Microdose Delivery Systems for Diverse Therapeutic Applications

Publication ID: 24-11857757_0007_PTD
Published: November 07, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Microdose Delivery Systems for Diverse Therapeutic Applications,” Published Technical Disclosure No. 24-11857757_0007_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857757_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,757.

Summary of the Inventive Concept

The inventive concept expands the core technology of wearable patch pumps to deliver microdoses of medication, cosmetic agents, pain-relieving medication, vitamins, and hormones for various therapeutic applications, addressing unmet needs in diverse industries.

Background and Problem Solved

The original patent disclosed wearable insulin pumps for Type I Diabetes Mellitus patients. However, these devices are limited to insulin delivery and do not address the needs of patients requiring microdoses of other medications or agents. The inventive concept solves this problem by adapting the core technology to cater to a broader range of therapeutic applications.

Detailed Description of the Inventive Concept

The inventive concept comprises wearable patch pumps configured to deliver microdoses of medication, cosmetic agents, pain-relieving medication, vitamins, and hormones. The system includes a controller that adjusts the dosage based on the user's specific needs, skin type, condition, or desired outcome. The wearable device can be removably adhered to the user's skin and may include sensors to detect the user's pain levels, skin type, or other relevant parameters. The inventive concept enables precise, personalized, and targeted delivery of microdoses, offering improved efficacy and reduced side effects.

Novelty and Inventive Step

The new claims introduce the concept of adapting wearable patch pumps for diverse therapeutic applications beyond insulin delivery. The inventive step lies in the recognition that the core technology can be modified to address unmet needs in various industries, such as skin care, pain management, and fertility treatment.

Alternative Embodiments and Variations

Alternative embodiments may include wearable devices with interchangeable cartridges for different medications or agents, or devices with integrated sensors for real-time monitoring of the user's condition. Variations may also include devices with different form factors, such as wristbands or adhesive strips, or devices that utilize different delivery mechanisms, such as iontophoresis or electroporation.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including pharmaceuticals, cosmetics, pain management, and fertility treatment. The market for wearable patch pumps is expected to grow substantially as the technology is adapted for diverse therapeutic applications, offering improved patient outcomes and reduced healthcare costs.

CPC Classifications

SectionClassGroup
A A61 A61M5/14248
A A61 A61B5/14865
A A61 A61M5/1413
A A61 A61M5/158
A A61 A61M5/168
A A61 A61M5/1684
A A61 A61M5/16827
A A61 A61M5/172
A A61 A61M5/1723
A A61 A61M5/5086
A A61 A61M2005/14252
A A61 A61M2005/14256
A A61 A61M2005/14533
A A61 A61M2005/1586
A A61 A61M2205/18
A A61 A61M2205/3317
A A61 A61M2205/3331
A A61 A61M2205/582
A A61 A61M2207/00

Field of Art

Medical device engineering, specifically wearable drug delivery systems, focusing on microdosing technologies for transdermal medication administration across multiple therapeutic domains

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer with expertise in microfluidics, drug delivery systems, and wearable medical technologies, possessing knowledge of patch pump designs, sensor integration, and personalized medication delivery mechanisms

Obviousness Rationale

A PHOSITA would recognize that the core technological architecture of the insulin patch pump can be systematically adapted to deliver diverse medications by modifying cartridge contents, adjusting dosage control algorithms, and integrating domain-specific sensors. The fundamental mechanical and electronic principles of the source patent's microdosing system are directly transferable across therapeutic applications with predictable modifications. The variations represent routine engineering adaptations within a well-established technological framework of transdermal drug delivery systems.

Obvious Combinations & Variations

Source Patent Element
Patch pump configured for removable skin adhesion with transcutaneous medication delivery
PTD Variation
Expanding patch pump design to deliver cosmetic agents, pain medications, vitamins, and hormones
Obviousness Reasoning
Predictable variation using known transdermal delivery techniques, with cartridge composition being a straightforward design choice for a PHOSITA
Source Patent Element
Controller for managing medication dosage based on device state
PTD Variation
Adaptive dosage control based on user-specific parameters like skin type, pain levels, and physiological conditions
Obviousness Reasoning
Known technique of implementing context-aware dosing algorithms, representing a logical extension of existing control system design principles
Source Patent Element
Integrated sensor systems for monitoring device and medication delivery parameters
PTD Variation
Adding specialized sensors for detecting skin conditions, pain levels, and physiological markers
Obviousness Reasoning
Routine sensor integration using established biomedical engineering techniques, representing a predictable technological enhancement
Source Patent Element
Modular pump housing design allowing cartridge replacement
PTD Variation
Interchangeable cartridges for different medication types across therapeutic domains
Obviousness Reasoning
Obvious design modification leveraging existing modular architectural principles in medical device engineering
Source Patent Element
Transcutaneous medication delivery mechanism
PTD Variation
Alternative delivery mechanisms like iontophoresis and electroporation for enhanced medication absorption
Obviousness Reasoning
Known alternative transdermal delivery techniques representing standard engineering design alternatives within the established technological domain
35 U.S.C. § 103 Summary: Based on US Patent 11857757's comprehensive disclosure of microdosing patch pump technologies, the present publication demonstrates that extending such systems to diverse therapeutic applications represents an obvious technological variation to a Person Having Ordinary Skill In The Art. The disclosed innovations constitute prima facie obviousness by systematically applying known medical device engineering principles across multiple medication delivery contexts, where the fundamental technological architecture remains substantially unchanged.

Original Patent Information

Patent NumberUS 11,857,757
TitleSystems and methods for delivering microdoses of medication
Assignee(s)Tandem Diabetes Care Switzerland Sàrl