Peripheral Nerve Stimulation for Diverse Therapeutic Applications

Publication ID: 24-11857778_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Peripheral Nerve Stimulation for Diverse Therapeutic Applications,” Published Technical Disclosure No. 24-11857778_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857778_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,778.

Summary of the Inventive Concept

This inventive concept expands the core technology of peripheral nerve stimulation to address various unmet medical needs in new industries, including chronic pain management, cognitive function enhancement, anxiety disorder treatment, sleep quality improvement, and motor function restoration.

Background and Problem Solved

The original patent focused on treating inflammatory bowel disease through peripheral nerve stimulation. However, this technology has broader potential applications. The new inventive concept addresses the limitations of the original patent by exploring alternative uses for peripheral nerve stimulation, thereby providing new therapeutic solutions for diverse medical conditions.

Detailed Description of the Inventive Concept

The inventive concept involves applying the core technology of peripheral nerve stimulation to new therapeutic areas. This is achieved by modulating autonomic tone, parasympathetic tone, or sympathetic tone through transcutaneous stimulation of specific peripheral nerves. For instance, stimulating the residual limb can treat chronic pain in amputees, while stimulating the vagus nerve can enhance cognitive function in individuals with traumatic brain injury. Similarly, stimulating the saphenous nerve can treat anxiety disorders in individuals with autism spectrum disorder, stimulating the median nerve can improve sleep quality in individuals with insomnia, and stimulating the tibial nerve can enhance motor function in individuals with spinal cord injury.

Novelty and Inventive Step

The new claims introduce novel applications of peripheral nerve stimulation, expanding its therapeutic scope beyond inflammatory bowel disease. The inventive step lies in identifying specific peripheral nerves and stimulation parameters that can effectively address diverse medical conditions, thereby providing new and non-obvious solutions.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include varying the type of peripheral nerve stimulated, the stimulation parameters, or the specific medical condition being targeted. Additionally, the inventive concept could be adapted for use in other industries, such as sports medicine or cosmetic treatments, to enhance performance or appearance.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including pain management, neurology, psychiatry, and rehabilitation. The target markets include pharmaceutical companies, medical device manufacturers, and healthcare providers seeking innovative solutions for unmet medical needs.

Original Patent Information

Patent NumberUS 11,857,778
TitleSystems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
Assignee(s)Cala Health, Inc.