step

The new claims introduce non-obvious and novel applications of collagenase-based treatments, expanding beyond the original patent's focus on uterine fibroids. The inventive step lies in recognizing the potential of collagenase to address tissue-related disorders in diverse fields and developing specific systems, methods, and compositions to achieve this.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include using different collagenase concentrations, delivery methods, or combination therapies to target specific tissue disorders. Variations may also involve adapting the technology for veterinary applications or exploring synergies with other therapeutic agents.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including dermatology, wound care, and aesthetics. The market for collagenase-based treatments is substantial, with potential applications in treating skin lesions, scars, acne, and wrinkles, as well as addressing unmet needs in veterinary medicine.

CPC Classifications

SectionClassGroup
A A61 A61K9/48
A A61 A61K9/0019
A A61 A61K9/0034
A A61 A61K9/1075
A A61 A61K38/43
A A61 A61K38/4886
A A61 A61K45/06
C C12 C12Y304/24003

Original Patent Information

Patent NumberUS 11,857,685
TitleTreatment method and product for uterine fibroids using purified collagenase
Assignee(s)Duke University, BioSpecifics Technologies LLC