Next-Generation Blood Solute Monitoring and Adaptive Dialysis System

Publication ID: 24-11857712_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Next-Generation Blood Solute Monitoring and Adaptive Dialysis System,” Published Technical Disclosure No. 24-11857712_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857712_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,712.

Summary of the Inventive Concept

A wearable, real-time blood solute monitoring system integrated with AI-driven adaptive dialysis therapy, enabling personalized and optimized treatment outcomes.

Background and Problem Solved

The original patent relates to systems and methods for utilizing a sorbent cartridge and quantifying chemistry changes to determine solute concentrations in dialysate. However, these systems have limitations in terms of real-time monitoring, adaptability, and precision. The new inventive concept addresses these limitations by introducing a wearable, miniaturized dialysate recirculation module, nanoscale sorbent cartridge, and machine learning-based analytics engine, enabling real-time monitoring and adaptive dialysis therapy.

Detailed Description of the Inventive Concept

The next-generation blood solute monitoring and adaptive dialysis system consists of a wearable, miniaturized dialysate recirculation module, a nanoscale sorbent cartridge integrated with a microfluidic sensor array, and a machine learning-based analytics engine. The system continuously monitors blood solute levels using the wearable module, dynamically adjusts dialysate composition and flow rates based on real-time analytics, and optimizes treatment outcomes using a cloud-based, AI-driven decision support system. The system also features an artificial intelligence-powered, autonomous sorbent cartridge management module, which predicts and prevents cartridge exhaustion, optimizes reagent usage, and ensures seamless treatment continuity.

Novelty and Inventive Step

The new inventive concept introduces a paradigm shift in dialysis therapy by integrating wearable, real-time monitoring with AI-driven adaptive therapy, enabling personalized and optimized treatment outcomes. The use of nanoscale sorbent cartridges, microfluidic sensor arrays, and machine learning-based analytics engines represents a significant departure from the original patent's limitations, providing a novel and non-obvious solution.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include implantable, wireless-enabled sensors, graphene-based electrochemical sensor arrays, or cloud-based analytics platforms. Variations of the system may also incorporate genomic and proteomic data integration, precision treatment planning, or iterative, real-time feedback mechanisms.

Potential Commercial Applications and Market

The next-generation blood solute monitoring and adaptive dialysis system has significant commercial potential in the dialysis therapy market, with potential applications in hospitals, clinics, and home care settings. The system's ability to provide personalized and optimized treatment outcomes, reduce treatment costs, and improve patient quality of life makes it an attractive solution for healthcare providers and patients alike.

CPC Classifications

SectionClassGroup
A A61 A61M1/1696
A A61 A61M1/14
A A61 A61M1/165
A A61 A61M1/1605
A A61 A61M1/1609
A A61 A61M1/1613
A A61 A61M1/1619
A A61 A61M1/1694
A A61 A61M1/28
A A61 A61M1/3406
A A61 A61M1/3472
A A61 A61M1/3486
A A61 A61M2202/0498
A A61 A61M2205/05
A A61 A61M2205/3317
A A61 A61M2205/3324
A A61 A61M2205/3334
B B01 B01D15/08
B B01 B01D15/362

Original Patent Information

Patent NumberUS 11,857,712
TitleRecirculating dialysate fluid circuit for measurement of blood solute species
Assignee(s)MOZARC MEDICAL US LLC