Synergistic Uterine Fibroid Treatment System

Publication ID: 24-11857685_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Uterine Fibroid Treatment System,” Published Technical Disclosure No. 24-11857685_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857685_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,685.

Summary of the Inventive Concept

A novel, integrated system combining collagenase-based treatment with AI, IoT, blockchain, and advanced materials to revolutionize uterine fibroid treatment, enhancing efficacy, personalization, and patient data management.

Background and Problem Solved

The original patent disclosed a method for treating uterine fibroids using purified collagenase. However, this treatment approach has limitations, such as lack of real-time visualization, limited patient data management, and restricted delivery methods. The new inventive concept addresses these limitations by integrating distinct technologies to create a more powerful, comprehensive system.

Detailed Description of the Inventive Concept

The Synergistic Uterine Fibroid Treatment System comprises several interconnected modules. The collagenase composition delivery module administers the purified collagenase to the uterine fibroid. The AI-powered imaging module provides real-time fibroid visualization, enabling precise treatment monitoring. The blockchain-based patient data management system securely stores and analyzes patient data, ensuring confidentiality and facilitating personalized treatment planning. IoT-enabled sensors track fibroid size reduction, and machine learning algorithms analyze treatment outcomes. The system also incorporates biocompatible, 3D-printed matrices for targeted delivery and nanocarrier systems for enhanced bioavailability. Genetic testing and machine learning-based treatment planning modules enable personalized treatment approaches.

Novelty and Inventive Step

The new claims introduce a synergistic combination of technologies, creating a novel system that overcomes the limitations of the original patent. The integration of AI, IoT, blockchain, and advanced materials with collagenase-based treatment represents a non-obvious, innovative step in uterine fibroid treatment.

Alternative Embodiments and Variations

Alternative embodiments may include variations in the AI-powered imaging module, such as using different imaging modalities or incorporating additional sensors. The blockchain-based patient data management system could be replaced with alternative secure data storage solutions. The collagenase composition delivery module could be modified to accommodate different delivery methods or matrices.

Potential Commercial Applications and Market

The Synergistic Uterine Fibroid Treatment System has significant commercial potential in the medical device and pharmaceutical industries, addressing a high-incidence, high-burden disease affecting millions of women worldwide. The system's personalized approach, enhanced efficacy, and improved patient data management capabilities position it for market success.

CPC Classifications

SectionClassGroup
A A61 A61K9/48
A A61 A61K9/0019
A A61 A61K9/0034
A A61 A61K9/1075
A A61 A61K38/43
A A61 A61K38/4886
A A61 A61K45/06
C C12 C12Y304/24003

Field of Art

Medical biotechnology, specifically interventional treatment of uterine fibroids, involving pharmaceutical composition design, targeted drug delivery, and medical imaging technologies

Person of Ordinary Skill (PHOSITA) Profile

A medical researcher or biotechnology engineer with expertise in interventional medicine, enzyme-based treatments, medical device design, and advanced diagnostic technologies, holding advanced degrees in biomedical engineering, biotechnology, or related fields

Obviousness Rationale

A PHOSITA would recognize that integrating digital technologies with established medical treatment methodologies represents a natural progression of medical innovation. The combination of collagenase-based treatment with AI, IoT, and data management technologies follows predictable patterns of technological convergence in personalized medicine. The disclosed variations leverage known techniques in medical technology to enhance treatment precision, monitoring, and patient outcomes.

Obvious Combinations & Variations

Source Patent Element
Collagenase composition for uterine fibroid treatment with specific concentration ranges
PTD Variation
Adding biocompatible 3D-printed matrices and nanocarrier systems for targeted collagenase delivery
Obviousness Reasoning
Known drug delivery enhancement techniques applied to existing treatment methodology, representing a predictable optimization of pharmaceutical composition
Source Patent Element
Needle-based delivery method for collagenase composition
PTD Variation
IoT-enabled sensors for real-time tracking of fibroid size reduction and treatment efficacy
Obviousness Reasoning
Integrating monitoring technologies with existing medical procedures is a standard approach in modern interventional medicine, representing an obvious technological extension
Source Patent Element
Treatment method targeting uterine fibroids
PTD Variation
AI-powered imaging and machine learning-based predictive analytics for personalized treatment planning
Obviousness Reasoning
Applying machine learning and advanced imaging to medical treatment represents a known technique for improving diagnostic and therapeutic precision
Source Patent Element
Composition comprising collagenase from Clostridium histolyticum
PTD Variation
Blockchain-based patient data management system for secure treatment tracking and personalization
Obviousness Reasoning
Implementing secure data management technologies in medical contexts is a predictable technological evolution with well-understood implementation strategies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857685 and the disclosed technological variations, a person having ordinary skill in the art would find the claimed innovations obvious and lacking non-obvious inventive merit. The systematic integration of digital technologies with established medical treatment methodologies represents a predictable technological progression that would be apparent to a skilled practitioner in the field of interventional medical technologies.

Original Patent Information

Patent NumberUS 11,857,685
TitleTreatment method and product for uterine fibroids using purified collagenase
Assignee(s)Duke University, BioSpecifics Technologies LLC