Enhanced Medical Sealant Glue for Improved Wound Healing
Legal Citation
Summary of the Inventive Concept
The present invention relates to an improved medical sealant glue capable of promoting wound healing with enhanced gelation time, swelling ratio, mechanical properties, and bioactive peptide incorporation, thereby providing a more efficient and effective wound healing process.
Background and Problem Solved
The original patent disclosed a medical sealant glue capable of promoting wound healing. However, the original glue had limitations in terms of gelation time, swelling ratio, and mechanical properties, which hindered its widespread adoption. The present invention addresses these limitations by introducing improvements to the glue's formulation and preparation method.
Detailed Description of the Inventive Concept
The enhanced medical sealant glue comprises a crosslinked compound of a first component containing nucleophilic functional groups and a second component containing electrophilic functional groups. The glue is formulated to have improved gelation time, reduced by at least 30% compared to the original glue. Additionally, the glue is designed to have an increased swelling ratio in PBS solution, promoting wound healing. The glue may also incorporate a bioactive peptide to further enhance the wound healing process. The preparation method of the glue is optimized to reduce the gelation time and improve the swelling ratio of the resulting glue.
Novelty and Inventive Step
The present invention provides a novel and non-obvious solution to the limitations of the original medical sealant glue. The improvements in gelation time, swelling ratio, and mechanical properties, as well as the incorporation of bioactive peptides, provide a significant advancement in the field of wound healing.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept may include varying the type and concentration of the bioactive peptide, using different biocompatible fibers to reinforce the glue, or modifying the preparation method to achieve optimal gelation time and swelling ratio.
Potential Commercial Applications and Market
The enhanced medical sealant glue has significant commercial potential in the wound care industry, particularly in the treatment of chronic wounds, surgical wounds, and burns. The glue's improved properties make it an attractive solution for healthcare providers seeking to accelerate wound healing and reduce healthcare costs.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61L24/043 |
| A | A61 | A61K35/28 |
| A | A61 | A61L24/0005 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biomedical materials and wound healing technologies, specifically medical sealant compositions with a focus on crosslinked polymeric systems and regenerative medicine approaches
Person of Ordinary Skill (PHOSITA) Profile
A biomedical engineer or materials scientist with expertise in polymer chemistry, wound healing technologies, and medical device development, holding at least a Master's degree with 3-5 years of specialized experience in biomaterial design and medical adhesive formulations
Obviousness Rationale
A person of ordinary skill would recognize that the PTD's modifications to the medical sealant glue represent predictable variations within the established technological framework of the source patent. The disclosed improvements in gelation time, swelling ratio, and incorporation of bioactive peptides are logical extensions of known techniques in wound healing materials. These modifications would be considered routine optimization and design choices for a skilled practitioner seeking to enhance medical sealant performance.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,693 |
|---|---|
| Title | Medical sealant glue capable of promoting wound healing and preparation method thereof |
| Assignee(s) | Shandong Branden Medical Device Co.,Ltd |