Enhanced Bone Graft System with Improved Bioactivity and Mechanical Strength
Legal Citation
Summary of the Inventive Concept
The present invention relates to an improved bone graft system, which enhances bioactivity and mechanical strength by incorporating surface coatings, hierarchical porous structures, and controlled release of bioactive molecules.
Background and Problem Solved
The original bone graft system patent has limitations in terms of bioactivity and mechanical strength. The present invention addresses these limitations by introducing novel features that improve the bone graft substitutes' performance in dental or orthopaedic implants.
Detailed Description of the Inventive Concept
The enhanced bone graft system comprises a silicate-based material with a porous structure, incorporating metal cations and having a density less than 0.7 g/cm3. The system further includes a surface coating to enhance bioactivity and cellular adhesion, a hierarchical porous structure with macroporous framework and microporous channels to enhance cellular infiltration and tissue regeneration, and a controlled release mechanism for bioactive molecules to promote tissue regeneration. The system can be customized by adjusting the mechanical properties through mechanical treatment.
Novelty and Inventive Step
The new claims introduce novel features such as surface coatings, hierarchical porous structures, and controlled release of bioactive molecules, which are not present in the original patent. These features provide an inventive step by improving the bioactivity and mechanical strength of the bone graft substitutes.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include using different types of surface coatings, varying the hierarchical porous structure's dimensions, or incorporating additional bioactive molecules. These variations would ensure broad conceptual coverage and adaptability to different implant applications.
Potential Commercial Applications and Market
The enhanced bone graft system has significant commercial potential in the dental and orthopaedic implant markets, where there is a growing demand for improved bone graft substitutes. The system's improved bioactivity and mechanical strength could lead to increased adoption and market share.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61L27/40 |
| A | A61 | A61L27/425 |
| A | A61 | A61L27/427 |
| A | A61 | A61L27/52 |
| A | A61 | A61L27/56 |
| A | A61 | A61L2430/02 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biomaterials and orthopedic implant engineering, specifically bone graft substitutes with focus on silicate-based materials for medical applications. Requires expertise in materials science, biomaterial design, surface modification, and tissue engineering techniques
Person of Ordinary Skill (PHOSITA) Profile
A biomedical engineer or materials scientist with advanced degree, working knowledge of silicate network structures, experience in bone substitute design, understanding of material modification techniques, and familiarity with tissue regeneration principles
Obviousness Rationale
A PHOSITA would recognize that the PTD's variations represent predictable engineering improvements to the foundational silicate-based bone graft system disclosed in the source patent. The proposed modifications of surface coatings, hierarchical porosity, and controlled molecule release are logical extensions of known biomaterial design principles. These variations would be considered routine optimization techniques within the skill set of an ordinary practitioner in biomaterials engineering.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,698 |
|---|---|
| Title | Bone graft system |
| Assignee(s) | UCL BUSINESS LTD |