Collagenase-based Solutions for Industrial and Environmental Applications
Legal Citation
Summary of the Inventive Concept
The inventive concept leverages the core technology of collagenase-based treatment for uterine fibroids to address unmet needs in various industries, including paper production, textile manufacturing, soil erosion prevention, industrial equipment maintenance, and biofuel generation.
Background and Problem Solved
The original patent disclosed a method for treating uterine fibroids using purified collagenase. However, the potential applications of collagenase extend far beyond medical treatments. This inventive concept addresses the limitations of the original patent by exploring new use cases for collagenase in industrial and environmental contexts, where its unique properties can provide significant benefits.
Detailed Description of the Inventive Concept
The new claims describe various systems, methods, and compositions that utilize collagenase to break down and recycle cellulose fibers in waste paper, degrade and recycle keratin-based materials, stabilize soil particles, remove stubborn deposits of collagen-rich substances, and convert collagen-rich biomass into fermentable sugars. These applications take advantage of collagenase's ability to selectively degrade collagen-rich materials, offering a sustainable and efficient solution for various industries.
Novelty and Inventive Step
The new claims introduce a novel and non-obvious application of collagenase-based technology, departing from the original patent's medical focus. The inventive step lies in recognizing the potential of collagenase to address specific challenges in industrial and environmental contexts, and developing tailored solutions to capitalize on this potential.
Alternative Embodiments and Variations
Alternative embodiments may include using different sources of collagenase, such as bacterial or fungal-derived enzymes, or combining collagenase with other enzymes or agents to enhance its effectiveness. Variations may also involve adapting the collagenase-based solutions for use in other industries, such as wastewater treatment or bioremediation.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in various industries, including paper and pulp, textiles, construction, and bioenergy. The market for collagenase-based solutions is expected to grow as companies seek sustainable and efficient solutions to reduce waste, increase productivity, and promote environmental stewardship.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K9/48 |
| A | A61 | A61K9/0019 |
| A | A61 | A61K9/0034 |
| A | A61 | A61K9/1075 |
| A | A61 | A61K38/43 |
| A | A61 | A61K38/4886 |
| A | A61 | A61K45/06 |
| C | C12 | C12Y304/24003 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biotechnology and enzyme engineering, with expertise in protein biochemistry, industrial enzyme applications, and collagenase-based biotransformation technologies
Person of Ordinary Skill (PHOSITA) Profile
A professional with advanced degree in biochemistry or biotechnology, familiar with enzyme characterization, industrial biotechnology applications, and cross-industry enzyme adaptation strategies
Obviousness Rationale
A skilled practitioner would recognize the fundamental enzymatic properties of collagenase from the source patent and understand its potential for broader applications beyond medical treatments. The core mechanism of collagen degradation is transferable across multiple technical domains, making the industrial and environmental variations predictable extensions of the original enzymatic technology. The PTD demonstrates systematic adaptation of a known enzymatic process to solve diverse technical challenges through routine engineering and application design.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,685 |
|---|---|
| Title | Treatment method and product for uterine fibroids using purified collagenase |
| Assignee(s) | Duke University, BioSpecifics Technologies LLC |