Synergistic Uterine Fibroid Treatment System

Publication ID: 24-11857685_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Uterine Fibroid Treatment System,” Published Technical Disclosure No. 24-11857685_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857685_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,685.

Summary of the Inventive Concept

A novel, integrated system combining collagenase-based treatment with AI, IoT, blockchain, and advanced materials to revolutionize uterine fibroid treatment, enhancing efficacy, personalization, and patient data management.

Background and Problem Solved

The original patent disclosed a method for treating uterine fibroids using purified collagenase. However, this treatment approach has limitations, such as lack of real-time visualization, limited patient data management, and restricted delivery methods. The new inventive concept addresses these limitations by integrating distinct technologies to create a more powerful, comprehensive system.

Detailed Description of the Inventive Concept

The Synergistic Uterine Fibroid Treatment System comprises several interconnected modules. The collagenase composition delivery module administers the purified collagenase to the uterine fibroid. The AI-powered imaging module provides real-time fibroid visualization, enabling precise treatment monitoring. The blockchain-based patient data management system securely stores and analyzes patient data, ensuring confidentiality and facilitating personalized treatment planning. IoT-enabled sensors track fibroid size reduction, and machine learning algorithms analyze treatment outcomes. The system also incorporates biocompatible, 3D-printed matrices for targeted delivery and nanocarrier systems for enhanced bioavailability. Genetic testing and machine learning-based treatment planning modules enable personalized treatment approaches.

Novelty and Inventive Step

The new claims introduce a synergistic combination of technologies, creating a novel system that overcomes the limitations of the original patent. The integration of AI, IoT, blockchain, and advanced materials with collagenase-based treatment represents a non-obvious, innovative step in uterine fibroid treatment.

Alternative Embodiments and Variations

Alternative embodiments may include variations in the AI-powered imaging module, such as using different imaging modalities or incorporating additional sensors. The blockchain-based patient data management system could be replaced with alternative secure data storage solutions. The collagenase composition delivery module could be modified to accommodate different delivery methods or matrices.

Potential Commercial Applications and Market

The Synergistic Uterine Fibroid Treatment System has significant commercial potential in the medical device and pharmaceutical industries, addressing a high-incidence, high-burden disease affecting millions of women worldwide. The system's personalized approach, enhanced efficacy, and improved patient data management capabilities position it for market success.

CPC Classifications

SectionClassGroup
A A61 A61K9/48
A A61 A61K9/0019
A A61 A61K9/0034
A A61 A61K9/1075
A A61 A61K38/43
A A61 A61K38/4886
A A61 A61K45/06
C C12 C12Y304/24003

Original Patent Information

Patent NumberUS 11,857,685
TitleTreatment method and product for uterine fibroids using purified collagenase
Assignee(s)Duke University, BioSpecifics Technologies LLC