Synergistic Systems for Treating Inflammatory Bowel Disease through Peripheral Nerve Stimulation and AI-Powered Personalized Medicine

Publication ID: 24-11857778_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Systems for Treating Inflammatory Bowel Disease through Peripheral Nerve Stimulation and AI-Powered Personalized Medicine,” Published Technical Disclosure No. 24-11857778_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857778_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,778.

Summary of the Inventive Concept

This inventive concept integrates peripheral nerve stimulation with AI, IoT, and blockchain technologies to create a personalized treatment system for inflammatory bowel disease, offering improved treatment outcomes and enhanced patient care.

Background and Problem Solved

The original patent disclosed a method for treating inflammatory bowel disease through peripheral nerve stimulation. However, it lacked the capability to provide personalized treatment recommendations, secure patient data management, and real-time monitoring of treatment response. The new inventive concept addresses these limitations by combining peripheral nerve stimulation with AI-powered diagnostic capabilities, IoT-enabled sensors, and blockchain-based patient data management.

Detailed Description of the Inventive Concept

The synergistic system consists of a peripheral nerve stimulation module, an AI-powered diagnostic module, and a blockchain-based patient data management system. The AI-powered diagnostic module analyzes the patient's medical history and provides personalized treatment recommendations. The peripheral nerve stimulation module delivers targeted electrical stimulation to the patient's peripheral nerves based on the AI-recommended treatment plan. The blockchain-based patient data management system securely stores and updates the patient's treatment records, ensuring data integrity and confidentiality. The system also incorporates IoT-enabled sensors to monitor the patient's vital signs and treatment response, transmitting the data to a cloud-based server for analysis and feedback.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious in its combination of peripheral nerve stimulation with AI-powered diagnostics, IoT-enabled sensors, and blockchain-based patient data management. The integration of these distinct technologies enables personalized treatment recommendations, real-time monitoring, and secure data management, which are not possible with the original patent's method.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different AI algorithms, various IoT sensor configurations, or alternative blockchain-based data management systems. Additionally, the system could be adapted for treating other inflammatory diseases or expanded to include additional diagnostic modalities.

Potential Commercial Applications and Market

The synergistic system has significant commercial potential in the healthcare industry, particularly in the treatment of inflammatory bowel disease. The system's ability to provide personalized treatment recommendations, real-time monitoring, and secure data management addresses a significant unmet need in the market. The target industries include pharmaceutical companies, medical device manufacturers, and healthcare providers.

Field of Art

Biomedical engineering, specifically neuromodulation and medical treatment systems for inflammatory gastrointestinal diseases, with expertise in electrical nerve stimulation, medical device design, and digital health technologies

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device researcher with advanced degrees, knowledge of peripheral nerve stimulation techniques, familiarity with digital health technologies, and understanding of treatment protocols for inflammatory bowel diseases

Obviousness Rationale

A PHOSITA would recognize that integrating digital technologies with existing peripheral nerve stimulation methods represents a predictable extension of the source patent's core technique. The addition of AI, IoT, and blockchain technologies to the fundamental nerve stimulation approach provides a logical progression of treatment monitoring and personalization. These technological augmentations would be considered routine optimization and enhancement of the original nerve stimulation method for inflammatory bowel disease treatment.

Obvious Combinations & Variations

Source Patent Element
Transcutaneous peripheral nerve stimulation for treating inflammatory gastrointestinal diseases
PTD Variation
Adding AI-powered diagnostic module to customize nerve stimulation parameters
Obviousness Reasoning
Adapting stimulation parameters using machine learning is a predictable application of known optimization techniques in medical device design
Source Patent Element
Electrical nerve stimulation with specific nerve fiber targeting
PTD Variation
Incorporating IoT sensors to monitor patient response and adjust stimulation in real-time
Obviousness Reasoning
Real-time physiological monitoring is a standard approach in medical device development for personalizing treatment protocols
Source Patent Element
Method of delivering electrical stimulation to peripheral nerves
PTD Variation
Implementing blockchain-based patient data management for secure treatment tracking
Obviousness Reasoning
Secure digital record-keeping is a known technique for managing medical treatment data across healthcare technologies
Source Patent Element
Nerve stimulation for inflammatory gastrointestinal disease treatment
PTD Variation
Creating a wearable device with wireless communication for treatment data transmission
Obviousness Reasoning
Miniaturization and wireless connectivity are predictable technological improvements in medical device design
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857778 for peripheral nerve stimulation in inflammatory bowel disease treatment, the present publication demonstrates that integrating digital health technologies such as AI diagnostics, IoT monitoring, and blockchain data management would be obvious to a person having ordinary skill in the art. The disclosed variations represent routine technological enhancements that would be predictable to a skilled practitioner, thereby rendering potential derivative claims obvious and unpatentable.

Original Patent Information

Patent NumberUS 11,857,778
TitleSystems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
Assignee(s)Cala Health, Inc.