Next-Generation Biological Fluid Processing Systems

Publication ID: 24-11857714_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Next-Generation Biological Fluid Processing Systems,” Published Technical Disclosure No. 24-11857714_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857714_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,714.

Summary of the Inventive Concept

A paradigm shift in biological fluid processing, integrating machine learning, wearable technology, and real-time analytics to revolutionize fluid balance monitoring and control.

Background and Problem Solved

The original patent disclosed systems and methods for monitoring and controlling fluid balance in medical procedures, but limitations in real-time data analysis and treatment personalization hindered its potential. The new inventive concept addresses these limitations by introducing advanced technologies to provide more accurate, personalized, and efficient fluid balance management.

Detailed Description of the Inventive Concept

The next-generation biological fluid processing system comprises a machine learning module to predict optimal fluid volumes based on patient medical history and treatment data. A wearable, portable light source for extracorporeal photopheresis enables real-time monitoring and treatment. A nanofiltration module removes unwanted cellular components, and a microfluidic channel analyzes fluid composition in real-time. The system integrates with a database of genomic profiles to predict optimal treatment protocols and provide real-time feedback. In vivo monitoring of fluid balance is achieved through implantable micro-sensors, transmitting data to a remote server for analysis and feedback.

Novelty and Inventive Step

The new inventive concept's integration of machine learning, wearable technology, and real-time analytics provides a novel and non-obvious solution for biological fluid processing, surpassing the original patent's limitations and enabling more accurate, personalized, and efficient fluid balance management.

Alternative Embodiments and Variations

Alternative embodiments may include using different machine learning algorithms, varying the type of wearable technology, or incorporating additional sensors for in vivo monitoring. Variations may also include adapting the system for use in different medical procedures or integrating with other medical devices.

Potential Commercial Applications and Market

The next-generation biological fluid processing system has significant commercial potential in the medical device industry, particularly in the fields of hematology, oncology, and personalized medicine. The system's ability to provide real-time, personalized fluid balance management can improve treatment outcomes, reduce healthcare costs, and enhance patient quality of life.

CPC Classifications

SectionClassGroup
A A61 A61M1/3607
A A61 A61M1/0209
A A61 A61M1/361
A A61 A61M1/3643
A A61 A61M1/3672
A A61 A61M1/3683
A A61 A61M1/3693
A A61 A61M1/3696
A A61 A61M1/38
A A61 A61M2202/0092
A A61 A61M2202/0407
A A61 A61M2202/0413
A A61 A61M2202/0415
A A61 A61M2202/0429
A A61 A61M2202/0439
A A61 A61M2202/0443
A A61 A61M2205/3386
A A61 A61M2205/50
A A61 A61M2230/005
A A61 A61M2230/207

Field of Art

Medical fluid processing technologies, specifically blood separation and treatment systems, involving complex medical device engineering, fluid dynamics, and biomedical instrumentation with expertise in centrifugation, pump systems, and cellular processing techniques

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device specialist with advanced degree, working knowledge of fluid processing technologies, understanding of medical device control systems, machine learning applications in medical contexts, and familiarity with emerging sensor and monitoring technologies

Obviousness Rationale

A PHOSITA would recognize that the PTD's machine learning and real-time monitoring extensions represent predictable technological improvements to the source patent's fluid processing framework. The core fluid separation and control mechanisms remain fundamentally consistent, with the PTD introducing incremental enhancements in data analysis, personalization, and monitoring capabilities. These variations represent natural technological progressions enabled by advances in computational and sensor technologies.

Obvious Combinations & Variations

Source Patent Element
Biological fluid processing device with separation chamber and pump system for controlling fluid volumes
PTD Variation
Machine learning module predicting optimal fluid volumes and providing real-time feedback based on patient data
Obviousness Reasoning
Integrating predictive analytics with existing fluid control systems is a known technique in medical device engineering, representing a predictable application of machine learning to improve treatment precision
Source Patent Element
Centrifuge-based separation component for processing whole blood
PTD Variation
Nanofiltration module and microfluidic channel for cellular component removal and real-time composition analysis
Obviousness Reasoning
Advancing cellular separation techniques through more granular filtration and analysis represents an obvious technological progression for a PHOSITA seeking improved processing accuracy
Source Patent Element
Single access device for pumping whole blood into separation chamber
PTD Variation
Wearable, portable light source for extracorporeal photopheresis with integrated sensor and rechargeable battery
Obviousness Reasoning
Miniaturizing and enhancing medical processing equipment with integrated sensing capabilities is a predictable design evolution in medical device technology
Source Patent Element
Fluid circuit with separation and treatment containers
PTD Variation
Genomic profile database integrated with biological fluid processing device for personalized treatment protocols
Obviousness Reasoning
Leveraging patient-specific data to customize medical procedures is a known approach in precision medicine, representing an obvious extension of existing fluid processing technologies
Source Patent Element
Controller for actuating pump systems and separation components
PTD Variation
Implantable micro-sensors for continuous in vivo fluid balance monitoring with remote data transmission
Obviousness Reasoning
Extending device control and monitoring capabilities through miniaturized, networked sensors is a predictable technological progression in medical monitoring systems
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857714 and the published technical disclosure, a person having ordinary skill in the art would find the claimed variations obvious, as they represent predictable technological improvements utilizing known techniques in machine learning, sensor integration, and personalized medical processing. The disclosed variations extend the source patent's fluid processing framework through incremental enhancements that would be apparent to a skilled practitioner in the field of medical device engineering.

Original Patent Information

Patent NumberUS 11,857,714
TitleSystems and methods for monitoring and controlling fluid balance during a biological fluid procedure
Assignee(s)Fenwal, Inc.