Advanced Physiological Response Systems

Publication ID: 24-11857758_0002_PTD
Published: November 07, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Advanced Physiological Response Systems,” Published Technical Disclosure No. 24-11857758_0002_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857758_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,758.

Summary of the Inventive Concept

The Advanced Physiological Response Systems leverage the core technology of implantable drug delivery devices to monitor and respond to various physiological reactions, addressing previously unmet needs in environmental pollution, athletic injuries, anxiety disorders, and allergic reactions.

Background and Problem Solved

The original patent focused on drug delivery devices for treating opioid overdoses. However, the limitations of this approach lie in its narrow application scope. The Advanced Physiological Response Systems expand this technology to tackle a broader range of health concerns, providing a more comprehensive solution for monitoring and responding to physiological reactions.

Detailed Description of the Inventive Concept

The Advanced Physiological Response Systems comprise implantable sensors capable of detecting changes in body temperature and other physiological reactions indicative of exposure to toxic substances, injuries, allergic reactions, or anxiety disorders. These sensors trigger the release of a counteracting agent, such as a cooling agent, pain-relieving agent, or calming agent, from an integrated drug delivery device. This real-time response enables prompt treatment and prevention of further damage to the body.

Novelty and Inventive Step

The new claims introduce a novel application of the original patent's technology, shifting the focus from opioid overdoses to a diverse range of health concerns. The inventive step lies in the integration of sensors and drug delivery devices to create a holistic response system, which is not obvious from the original patent.

Alternative Embodiments and Variations

Alternative embodiments may include wearable devices, external sensors, or non-invasive monitoring methods. Variations could involve different types of counteracting agents, tailored to specific physiological reactions or health conditions.

Potential Commercial Applications and Market

The Advanced Physiological Response Systems have vast commercial potential in industries such as environmental monitoring, sports medicine, mental health, and allergy treatment. The market demand for such systems is substantial, driven by the growing need for proactive and personalized healthcare solutions.

CPC Classifications

SectionClassGroup
A A61 A61M5/14276
A A61 A61B5/4839
A A61 A61B5/4845
A A61 A61B5/4848
A A61 A61K9/0024
A A61 A61K9/0097
A A61 A61M5/44
A A61 A61M31/002
A A61 A61M37/0069
A A61 A61B5/01
A A61 A61F2250/0068
A A61 A61K31/485

Field of Art

Medical device technology, specifically implantable drug delivery systems and physiological monitoring devices, encompassing biomedical sensors, drug release mechanisms, and adaptive medical response technologies

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device designer with expertise in implantable sensors, drug delivery systems, and physiological monitoring, possessing knowledge of materials science, biocompatible polymers, and adaptive medical technologies

Obviousness Rationale

A PHOSITA would recognize that the core technological framework of the source patent's implantable drug delivery device can be readily adapted to multiple physiological response scenarios by substituting detection mechanisms, trigger conditions, and drug payloads. The fundamental design principles of sensor-triggered drug release remain consistent across different medical applications, making the PTD's variations predictable extensions of the original patent's core technology.

Obvious Combinations & Variations

Source Patent Element
Implantable device with reservoir containing drug and temporary seal
PTD Variation
Expanding drug reservoir to include multiple agent types for different physiological responses
Obviousness Reasoning
Known technique of modifying drug payload is a predictable design variation within medical device engineering, representing a simple substitution of known elements
Source Patent Element
Method of detecting physiological reaction to trigger drug release
PTD Variation
Extending detection mechanisms to include temperature, heart rate, and other physiological indicators
Obviousness Reasoning
Expanding sensor capabilities represents an obvious improvement using known monitoring techniques in biomedical engineering
Source Patent Element
Temporary seal formed of biocompatible cross-linked polymer
PTD Variation
Adapting polymer composition to support different environmental and physiological conditions
Obviousness Reasoning
Material science allows predictable modifications of polymer structures to suit specific medical device requirements
Source Patent Element
Drug delivery for specific physiological condition (opioid overdose)
PTD Variation
Applying similar delivery mechanism to athletic injuries, anxiety, allergic reactions
Obviousness Reasoning
Transferring a known medical device concept across related physiological response domains represents an obvious technological adaptation
Source Patent Element
Single-use implantable drug delivery device
PTD Variation
Developing multi-purpose sensor-integrated response systems
Obviousness Reasoning
Expanding single-purpose device to multi-functional system is a predictable evolution in medical device design, representing combinable known elements
35 U.S.C. § 103 Summary: Based on US Patent 11857758, the present publication demonstrates that a person having ordinary skill in the art would find the disclosed physiological response systems obvious, as they represent predictable variations employing known medical device design principles, sensor technologies, and drug delivery mechanisms, thereby anticipating and rendering obvious future claims with substantially similar technological approaches.

Original Patent Information

Patent NumberUS 11,857,758
TitleDrug delivery device and method
Assignee(s)Purdue Research Foundation