Enhanced Bone Graft System with Optimized Porosity and Bioactivity

An improved bone graft system featuring a silicate-based material with optimized porosity, metal cation distribution, and phosphate content for enhanced bone growth, integration, and regeneration.

The original bone graft system patent (PCT/GB2016/052221) had limitations in terms of its density, pore size, and metal cation distribution, which affected its bioactivity and bone regeneration capabilities. The new inventive concept addresses these limitations by introducing optimized porosity, uniform metal cation distribution, and tailored phosphate content, resulting in a more efficient and effective bone graft system.

The enhanced bone graft system consists of a silicate-based material with a porous structure, wherein the density is less than 0.7 g/cm3 and the average pore size is optimized for improved bone growth and integration. The silicate network is formed using a combination of calcium nitrate tetrahydrate and triethyl phosphate, resulting in improved mechanical strength and biocompatibility. The metal cations are distributed uniformly throughout the network, enhancing bioactivity and promoting bone regeneration. The phosphate content is optimized for enhanced bone growth and mineralization, and the material is fabricated using a CPD method to preserve its porous structure. The system can be customized to specific patient needs by varying the metal cation content, phosphate content, and pore size, resulting in improved treatment outcomes.

The new inventive concept introduces a novel combination of optimized porosity, uniform metal cation distribution, and tailored phosphate content, which provides a significant improvement over the original patent. The use of a CPD method to preserve the porous structure and the customization options for specific patient needs are also novel and non-obvious features.

Alternative embodiments of the inventive concept could include the use of different silicate-based materials, varying the metal cation type and content, or incorporating additional bioactive molecules into the silicate network. The system could also be adapted for use in other medical applications, such as wound healing or tissue engineering.

The enhanced bone graft system has significant commercial potential in the dental and orthopedic implant markets, where there is a growing demand for more effective and efficient bone graft substitutes. The customization options and improved treatment outcomes could also lead to increased adoption in personalized medicine and regenerative therapies.